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Mission Bay

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Featured Mission Bay Hotels

The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...
8.8/10 Excellent! (3,803 reviews)
Beautiful location

Reviewed on Oct 24, 2025

The Dana on Mission Bay
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,557 reviews)
The staff was personable and professional. I love the balcony view of the marina and we were in walking distance to Starbucks. :)

Reviewed on Oct 24, 2025

Hyatt Regency Mission Bay Spa and Marina
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (2,320 reviews)
Property is beautiful but just something to be aware of- it is very large and spread out so be prepared to walk a lot. They do offer golf cart rides to and from your room which was very appreciated. Service was wonderful everywhere- the staff in all areas were warm and welcoming. We had an issue ...

Reviewed on Oct 20, 2025

Paradise Point Resort & Spa
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,281 reviews)
A little outdated, beds very firm, remodeling so it’s luck if you get an updated room or an outdated one.

Reviewed on Oct 20, 2025

San Diego Mission Bay Resort
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Mission ...
9/10 Wonderful! (184 reviews)
Everyone was friendly

Reviewed on Oct 22, 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, a rooftop terrace, and parking (surcharge). Our guests praise the helpful staff ...
7.8/10 Good! (1,085 reviews)
The staff was friendly and very helpful! We also were impressed that when our ac quit working they responded immediately and helped us change rooms within minutes. The friendly service was above and beyond our expectations.

Reviewed on Oct 24, 2025

Comfort Inn San Diego Airport At The Harbor
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
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Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,839 reviews)
Staff were incredibly kind and helpful, the market one location was extremely convenient with a great selection of food and drink. My room had a wonderful view as well as being very clean. Overall very pleased with my experience and would definitely stay there again.

Reviewed on Oct 22, 2025

Manchester Grand Hyatt San Diego
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,091 reviews)
I am very happy

Reviewed on Oct 23, 2025

Hilton San Diego Mission Valley
Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,002 reviews)
The rooms were very nice and the location is perfect for San Diego. It's a very nice hotel.

Reviewed on Oct 22, 2025

Pendry San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,991 reviews)
Had a very nice time very satisfied definitely recommend

Reviewed on Oct 23, 2025

Wyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (3,009 reviews)
Place was very simple no amenities

Reviewed on Oct 20, 2025

Hard Rock Hotel San Diego
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

4 out of 5
11915 El Camino Real, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,712 reviews)
very nice and safe area, clean and quiet rooms

Reviewed on Oct 24, 2025

DoubleTree by Hilton San Diego - Del Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Mission Bay

San Diego is a city that has a lot going on, but you have your sights set on Mission Bay. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Mission Bay has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Mission Bay hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Mission Bay underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Mission Bay city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Mission Bay cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Mission Bay at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $89
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Mission Bay hotel you want, book it, and never look back. Because your great escape is ahead of you.