Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.6/10 Good! (2,531 reviews)
Excellent stay
"Overnight. Room was clean spacious and comfortable. Breakfast was very satisfying."

Reviewed on Mar 25, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8.4/10 Very Good! (2,879 reviews)
Coming back soon
"Great hotel, great price and amazing location"

Reviewed on Mar 25, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean rooms in ...
8.4/10 Very Good! (1,008 reviews)
"Will come back again!"

Reviewed on Mar 25, 2024

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the restaurant and the bar in our reviews. ...
8/10 Very Good! (3,431 reviews)
"Enjoyed the Gavel Restaurant in the building. Good breakfast, nice staff and the bar was open late with excellent live music on Saturday Night. Close to the riverwalk, clean room and just around the corner from San Fernando Cathedral."

Reviewed on Mar 25, 2024

Riverwalk Plaza
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Stay at this 4-star spa hotel in San Antonio. Enjoy an outdoor pool, a full-service spa, and a rooftop terrace. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (2,745 reviews)
"Everything thing was perfect!"

Reviewed on Mar 26, 2024

Hotel Contessa
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (2,745 reviews)
"A fabulous and historic hotel. Sadly, the area in front of the hotel is currently undergoing major reconstruction of the Alamo foreground which made access to the hotel difficult, but this did not take too much away from our overall enjoyment. The room was small but very clean and acceptable. The ..."

Reviewed on Mar 25, 2024

Menger Hotel
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (2,646 reviews)
"Valet communication was not the best."

Reviewed on Mar 24, 2024

Hotel Gibbs Downtown Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool in our ...
7.4/10 Good! (2,540 reviews)
Quick business trip
"Everything was great. Room was clean and staff very friendly. Breakfast was good, loved the variety of food. I was disappointed that the bar/lounge was closed. One of the reasons for choosing this hotel."

Reviewed on Mar 20, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking, and a 24-hour front desk. Our guests praise the pool and the restaurant in our reviews. ...
8.6/10 Excellent! (1,560 reviews)
"Absolutely perfect location to Alamo and Riverwalk and downtown! Great bar and restaurant and coffee shop at hotel and use of facilities at sister hotel next door!"

Reviewed on Mar 25, 2024

Crockett Hotel
Omni La Mansion del Rio
Omni La Mansion del Rio
4 out of 5
112 College St, San Antonio, TX
Stay at this spa hotel in San Antonio. Enjoy 2 restaurants, a full-service spa, and breakfast. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (2,161 reviews)
"This is an ideal hotel for enjoying the Riverwalk. The property is beautiful, staff is extremely friendly and responsive, I can’t think of room for improvement! Valet service was also very quick. We would definitely stay here again!"

Reviewed on Mar 25, 2024

Omni La Mansion del Rio
Hotel Valencia Riverwalk
Hotel Valencia Riverwalk
4 out of 5
150 E Houston St, San Antonio, TX
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the restaurant and the bar in our reviews. ...
9/10 Wonderful! (1,737 reviews)
"I loved that everything is walking distance. And also loved the smell of the hotel we would definitely return there."

Reviewed on Mar 25, 2024

Hotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Airport
Drury Plaza Hotel San Antonio Airport
3 out of 5
95 NE Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
9.2/10 Wonderful! (1,494 reviews)
"We appreciated the complimentary kickback time in the evenings. The staff was very pleasant. Our room was quiet, even being by some major roadways."

Reviewed on Mar 24, 2024

Drury Plaza Hotel San Antonio Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $79
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.