Hotels NearUptown
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Featured Uptown Hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Beautiful Hotel! Comfortable rooms and friendly staff.
Reviewed on Nov 28, 2025

Hyatt Regency St. Louis at The Arch
Awesome!!
Reviewed on Dec 2, 2025

Drury Plaza Hotel St. Louis at the Arch
Clean rooms friendly staff and amenities
Reviewed on Dec 3, 2025

Forest Park Hotel by MDR
My entire room was clean, the staff are nice, the amenities were efficient…
Reviewed on Nov 28, 2025

Clayton Plaza Hotel & Extended Stay
What a wonderful hotel. Everything was spotless, towels plentiful, breakfast was superb and every employee we encountered were genuinely friendly and polite. We stayed an additional night because it was so comfortable. We will definitely be staying again.
Reviewed on Nov 29, 2025

21C Museum Hotel St Louis
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.
Reviewed on Dec 2, 2025

Drury Inn & Suites St. Louis Union Station
Clean room. Wonderful staff. And great freebies!!!
Reviewed on Nov 30, 2025

Home2 Suites by Hilton St. Louis Downtown
Great customer service horrible location
Reviewed on Nov 29, 2025

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
clean room, great staff, amenities where great just missing a hot tub
Reviewed on Nov 30, 2025

Live by Loews - St.Louis
Next to the Baseball stadium
Reviewed on Dec 1, 2025

St. Louis Union Station Hotel, Curio Collection by Hilton
Room was enormous. Beautiful hotel. So much to do without leaving
Reviewed on Nov 28, 2025

Embassy Suites by Hilton St. Louis Downtown
Great hospitality
Reviewed on Nov 30, 2025
Hotels in Uptown
Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $89
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Uptown Neighborhoods
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
- Hotels near Scott Air Force Base (10.46 mi)
Cities near Uptown
- O'Fallon Hotels (6.7 mi)
- Fairview Heights Hotels (5.15 mi)
- Edwardsville Hotels (9.2 mi)
- Collinsville Hotels (0.35 mi)
- Alton Hotels (18.64 mi)
- Belleville Hotels (10.13 mi)
- Richmond Heights Hotels (17.92 mi)
- Brentwood Hotels (19.63 mi)
- East St. Louis Hotels (9.39 mi)
- Webster Groves Hotels (20.42 mi)
- Ozarks Hotels (171.91 mi)
- Southern Illinois Hotels (65.36 mi)
- Granite City Hotels (8.84 mi)
- Florissant Hotels (19.77 mi)
- Troy Hotels (5.8 mi)
- Columbia Hotels (19.13 mi)
- Caseyville Hotels (2.45 mi)
- Jennings Hotels (15.24 mi)
- Overland Hotels (20.53 mi)
- Shiloh Hotels (8.84 mi)
