Hotels Near
Texas Medical Center

Check Last Minute Texas Medical Center Hotel Deals

Tonight Nov 4 - Nov 5This weekend Nov 7 - Nov 9Next weekend Nov 14 - Nov 16

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Texas Medical Center Hotels

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,604 reviews)
Always stay here when in the area.

Reviewed on Nov 2, 2025

Blossom Hotel Houston, Curio Collection by Hilton
Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center

3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,077 reviews)
Convenient location. Free Shuttle to MD Anderson and other locations within 2 mi radius! Clean, friendly staff.

Reviewed on Oct 30, 2025

Hyatt Place Houston Medical Center
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,647 reviews)
Excellent staff. Front desk and room

Reviewed on Nov 2, 2025

Hilton Houston Plaza/Medical Center
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,002 reviews)
Always an incredible experience staying in this hotel

Reviewed on Oct 28, 2025

InterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
9/10 Wonderful! (1,015 reviews)
great property and excellent staff

Reviewed on Oct 29, 2025

The Westin Houston Medical Center/Museum District
Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

3 out of 5
7329 FANNIN STREET, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (1,145 reviews)
Excelent location if going to NRG Stadium.

Reviewed on Oct 28, 2025

Hyatt House Houston Medical Center
Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX

3 out of 5
6840 Almeda Rd, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
Staff was amazing as always.

Reviewed on Nov 2, 2025

Hilton Garden Inn Houston Medical Center, TX
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (2,812 reviews)
Everything is good

Reviewed on Nov 3, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
8.8/10 Excellent! (1,805 reviews)
The staff was outstanding, especially Daisy, the front desk manager and Alexandria. I had a mishap, that was soon forgotten, because of the 1st class customer service I received from these two ladies. The rooms were cozy, comfortable, and extremely clean. When the mishap, happened, I was immediately ...

Reviewed on Oct 30, 2025

Hotel Zaza Houston Museum District
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (3,874 reviews)
Check in was easy as always

Reviewed on Nov 3, 2025

Club Quarters Hotel Downtown, Houston
Heritage Place Houston Brookhollow

Heritage Place Houston Brookhollow

3 out of 5
2504 North Loop West, Houston, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (511 reviews)
Great staff, quiet, super clean and comfortable

Reviewed on Nov 3, 2025

Heritage Place Houston Brookhollow
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4 out of 5
Houston
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.2/10 Very Good! (1,288 reviews)
Yes

Reviewed on Nov 3, 2025

DoubleTree by Hilton Hotel Houston - Greenway Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Texas Medical Center

Houston is a city that has a lot going on, but you have your sights set on Texas Medical Center. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Texas Medical Center has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Texas Medical Center hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Houston so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Texas Medical Center underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Texas Medical Center city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Texas Medical Center cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Texas Medical Center at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $106
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Texas Medical Center hotel you want, book it, and never look back. Because your great escape is ahead of you.