Hotels Near
Medical Center District

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Featured Medical Center District Hotels

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8.4/10 Very Good! (2,544 reviews)
"Very clean and calm"

Reviewed on Sep 30, 2023

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Popular attractions Six Flags Fiesta Texas and USAA ...
8.6/10 Excellent! (1,003 reviews)
"Excellent"

Reviewed on Oct 1, 2023

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (2,844 reviews)
"It was awesome, friendly staff 👍"

Reviewed on Oct 2, 2023

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the property ...
7.4/10 Good! (2,165 reviews)
"Everything was perfect, we walked everywhere we wanted to go, the service was great, everytime I need to approach the counter for something (ex. Extra towels, shampoo, etc) they also assisted in a friendly and courteous smile.. they made us aware of the amenities upon checkin.. they were ..."

Reviewed on Sep 30, 2023

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundable
Stay at this 3-star historic hotel in San Antonio. Enjoy free WiFi, valet parking, and a 24-hour front desk. Our guests praise the restaurant and the bar in ...
8.6/10 Excellent! (1,153 reviews)
"It was such a cool historical hotel. Very pretty inside. Rooms are older but clean and well kept. Super convenient to the Riverwalk and I am so glad I picked the crocket for my 1st stay in San Antonio."

Reviewed on Sep 30, 2023

Crockett Hotel
Crowne Plaza San Antonio Airport, an IHG Hotel
Crowne Plaza San Antonio Airport, an IHG Hotel
3.5 out of 5
1111 NE Loop 410, San Antonio, TX
Fully refundable
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Popular attractions Quarry Golf Club and Alamo Quarry ...
8.2/10 Very Good! (432 reviews)
"The room was very clean and spacious. Would definitely come back to stay. The lady at the front desk very nice also the house keeper that got us the clean comforter and fixed our bed so nice. The bartender was also very nice. The garlic wings I ate were awesome. The place was just awesome place to ..."

Reviewed on Oct 1, 2023

Crowne Plaza San Antonio Airport, an IHG Hotel
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the breakfast and the bar in our reviews. ...
8.8/10 Excellent! (2,398 reviews)
Worth a visit.
"Wonderful quaint, clean, comfortable, quiet, convenient location. Only issue was the in room coffee maker did not work but we managed. Would stay there again."

Reviewed on Sep 29, 2023

Menger Hotel
Hampton Inn San Antonio-Downtown (River Walk)
Hampton Inn San Antonio-Downtown (River Walk)
2.5 out of 5
414 Bowie St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the pool and the bar in our reviews. ...
8/10 Very Good! (2,254 reviews)
"Everything was great . Best value near the Riverwalk"

Reviewed on Oct 2, 2023

Hampton Inn San Antonio-Downtown (River Walk)
The St. Anthony, A Luxury Collection Hotel, San Antonio
The St. Anthony, A Luxury Collection Hotel, San Antonio
4.5 out of 5
300 E Travis St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the property condition in our reviews. ...
9/10 Wonderful! (1,001 reviews)
"It's an older property so some of the general look of the property needs updating/improvement."

Reviewed on Sep 22, 2023

The St. Anthony, A Luxury Collection Hotel, San Antonio
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the overall value and the property ...
7.6/10 Good! (2,252 reviews)
"Service with a smile polite and courteous"

Reviewed on Sep 28, 2023

La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the comfy ...
9/10 Wonderful! (2,284 reviews)
"Great breakfast"

Reviewed on Sep 30, 2023

Hotel Gibbs Downtown Riverwalk
Hotel Valencia Riverwalk
Hotel Valencia Riverwalk
4 out of 5
150 E Houston St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the bar and the property condition in our ...
8.8/10 Excellent! (1,786 reviews)
"Staff was great. Check your vehicle. Things were tampered with in mine. Overall the hotel was great. Very clean. Staff was very hospitable and friendly Step out the back and head right down to the river walk"

Reviewed on Sep 28, 2023

Hotel Valencia Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $75
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.