Hotels NearMedical Center District
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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Room was very neatly clean. Gym is good although one of treadmill does not work. Breakfast is good. Staff: very friendly.
Reviewed on Dec 2, 2025

San Antonio Marriott Northwest Medical Center
It was a beautiful hotel and staff was courtious. Rooms were clean and roomy. Breakfast was great.!
Reviewed on Nov 28, 2025

Courtyard by Marriott Medical Center San Antonio
Room was clean, staff was very friendly!!
Reviewed on Nov 19, 2025

Hotel Valencia Riverwalk
Great hotel
Reviewed on Dec 3, 2025

Riverwalk Plaza
The beds werent
Reviewed on Dec 3, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Great atmosphere and space. highly recommend.
Reviewed on Dec 2, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Loved it, clean nice just a walk away to riverwalk
Reviewed on Dec 2, 2025

Drury Plaza Hotel San Antonio Riverwalk
clean, convenient, excellent staff
Reviewed on Nov 28, 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
The rooms were clean but old as we had loose door knobs. Eating options on sire are limited and the only restaurant available closes at 8pm. We order margaritas that we were not impressed with at all( made from crushed ice and it was so over diluted not worthy the 38 bucks plus tip we paid for two ...
Reviewed on Dec 2, 2025

Omni La Mansion del Rio
Great location great service
Reviewed on Dec 3, 2025

Crockett Hotel
Its an older typical hotel. The location is wonderful! steps outside the alamo Plaza and a few steps to a indoor mall.
Reviewed on Dec 2, 2025

La Quinta Inn & Suites by Wyndham San Antonio Downtown
The staff was nice and helpful. Unfortunately the room was not spotless
Reviewed on Dec 1, 2025
Hotels in Medical Center District
San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $94
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.
Medical Center District Neighborhoods
Top Attractions in Medical Center District
- Hotels near USAA Corporate Office Headquarters (2.34 mi)
- Hotels near South Texas Medical Center (0.35 mi)
- Hotels near University of Texas Health and Science Center at San Antonio (0.21 mi)
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center (0.86 mi)
- Hotels near Oak Hills Country Club (0.83 mi)
- Hotels near The San Antonio Art Institute (1.96 mi)
- Hotels near River Walk (7.85 mi)
- Hotels near Lackland Air Force Base (8.68 mi)
- Hotels near Six Flags Fiesta Texas (6.74 mi)
- Hotels near Henry B. González Convention Center (7.98 mi)
- Hotels near Alamo (7.78 mi)
- Hotels near Alamodome (8.61 mi)
- Hotels near San Antonio River (7.6 mi)
- Hotels near Frost Bank Center (9.97 mi)
- Hotels near San Antonio Zoo and Aquarium (6.87 mi)
- Hotels near The Shops of La Cantera (6.41 mi)
Cities near Medical Center District
- New Braunfels Hotels (30.36 mi)
- Boerne Hotels (21.98 mi)
- Hill Country Hotels (68.54 mi)
- Schertz Hotels (18.72 mi)
- Castroville Hotels (20.91 mi)
- Helotes Hotels (8.4 mi)
- Spring Branch Hotels (25.15 mi)
- Bulverde Hotels (18.01 mi)
- Selma Hotels (17.15 mi)
- Converse Hotels (15.69 mi)
- Universal City Hotels (17.41 mi)
- Cibolo Hotels (21.05 mi)
- Elmendorf Hotels (22.67 mi)
- Pipe Creek Hotels (26.19 mi)
- Lytle Hotels (23.08 mi)
- West Texas Hotels (215.71 mi)
- South Texas Hotels (94.36 mi)
- Von Ormy Hotels (15.74 mi)
- North San Antonio - SAT Hotels (8.06 mi)
- Northwest San Antonio Hotels (7.2 mi)
