Search for Cheap Deals onHotels in Southern Illinois
Choose from 1164 Southern Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
"This was our first time to stay in a Drury Inn. As we arrived in the evening from our long drive, it was a nice surprise that there was a complementary dinner provided. It was very good! The breakfast the next morning was also very good. The woman keeping things stocked at breakfast was very dedicated ..."
Reviewed on Jul 26, 2026
Ramada by Wyndham Effingham
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis O'Fallon, IL
"Great hotel and staff"
Reviewed on Jul 26, 2026
Best Western St. Louis Fairview Heights
"The room was clean. There was no trash can, we went down and asked for more towels and a trash can. We were given the towels and was told they'd bring up the trash can but it was delivered. Breakfast was hot"
Reviewed on Jul 26, 2026
Country Inn & Suites by Radisson, Fairview Heights, IL
"Room was clean and comfortable. Clean bathroom"
Reviewed on Jul 26, 2026
Super 8 by Wyndham O'Fallon
"I would not recommend for anyone to stay here. The hotel stunk of cigarette smoke. Drug deals being done right out front. Furniture was broken. Just HORRIBLE!! Staff was very unfriendly RUDE!"
Reviewed on Jul 26, 2026
Comfort Suites Fairview Heights - St. Louis
"Great place! Easy access to local shopping and restaurants."
Reviewed on Jul 26, 2026
Holiday Inn Express Metropolis by IHG
"The room was very clean and comfortable, breakfast was amazing."
Reviewed on Jul 26, 2026
The Principal Hotel
"The hotel was very cute and clean. The location was lovely. Room was very spacious. We loved the theming!"
Reviewed on Jul 25, 2026
Motel 6 Caseyville, IL - Caseyville Il
"The building smelt like animal urine and the AC barely kept the room cool. We also paid for a room with a microwave and refrigerator and the refrigerator wasn’t cold. The staff were very friendly though"
Reviewed on Jul 26, 2026
Drury Inn & Suites Marion
Find cheap hotels in Southern Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,164 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Illinois for as low as $62.
How many hotels are there in Southern Illinois?
With over 1,164 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.
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Finding a cheap car rental deal in Southern Illinois is as easy as scoring cheap hotels in Southern Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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- Lambert-St. Louis Intl. Airport Hotels
- Spirit of St. Louis Airport Hotels
- Cape Girardeau Municipal Airport Hotels
- Decatur Airport Hotels
- Evansville Regional Airport Hotels
- Veterans of Southern Illinois Airport Hotels
- Barkley Regional Airport Hotels
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- Cairo Regional Airport Hotels
- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Garden of the Gods Recreation Area
- Hotels near Lake of Egypt
- Hotels near World Wide Technology Raceway
- Hotels near Giant City State Park
- Hotels near O'Fallon Family Sports Park
- Hotels near Rend Lake
- Hotels near Carlyle Lake
- Hotels near Harrah's Metropolis
- Hotels near Scott Air Force Base
- Hotels near Cahokia Mounds State Historic Site
- Hotels near McKendree University
- Hotels near Lake Sara
- Hotels near DuQuoin State Fairgrounds
- Hotels near Gateway Conference Center
- Hotels near Effingham Performance Center
- Hotels near Superman Statue
- Hotels near Cave in Rock State Park
- Hotels near St. Claire Square Mall
- Hotels with Free Parking in Southern Illinois
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- Resorts & Hotels with Spas in Southern Illinois
- Hotel Wedding Venues in Southern Illinois
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- St. Charles Hotels
- Evansville Hotels
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- Maryland Heights Hotels
- Terre Haute Hotels
- Fenton Hotels
- Cape Girardeau Hotels
- O'Fallon Hotels
- Marion Hotels
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- Mount Vernon Hotels
- Carbondale Hotels
- Decatur Hotels
- Collinsville Hotels
- Gilbertsville Hotels
- Fairview Heights Hotels
- Ozarks Hotels
- Eureka Hotels
- Sikeston Hotels
