Hotels Near
Lake Nona Medical City

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Featured Lake Nona Medical City Hotels

DoubleTree by Hilton at the Entrance to Universal Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando
4 out of 5
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
8.2/10 Very Good! (6,264 reviews)
"Very clean and friendly staff."

Reviewed on May 22, 2025

DoubleTree by Hilton at the Entrance to Universal Orlando
Hyatt Regency Orlando International Airport
Hyatt Regency Orlando International Airport
4 out of 5
9300 Jeff Fuqua Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in Orlando. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9.4/10 Exceptional! (3,240 reviews)
"clean & comfortable. You can't beat the convienence for a late evening arrival"

Reviewed on May 22, 2025

Hyatt Regency Orlando International Airport
Holiday Inn Resort Orlando Suites - Waterpark by IHG
Holiday Inn Resort Orlando Suites - Waterpark by IHG
3.5 out of 5
14500 Continental Gateway, Orlando, FL
Fully refundable
Stay at this 3.5-star family-friendly hotel in Orlando. Enjoy 2 outdoor pools, 5 restaurants, and 2 hot tubs. Our guests praise the clean rooms and the family ...
7.2/10 Good! (3,010 reviews)
"Loved everything about this resort I didn’t have to leave for anything which I planned on doing. Will be coming back"

Reviewed on May 22, 2025

Holiday Inn Resort Orlando Suites - Waterpark by IHG
Universal's Cabana Bay Beach Resort
Universal's Cabana Bay Beach Resort
3.5 out of 5
6550 Adventure Way, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.8/10 Excellent! (5,164 reviews)
Thank you
"Friendly staff, nice pool, nice room, convenient location. But i was surprised one of the smart gates, entrance from parking to building #4, the door was broken - it looked ugly. I reported this the second morning, but by the end of the day nothing had been done, not even a 'caution' sign. I have ..."

Reviewed on May 22, 2025

Universal's Cabana Bay Beach Resort
Rosen Inn at Pointe Orlando
Rosen Inn at Pointe Orlando
3 out of 5
9000 International Drive, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3-star family-friendly hotel in Orlando. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in ...
8.4/10 Very Good! (4,425 reviews)
"The lay out was just very nice, I loved that we had the option of pool, quiet, what floor, etc. Very courteous of our needs. It felt safe there and we got precisely the room that was a perfect fit for us."

Reviewed on May 21, 2025

Rosen Inn at Pointe Orlando
Kompose Boutique Resort at Theme Parks
Kompose Boutique Resort at Theme Parks
4 out of 5
7491 W Irlo Bronson Memorial Hwy, Kissimmee, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly resort in Kissimmee. Enjoy free WiFi, free parking, and 2 hot tubs. Popular attractions Disney's Animal Kingdom® Theme ...
9.6/10 Exceptional! (137 reviews)
"This is a very nice Hotel"

Reviewed on May 23, 2025

Kompose Boutique Resort at Theme Parks
Westgate Lakes Resort & Spa Universal Studios Area
Westgate Lakes Resort & Spa Universal Studios Area
4 out of 5
9500 Turkey Lake Rd, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Orlando. Enjoy free parking, 7 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8/10 Very Good! (4,920 reviews)
"It was like our own little apt"

Reviewed on May 22, 2025

Westgate Lakes Resort & Spa Universal Studios Area
Marriott's Grande Vista
Marriott's Grande Vista
4 out of 5
5925 Avenida Vista, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Orlando. Enjoy free WiFi, 4 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. ...
8.8/10 Excellent! (2,427 reviews)
"Nice property and love tye pool"

Reviewed on May 22, 2025

Marriott's Grande Vista
Hilton Vacation Club Grande Villas Orlando
Hilton Vacation Club Grande Villas Orlando
3.5 out of 5
12118 Turtle Cay Circle, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star family-friendly hotel in Orlando. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the bar in our reviews. ...
9.2/10 Wonderful! (2,996 reviews)
"I love it."

Reviewed on May 23, 2025

Hilton Vacation Club Grande Villas Orlando
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
4 out of 5
12401 International Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in Orlando. Enjoy free WiFi, 5 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (1,647 reviews)
Give yourself a High level performance
"Yes it was more than what I was expecting and especially needed in my life. I felt like a king and very thankful."

Reviewed on May 20, 2025

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
Universal's Endless Summer Resort - Dockside Inn and Suites
Universal's Endless Summer Resort - Dockside Inn and Suites
3 out of 5
7125 Universal Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and 3 bars/lounges. Our guests praise the pool and the restaurant in ...
9/10 Wonderful! (5,188 reviews)
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Reviewed on May 22, 2025

Universal's Endless Summer Resort - Dockside Inn and Suites
Hyatt Regency Orlando
Hyatt Regency Orlando
4.5 out of 5
9801 International Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,629 reviews)
"I really enjoyed how spacious this hotel was"

Reviewed on May 20, 2025

Hyatt Regency Orlando
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Lake Nona Medical City

Orlando is a city that has a lot going on, but you have your sights set on Lake Nona Medical City. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Lake Nona Medical City has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Lake Nona Medical City hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Orlando so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Lake Nona Medical City underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Lake Nona Medical City city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Lake Nona Medical City cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Lake Nona Medical City at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Lake Nona Medical City hotel you want, book it, and never look back. Because your great escape is ahead of you.