Search for Cheap Deals onHotels in Southern Illinois
Choose from 1164 Southern Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
"Nice"
Reviewed on Jul 25, 2026
Drury Inn & Suites Marion
"Wonderful staff! My go to hotel when we travel down south."
Reviewed on Jul 24, 2026
Drury Plaza Hotel Mt. Vernon
Best Western St. Louis Fairview Heights
"Clean room but ankle deep water when showering."
Reviewed on Jul 25, 2026
Country Inn & Suites by Radisson, Fairview Heights, IL
"The staff was helpful and she was really nice. It was only two problems it had an odor and the stopper didn’t work, but besides that the stay was awesome. The location was the BEST!! You have everything and anything you want and need."
Reviewed on Jul 24, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
"The hotel was clean and conveniently located with lots of food and drink options close. Room was clean and beds comfortable. Breakfast and evening snacks/drinks were great and many options. Great experience and will come back again."
Reviewed on Jul 25, 2026
Super 8 by Wyndham O'Fallon
"Desk staff were professional but abrupt. Room amenities were minimal...not even a single cup. Shower head was tiny...took effort to wash my hair and body. Pillows were small, but firm. Bed was comfortable. Two dogs in the room next to me barked early and often."
Reviewed on Jul 25, 2026
Comfort Suites Fairview Heights - St. Louis
"Nice room good size location is good"
Reviewed on Jul 25, 2026
The Principal Hotel
"The hotel was very cute and clean. The location was lovely. Room was very spacious. We loved the theming!"
Reviewed on Jul 25, 2026
Motel 6 Caseyville, IL - Caseyville Il
"The policy listed said 18 year olds or older could check in. When my son arrived at 3a.m. the man said he had to be 21 yes old. He had to bring up hotel.com and show him what it said before he allowed him to stay in the pre paid room."
Reviewed on Jul 25, 2026
Comfort Suites Mount Vernon
DoubleTree by Hilton Mt. Vernon
"Very friendly front desk and restaurant staff. Easily accessible ice maker and water bottle refill station next to elevator in main lobby. Large buffet style breakfast with several options and coffee to go all included. Cleanliness of the room was not the best. Food and garbage from previous guests ..."
Reviewed on Jul 22, 2026
Find cheap hotels in Southern Illinois
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,164 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Southern Illinois?
With over 1,164 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.
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- Hotel Brand
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- Lambert-St. Louis Intl. Airport Hotels
- Spirit of St. Louis Airport Hotels
- Cape Girardeau Municipal Airport Hotels
- Decatur Airport Hotels
- Evansville Regional Airport Hotels
- Veterans of Southern Illinois Airport Hotels
- Barkley Regional Airport Hotels
- MidAmerica-St. Louis Airport Hotels
- Cairo Regional Airport Hotels
- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Garden of the Gods Recreation Area
- Hotels near Lake of Egypt
- Hotels near World Wide Technology Raceway
- Hotels near Giant City State Park
- Hotels near O'Fallon Family Sports Park
- Hotels near Rend Lake
- Hotels near Carlyle Lake
- Hotels near Harrah's Metropolis
- Hotels near Scott Air Force Base
- Hotels near Cahokia Mounds State Historic Site
- Hotels near McKendree University
- Hotels near Lake Sara
- Hotels near DuQuoin State Fairgrounds
- Hotels near Gateway Conference Center
- Hotels near Effingham Performance Center
- Hotels near Superman Statue
- Hotels near Cave in Rock State Park
- Hotels near St. Claire Square Mall
- Hotels with Free Parking in Southern Illinois
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- St. Charles Hotels
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- Maryland Heights Hotels
- Terre Haute Hotels
- Fenton Hotels
- Cape Girardeau Hotels
- O'Fallon Hotels
- Marion Hotels
- Effingham Hotels
- Mount Vernon Hotels
- Carbondale Hotels
- Decatur Hotels
- Collinsville Hotels
- Gilbertsville Hotels
- Fairview Heights Hotels
- Ozarks Hotels
- Eureka Hotels
- Sikeston Hotels
