Search for Cheap Deals onHotels in Southern Illinois
Choose from 1194 Southern Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
"The hotel and room were clean; breakfast buffet was good. Staff were friendly."
Reviewed on Sep 10, 2026
Drury Plaza Hotel Mt. Vernon
"Clean. Free parking. Happy hour. Great breakfast."
Reviewed on Sep 10, 2026
Baymont by Wyndham Effingham
"Recently remodeled/maybe some still going on? Absolutely wonderful property, easily handicap accessible. Staff was friendly and helpful. Breakfast was above and beyond expectations. We would definitely stay again but would hope for a softer bed! Our only complaint!"
Reviewed on Sep 10, 2026
Quality Inn O'Fallon - St. Louis - Shiloh
"We stayed one night, because it was right off the interstate. On our way to our final destination. Rooms were clean property was clean. There’s a lot of places to grab a bite to eat and Walmart is across the street. If you need other stuff. Felt very safe."
Reviewed on Sep 11, 2026
Drury Inn & Suites St. Louis O'Fallon, IL
"Awesome friendly workers. Cleanest hotel in the world."
Reviewed on Sep 10, 2026
Super 8 by Wyndham O'Fallon
Comfort Inn Edwardsville - St. Louis
Quality Inn & Suites Metropolis I-24
Country Inn & Suites by Radisson, Effingham, IL
"I accidentally booked the wrong date on a non refundable stay and noticed immediately. Contacted Expedia by chat and they were totally useless to assist in changing the date. Called the hotel directly and they changed the reservation immediately. Great customer service from the hotel, not great from ..."
Reviewed on Sep 10, 2026
Comfort Suites Fairview Heights - St. Louis
"overall ok"
Reviewed on Sep 11, 2026
Comfort Suites Mount Vernon
"The staff was very attentive to my needs when I needed assistance with the air conditioning and one evening there was a dog barking that was very bothersome that was taken care of right away. The room was clean and well kept. It’s just dated. Everyone was super friendly."
Reviewed on Sep 9, 2026
Best Western Delta Inn
"We had a hole in the door of our room"
Reviewed on Sep 5, 2026
Find cheap hotels in Southern Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,194 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $59. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Illinois for as low as $59.
How many hotels are there in Southern Illinois?
With over 1,194 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.
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Finding a cheap car rental deal in Southern Illinois is as easy as scoring cheap hotels in Southern Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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- Lambert-St. Louis Intl. Airport Hotels
- Spirit of St. Louis Airport Hotels
- Cape Girardeau Municipal Airport Hotels
- Decatur Airport Hotels
- Evansville Regional Airport Hotels
- Veterans of Southern Illinois Airport Hotels
- Barkley Regional Airport Hotels
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- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Garden of the Gods Recreation Area
- Hotels near World Wide Technology Raceway
- Hotels near Lake of Egypt
- Hotels near Rend Lake
- Hotels near Cahokia Mounds State Historic Site
- Hotels near Giant City State Park
- Hotels near O'Fallon Family Sports Park
- Hotels near Harrah's Metropolis
- Hotels near DuQuoin State Fairgrounds
- Hotels near McKendree University
- Hotels near Scott Air Force Base
- Hotels near Carlyle Lake
- Hotels near Lake Sara
- Hotels near Cave in Rock State Park
- Hotels near Tunnel Hill State Trail
- Hotels near Superman Statue
- Hotels near St. Clair Bowl
- Hotels near Effingham Performance Center
- Hotels with Free Parking in Southern Illinois
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- St. Charles Hotels
- Evansville Hotels
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- Maryland Heights Hotels
- Effingham Hotels
- Carbondale Hotels
- Cape Girardeau Hotels
- Marion Hotels
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- O'Fallon Hotels
- Decatur Hotels
- Mount Vernon Hotels
- Alton Hotels
- Collinsville Hotels
- Ozarks Hotels
- Fenton Hotels
- Grafton Hotels
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