Hotels Near
Greater South Side

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Featured Greater South Side Hotels

Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave, Des Moines, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,640 reviews)
Very friendly staff and convenient location.

Reviewed on Oct 27, 2025

Days Inn & Suites by Wyndham Des Moines Airport
AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport

2.5 out of 5
1920 Hackley Ave, Des Moines, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,015 reviews)
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Reviewed on Oct 21, 2025

AmericInn by Wyndham Des Moines Airport
Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport

2.5 out of 5
5001 Fleur Dr, Des Moines, IA
Fully refundableReserve now, pay when you stay
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.8/10 Excellent! (1,001 reviews)
Pleasant stay

Reviewed on Oct 23, 2025

Hampton Inn Des Moines-Airport
Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport

2.5 out of 5
5231 Fleur Dr, Des Moines, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (1,000 reviews)
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Reviewed on Oct 21, 2025

Quality Inn & Suites Des Moines Airport
Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG

3 out of 5
6111 Fleur Dr, Des Moines, IA
Fully refundable
Stay at this 3-star hotel in Des Moines. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the room service in ...
8.2/10 Very Good! (576 reviews)
Wonderfully friendly staff.

Reviewed on Sep 30, 2025

Holiday Inn Des Moines-Airport/Conf Center by IHG
Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

2.5 out of 5
7225 Vista Dr, West Des Moines, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,041 reviews)
While in road trip stopped for the night very nice staff, good food comfy clean room.

Reviewed on Oct 23, 2025

Fairfield Inn and Suites by Marriott Des Moines West
Hotel Fort Des Moines, Curio Collection by Hilton

Hotel Fort Des Moines, Curio Collection by Hilton

4.5 out of 5
1000 Walnut St, Des Moines, IA
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Des Moines. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (1,030 reviews)
Couldn’t fine a Coke machine

Reviewed on Oct 22, 2025

Hotel Fort Des Moines, Curio Collection by Hilton
Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University

3 out of 5
2650 University Ave., Des Moines, IA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,011 reviews)
Good

Reviewed on Oct 27, 2025

Home2 Suites by Hilton Des Moines at Drake University
Sonesta Essential Des Moines

Sonesta Essential Des Moines

2 out of 5
4755 Merle Hay Road, Des Moines, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,003 reviews)
Overall good stay, unfortunately the fridge did not work in my room, and there was no actual warm breakfast like there was in the past. But for the price and cleanliness I'll be back.

Reviewed on Oct 27, 2025

Sonesta Essential Des Moines
Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
Fully refundableReserve now, pay when you stay
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.6/10 Good! (628 reviews)
Yes

Reviewed on Oct 22, 2025

Motel 6 West Des Moines, IA
Stoney Creek Hotel Des Moines - Johnston

Stoney Creek Hotel Des Moines - Johnston

2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,763 reviews)
Clean rooms. Pool was great but a little chilly. Staff were prompt.

Reviewed on Oct 18, 2025

Stoney Creek Hotel Des Moines - Johnston
Des Lux Hotel

Des Lux Hotel

3.5 out of 5
800 Locust St, Des Moines, IA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
9.6/10 Exceptional! (1,040 reviews)
We didn't eat breakfast

Reviewed on Oct 27, 2025

Des Lux Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Greater South Side

Des Moines is a city that has a lot going on, but you have your sights set on Greater South Side. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Greater South Side has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Greater South Side hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Des Moines so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Greater South Side underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Greater South Side city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Greater South Side cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Greater South Side at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $62
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Greater South Side hotel you want, book it, and never look back. Because your great escape is ahead of you.