Search for Cheap Deals on4 Star Hotels in Medical Center District
Photo by Linda Cronan
Check Last Minute Medical Center District Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured 4 Star Medical Center District Hotels

Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy 5 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff ...
Save an average of 15% on thousands of hotels when you're signed in

Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...

Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy 4 outdoor pools, a full-service spa, and 6 restaurants. Our guests praise the helpful staff and the ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and breakfast (surcharge). Our guests praise the helpful staff and ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the restaurant ...

Fully refundable
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Popular attractions Alamo and River Walk are located ...
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular Medical Center District Hotels
- La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
- San Antonio Marriott Northwest Medical Center
- Courtyard by Marriott Medical Center San Antonio
- Riverwalk Plaza
- La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
- Sonesta ES Suites San Antonio Downtown Alamo Plaza
- Crockett Hotel
- La Cantera Resort & Spa
- The Westin Riverwalk, San Antonio
- Spark By Hilton San Antonio Northwest near Six Flags
Top Attractions in Medical Center District
- Hotels near USAA Corporate Office Headquarters (2.34 mi)
- Hotels near South Texas Medical Center (0.35 mi)
- Hotels near University of Texas Health and Science Center at San Antonio (0.21 mi)
- Hotels near CHRISTUS Santa Rosa Hospital - Medical Center (0.86 mi)
- Hotels near Oak Hills Country Club (0.83 mi)
- Hotels near The San Antonio Art Institute (1.96 mi)
- Hotels near River Walk (7.85 mi)
- Hotels near Six Flags Fiesta Texas (6.74 mi)
- Hotels near Lackland Air Force Base (8.68 mi)
- Hotels near Alamo (7.78 mi)
- Hotels near Henry B. González Convention Center (7.98 mi)
- Hotels near San Antonio Zoo and Aquarium (6.87 mi)
- Hotels near Alamodome (8.61 mi)
- Hotels near San Antonio River (7.6 mi)
- Hotels near The Shops of La Cantera (6.41 mi)
- Hotels near The Rim Shopping Center (7.16 mi)
Nearby Cities
- New Braunfels Hotels (30.36 mi)
- Boerne Hotels (21.98 mi)
- Hill Country Hotels (68.54 mi)
- Schertz Hotels (18.72 mi)
- Gulf Coast Hotels (306.58 mi)
- Spring Branch Hotels (25.15 mi)
- Helotes Hotels (8.4 mi)
- Selma Hotels (17.15 mi)
- Universal City Hotels (17.41 mi)
- Bulverde Hotels (18.01 mi)
- Converse Hotels (15.69 mi)
- Castroville Hotels (20.91 mi)
Recommended cities for you
- Las Vegas Hotels
- New York Hotels
- Orlando Hotels
- Los Angeles Hotels
- Miami Hotels
- San Francisco Hotels
- New Orleans Hotels
- Chicago Hotels
- Fort Lauderdale Hotels
- Boston Hotels
- Honolulu Hotels
- San Diego Hotels
- Washington Hotels
- Toronto Hotels
- Anaheim Hotels
- Atlanta Hotels
- Nashville Hotels
- Seattle Hotels
- Phoenix Hotels
- Myrtle Beach Hotels
Car Rentals Near Medical Center District
- Car rentals in New Braunfels
- Car rentals in Boerne
- Car rentals in Hill Country
- Car rentals in Schertz
- Car rentals in Gulf Coast
- Car rentals in Spring Branch
- Car rentals in Helotes
- Car rentals in Selma
- Car rentals in Universal City
- Car rentals in Bulverde
- Car rentals in Converse
- Car rentals in Castroville
- Car rentals in Cibolo
- Car rentals in Elmendorf
- Car rentals in South Texas
- Car rentals in Pipe Creek