Hotels Near
Medical Center District

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Featured Medical Center District Hotels

Flex Studios
Flex Studios
2.5 out of 5
9542 I-10, San Antonio, TX, 78230
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Antonio. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Six Flags Fiesta Texas and USAA Corporate Office Headquarters ...
2.6/5 (117 reviews)
"My stay waz wonderful. It was quiet. Spacious room very comfortable. I'm definitely going again"

Reviewed on Sep 28, 2022

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX, 78229
Fully refundableReserve now, pay when you stay
Stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
4.2/5 Very Good! (1,856 reviews)
"The first room I received the sofa bed came apart. The second room did the same thing along with TV remotes that could not control the TVs right down to not being able to turn the volume down."

Reviewed on Sep 28, 2022

Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX, 78229
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean ...
4.2/5 Excellent! (1,033 reviews)
"The hotel was very clean and the staff were extra helpful and friendly. I’ll definitely stay there again."

Reviewed on Oct 3, 2022

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX, 78230
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
3.4/5 Good! (1,054 reviews)
"Staff was very accommodating! We had a very late check in and they made it easy to get the hotel room after a long drive. Room also smelled very clean and fresh and bed was comfortable and clean."

Reviewed on Sep 6, 2022

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 out of 5
7203 Wurzbach Road, San Antonio, TX, 78240
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Wonderland of the Americas Mall and USAA Corporate ...
4.4/5 Wonderful! (161 reviews)
"If you want a nice workout gym, this is the place. Clean all around facility, and for me, was the fact it is 2 blocks from the hospital as i had surgery the next morning."

Reviewed on Sep 29, 2022

Studio 6 San Antonio, Tx - Northwest Medical Center
Studio 6 San Antonio, Tx - Northwest Medical Center
2 out of 5
9400 Wurzbach Road, San Antonio, TX, 78240
Fully refundableReserve now, pay when you stay
Stay at this motel in San Antonio. Enjoy free WiFi, a 24-hour front desk, and laundry facilities. Popular attractions Six Flags Fiesta Texas and USAA Corporate ...
2.5/5 (2 reviews)

Reviewed on Sep 5, 2022

Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX, 78205
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the bar and the helpful staff in our ...
3.9/5 Good! (2,321 reviews)
"It was nice and clean. The front desk and housekeeping staff were second to none. Would definitely stay here again."

Reviewed on Oct 5, 2022

Hampton Inn San Antonio-Downtown (River Walk)
Hampton Inn San Antonio-Downtown (River Walk)
2.5 out of 5
414 Bowie St, San Antonio, TX, 78205
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff ...
4/5 Very Good! (1,199 reviews)
"Really clean hotel, comfortable. Just wish the area around was safer/nicer"

Reviewed on Oct 3, 2022

Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX, 78205
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa aparthotel in San Antonio. Enjoy a full-service spa, a rooftop terrace, and breakfast. Our guests praise the helpful staff and the clean ...
4.4/5 Wonderful! (2,729 reviews)
"This hotel rocks!! It has great amenities and sits right on the riverwalk!"

Reviewed on Sep 25, 2022

La Quinta Inn & Suites by Wyndham San Antonio Downtown
La Quinta Inn & Suites by Wyndham San Antonio Downtown
2.5 out of 5
100 W. Cesar Chavez Blvd, San Antonio, TX, 78204
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
4.2/5 Very Good! (1,989 reviews)
"It was nice but I had no internet connection, needs a light in bedroom near mirror, and needs better service- I put out my dirty towels and I had to call front desk to get clean ones, I asked for coffee and I forgot about cups, I had to rinse and use of the same cup. I will pick another Hotel next ..."

Reviewed on Oct 3, 2022

Omni La Mansion del Rio
Omni La Mansion del Rio
4 out of 5
112 College St, San Antonio, TX, 78205
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
4.5/5 Wonderful! (1,643 reviews)
"Our room was nice and quiet and the beds were very comfortable. We did wake up to hearing the A/C vibrating which we had to turn off the fan."

Reviewed on Oct 5, 2022

Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX, 78205
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
4.6/5 Wonderful! (2,137 reviews)
Close to perfect
"The Drury was an easy to get to, comfortable and spacious place to stay. The room was large, had a separated bedroom (that added to how quiet it was), living area and deck overlooking San Fernando square, a garden and the Riverwalk. It was a bit of a maze to find the room as we had to take two elevators ..."

Reviewed on Oct 5, 2022

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $49
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.

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