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Last Minute Hot Rate® Hotel Deals in Houston

We Hide Hotel Names So You Can Find 4-Star Hotels At 2-Star Prices. Choose the Location, Star Rating & Amenities. Let Hotwire Find You the Best Deal. Book Today!

Choose from 6216 Houston Hotel Deals

La Quinta Inn & Suites by Wyndham Houston Bush Intl Airpt E
La Quinta Inn & Suites by Wyndham Houston Bush Intl Airpt E
2.5 out of 5
18201 Kenswick Drive, Humble, TX, 77338
  • 46 min drive from MD Anderson Cancer Center
The price is $76 per night from Aug 26 to Aug 27
Stay at this business-friendly hotel in Humble. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our ...
4.2/5 Very Good! (1,269 reviews)
"I liked the price, didn't like they don't have a pool"

Reviewed on Aug 15, 2022

La Quinta Inn & Suites by Wyndham Houston Bush Intl Airpt E
The Grand Tuscany Hotel
The Grand Tuscany Hotel
4 out of 5
12801 Northwest Fwy, Houston, TX, 77040
  • 23 min drive from MD Anderson Cancer Center
The price is $99 per night from Aug 21 to Aug 22
Stay at this 4-star family-friendly aparthotel in Houston. Enjoy free WiFi, 2 outdoor pools, and breakfast. Our guests praise the pool and the helpful staff ...
4.2/5 Very Good! (1,588 reviews)
"We went for my birthday weekend. The staff was friendly and welcoming. Such a beautiful hotel."

Reviewed on Aug 15, 2022

The Grand Tuscany Hotel
Marriott Marquis Houston
Marriott Marquis Houston
4 out of 5
1777 Walker Street, Houston, TX, 77010
  • 8 min drive from MD Anderson Cancer Center
The price is $239 per night from Aug 21 to Aug 22
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
4.2/5 Excellent! (1,003 reviews)
"Exceptional services from staff. Hotel overall very clean and comfortable. Great location!"

Reviewed on Aug 17, 2022

Marriott Marquis Houston
Cambria Hotel Houston Downtown Convention Center
Cambria Hotel Houston Downtown Convention Center
3 out of 5
1314 Texas Avenue, Houston, TX, 77002
  • 8 min drive from MD Anderson Cancer Center
The price is $116 per night from Aug 21 to Aug 22
Stay at this 3-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
4.4/5 Wonderful! (1,013 reviews)
"Excellent price, very chic boutique hotel! Beds comfy! The only negative I would say is the area around the hotel. Lots of homeless people within a block away so I didnt feel safe walking around because I was constantly asked for money. But that is the area in general, the hotel is amazing!"

Reviewed on Aug 18, 2022

Cambria Hotel Houston Downtown Convention Center
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
720 Fannin Street, Houston, TX, 77002
  • 8 min drive from MD Anderson Cancer Center
The price is $112 per night from Aug 22 to Aug 23
Stay at this 4-star business-friendly aparthotel in Houston. Enjoy free WiFi, breakfast, and room service. Our guests praise the helpful staff and the clean ...
4.1/5 Very Good! (2,196 reviews)
"Wish there was someone we could ask for help. Tv wasn’t working and needed toothbrushes."

Reviewed on Aug 17, 2022

Club Quarters Hotel Downtown, Houston
The Whitehall Houston
The Whitehall Houston
4 out of 5
1700 Smith St, Houston, TX, 77002
  • 8 min drive from MD Anderson Cancer Center
The price is $180 per night from Aug 21 to Aug 22
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, a free area shuttle, and room service. Our guests praise the helpful staff and the clean ...
4.1/5 Very Good! (1,001 reviews)
"The breakfast was nasty not worth it. The facility was beautiful staff was nice. Shower only had luke warm water"

Reviewed on Aug 18, 2022

The Whitehall Houston
Hilton Americas - Houston
Hilton Americas - Houston
4 out of 5
1600 Lamar Street, Houston, TX, 77010
  • 7 min drive from MD Anderson Cancer Center
The price is $185 per night from Sep 4 to Sep 5
Stay at this 4-star spa aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the clean ...
4.5/5 Wonderful! (1,102 reviews)
"Great property, next door to Toyota center with lots of dining options within walking distance. Friendly staff, nice big room. Very clean. We will be staying again."

Reviewed on Aug 11, 2022

Hilton Americas - Houston
Hyatt Regency Houston
Hyatt Regency Houston
4 out of 5
1200 Louisiana St, Houston, TX, 77002
  • 8 min drive from MD Anderson Cancer Center
The price is $159 per night from Aug 26 to Aug 27
Stay at this 4-star business-friendly aparthotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the ...
4.4/5 Excellent! (1,068 reviews)
Say during Anime convention
"I was able to check in at 10am which was amazing. The front desk and valet staff were very friendly and accommodating."

Reviewed on Aug 15, 2022

Hyatt Regency Houston
DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza
4 out of 5
6 Greenway Plaza East, Houston, TX, 77046
  • 4 min drive from MD Anderson Cancer Center
The price is $96 per night from Sep 5 to Sep 6
Stay at this 4-star business-friendly aparthotel in Houston. Enjoy free WiFi, a free area shuttle, and room service. Our guests praise the pool and the helpful ...
3.8/5 Good! (1,044 reviews)
"Everything very good, just need bilingual staff"

Reviewed on Aug 15, 2022

DoubleTree by Hilton Hotel Houston - Greenway Plaza
AC Hotel by Marriott Houston Downtown
AC Hotel by Marriott Houston Downtown
3.5 out of 5
723 MAIN STREET, Houston, TX, 77002
  • 9 min drive from MD Anderson Cancer Center
The price is $112 per night from Aug 28 to Aug 29
Stay at this 3.5-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the helpful staff and the ...
4.3/5 Excellent! (417 reviews)
Great stay
"Hotel was nice, clean, and has comfortable beds. Would highly recommend."

Reviewed on Aug 15, 2022

AC Hotel by Marriott Houston Downtown
Courtyard by Marriott Houston Medical Center/NRG Park
Courtyard by Marriott Houston Medical Center/NRG Park
3 out of 5
Houston Medical Center, 7702 Main Street, Houston, TX, 77030
  • 17 min walk from MD Anderson Cancer Center
The price is $93 per night from Aug 26 to Aug 27
Stay at this 3-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast, and a free area shuttle. Our guests praise the helpful staff and the clean ...
4.3/5 Excellent! (1,002 reviews)
"It was good"

Reviewed on Aug 17, 2022

Courtyard by Marriott Houston Medical Center/NRG Park
The Woodlands Resort, Curio Collection by Hilton
The Woodlands Resort, Curio Collection by Hilton
4 out of 5
2301 North Millbend Drive, The Woodlands, TX, 77380
  • 1 hour drive from MD Anderson Cancer Center
The price is $247 per night from Sep 6 to Sep 7
Stay at this 4-star golf resort in The Woodlands. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the helpful staff and the clean rooms ...
4.2/5 Excellent! (1,000 reviews)
"Family friendly and very helpful staff."

Reviewed on Aug 7, 2022

The Woodlands Resort, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Book Last Minute Hotel Deals in Houston

Space shuttles aren’t the only thing to take off in Houston. This is a city meant for explorers, adventures, and the ones who say “no thank you” to conventional travel plans. It’s a place where you can rocket yourself as far as space and as deep as hidden art installations below the ground.

Ready to leave the others in the dust? Good. Whether you’re hitting up one of the hotels near Johnson Space Center or somewhere downtown, it’s time to plant your flag in this Texas town.

Make Your Own Mission

  • Uncover the Underground Scene: Literally. Go below the surface to the Buffalo Bayou Park Cistern, a former underground drinking water reservoir. The massive space has since turned into a trippy art installation with a 17-second echo. Prefer a more traditional underground scene? Knock twice on the red door for access into Last Concert Café, a quirky space for live jams, or unlock the oddities at Notsouh (but can you guess the bar’s namesake?).

  • Breakfast of Champions: Expect some funny looks if you’re not shoving breakfast tacos down your gullet every morning. Different day? Different taco joint. Bring those dolla’ bills to Tacos Tierra Caliente, where the breakfast tacos are a $1 a pop, or hit up the drive-thru at El Rey Taqueria, which gets bonus points for letting you order in your PJs. Make your home base one of the hotels in Downtown Houston and map out your taco hop from there.

  • Burp the Bayou: See that red button at Buffalo Bayou Park? Go on, push it. Just do it! We dare you. Under the Preston Street bridge, there’s an art installation known as the Big Bubble. We can’t tell you where exactly the button is—finding it is half the fun. What is it about mysterious red buttons that make them so irresistible? Find out for yourself and discover what the heck it means to burp the bayou.

  • Full of Bull: You can’t do Houston right without a rodeo. And the Houston Livestock Show and Rodeo isn’t just any ol’ rodeo; it’s the largest rodeo in the world. No bull. It’s three weeks of country music, barbecue contests, livestock shows, and a whole lot of cowboy boots.

It’s hard not to go big in a place like Houston, which means you’re definitely not going home yet. You can choose from hotels near Minute Maid Park—watch for fly balls!—or Houston hotels near the airport. Pick a Hotwire Hot Rate, it’s like clicking your own red button, and you’ll score the biggest last-minute hotel deals in Houston.

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