Hotels Near
Medical Center District

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Check Last Minute Medical Center District Hotel Deals

Tonight May 30 - May 31This weekend May 30 - Jun 1

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,543 reviews)
"Nice big hotel! Rooms were and hot breakfast was great!"

Reviewed on May 26, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,007 reviews)
"Excellent"

Reviewed on May 26, 2025

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,242 reviews)
"Overall our experience was great. Staff was courteous and professional. Exceptional service."

Reviewed on May 28, 2025

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,005 reviews)
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Reviewed on May 26, 2025

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
8/10 Very Good! (5,262 reviews)
"Everything g was good, except there was no tv remote and the staff couldn’t locate one during our stay."

Reviewed on May 28, 2025

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (3,543 reviews)
"Its location is very good, it is just 10 mins walk from Riverwalk. It has stunning city view. Breakfast is included which gives advantage. Pool opens at 10:00 AM which is kind of late as checkout time is 11:00 AM so people cannot use pool in the morning. Another issue is we found hair on the bed ..."

Reviewed on May 29, 2025

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Sonesta ES Suites San Antonio Downtown Alamo Plaza
Sonesta ES Suites San Antonio Downtown Alamo Plaza
3 out of 5
425 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,544 reviews)
"I loved how family friendly."

Reviewed on May 26, 2025

Sonesta ES Suites San Antonio Downtown Alamo Plaza
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,406 reviews)
"Thanks"

Reviewed on May 27, 2025

Drury Plaza Hotel San Antonio Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.8/10 Excellent! (2,371 reviews)
"I enjoyed my stay overall. The Crockett was just about what I expected. My room was cozier than I anticipated—perhaps a little too dim for my taste—but it was still comfortable and relatively quiet, which I appreciated. The only issue was that the room doors didn’t close quietly. Whenever a new guest ..."

Reviewed on May 27, 2025

Crockett Hotel
La Cantera Resort & Spa
La Cantera Resort & Spa
4 out of 5
16641 La Cantera Pkwy, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy 5 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff ...
8.8/10 Excellent! (1,020 reviews)
Beautiful resort
"La Cantera is a beautiful resort with everything you need."

Reviewed on May 26, 2025

La Cantera Resort & Spa
The Westin Riverwalk, San Antonio
The Westin Riverwalk, San Antonio
4 out of 5
420 W Market St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
8.6/10 Excellent! (1,217 reviews)
"Location is perfect, friendly recreation, house keeping need improvement"

Reviewed on May 28, 2025

The Westin Riverwalk, San Antonio
Spark By Hilton San Antonio Northwest near Six Flags
Spark By Hilton San Antonio Northwest near Six Flags
3 out of 5
6755 North Loop 1604 West, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the clean rooms in our reviews. Popular attractions ...
8/10 Very Good! (1,152 reviews)
"If you’re going to Fiesta Texas, this is your place to stay. Super close and food places with in walking distance."

Reviewed on May 28, 2025

Spark By Hilton San Antonio Northwest near Six Flags
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $84
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.