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Drury Inn & Suites St. Louis Fairview Heights
"Breakfast normally has one of the best offerings of a hotel breakfast, but this trip the hot breakfast had mostly empty bowls showing signs of lack of attention by staff. After fresh food was delivered, it looked like a pack of wild animals attacking prey. Would atay again but have back up breakfast ..."
Reviewed on May 20, 2026
Drury Plaza Hotel Mt. Vernon
"Wonderful stay! Great hotel and convenient location off the highway. We loved the evening meal and happy hour."
Reviewed on May 19, 2026
Walker's Bluff Casino Resort
"Wonderful experience! Second time staying at this property. Top-notch"
Reviewed on May 18, 2026
Super 8 by Wyndham O'Fallon
"I stayed 2 nights the second night Iwecwerevaw9ken by bed bugs. We packed and left. When I asked the front desk if they refunded she said no because we already stayed there and didn't say nothing prior. The minute we saw the bed bugs we were out. All she said was sorry. Don't stay there bed bugs ..."
Reviewed on May 20, 2026
Baymont by Wyndham Effingham
"Clean room, excellent staff"
Reviewed on May 21, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
"It was awesome the staff was nice and the room was excellent"
Reviewed on May 20, 2026
Quality Inn O'Fallon IL - St. Louis
"Breakfast was very lacking."
Reviewed on May 20, 2026
Holiday Inn Express & Suites Mount Vernon by IHG
"The day was OK, but the AC needs to be improved vacuumed and the windows cleaned and a little bit in the bathroom. Several hairs on the floor the bed was comfortable in ice. Water in the lobby was great. I’ve stayed here a couple times and never had any problems until now. That’s all minor."
Reviewed on May 17, 2026
Ramada by Wyndham Effingham
"Was very mediocre at best"
Reviewed on May 20, 2026
Drury Inn & Suites Marion
The Principal Hotel
"Everything was very nice"
Reviewed on May 20, 2026
Quality Inn & Suites Metropolis I-24
"I called and was told no reservation at Wuakity Inn. And was told my reservation is at Super 8 Super 8 also had no reservation but checked me in BIG MISTAKE cigarette smoke infiltrated my room. Really bad stay for that reason. The vestibule smelled like weed. Poorly attended Took 3 trips up and down ..."
Reviewed on May 20, 2026
Find cheap hotels in Southern Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,140 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $65. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Southern Illinois?
With over 1,140 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $65.
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- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Lake of Egypt
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