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Choose from 389 De Soto Hotel Deals

Edgetowner Motel
Reviewed on Apr 21, 2025

Days Inn & Suites by Wyndham Des Moines Airport
Reviewed on Jul 27, 2025

Motel 6 West Des Moines, IA
Reviewed on Jul 28, 2025

Days Inn by Wyndham West Des Moines / Clive
Reviewed on Jul 29, 2025

Sonesta Essential Des Moines
Reviewed on Jul 26, 2025

Stoney Creek Hotel Des Moines - Johnston
Reviewed on Jul 25, 2025

Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Reviewed on Jul 19, 2025

Wildwood Lodge
Reviewed on Jul 28, 2025

Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton
Reviewed on Jul 27, 2025

Quality Inn & Suites Des Moines - Merle Hay Road
Reviewed on Jul 28, 2025

GrandStay Hotel & Suites
Reviewed on Jul 26, 2025

Drury Inn & Suites West Des Moines
Reviewed on Jul 28, 2025
Find cheap hotels in De Soto
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in De Soto.
Choosing the right hotel in Iowa has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of De Soto’s 389 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $56. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great De Soto hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in De Soto. No matter your reason for visiting De Soto, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About De Soto hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in De Soto?
With over 389 hotels in De Soto, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $56.
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Finding a cheap car rental deal in De Soto is as easy as scoring cheap hotels in De Soto. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
Top Booked Hotels in De Soto
- Days Inn & Suites by Wyndham Des Moines Airport
- Motel 6 West Des Moines, IA
- Days Inn by Wyndham West Des Moines / Clive
- Sonesta Essential Des Moines
- Stoney Creek Hotel Des Moines - Johnston
- Ramada Tropics Resort & Conf Center by Wyndham Des Moines
- Wildwood Lodge
- Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton
- Quality Inn & Suites Des Moines - Merle Hay Road
- Hyatt Place West Des Moines Jordan Creek
- Hampton Inn Des Moines-Airport
- Days Inn by Wyndham West Des Moines
- AmericInn by Wyndham Johnston Des Moines
- Hotels near Jordan Creek Town Center
- Hotels near Drake University
- Hotels near Living History Farms
- Hotels near Val Air Ballroom
- Hotels near Des Moines Art Center
- Hotels near Merle Hay Mall
- Hotels near West Glen Town Center
- Hotels near Lauridsen Amphitheater
- Hotels near Valley Junction
- Hotels near Salisbury House
- Hotels near Des Moines MEPS
- Hotels near Mercy Medical Center West Lakes
- Hotels near Roseman Bridge
- Hotels near Walnut Woods State Park
- Hotels near Raccoon River Park
- Hotels near John Wayne Birthplace Museum
- Hotels near Water Works Park
- Hotels near Sky Zone Indoor Trampoline Park
- Hotels near Valley West Mall
- Hotels near Raccoon River Valley Trail
- West Des Moines Hotels
- Urbandale Hotels
- Johnston Hotels
- Waukee Hotels
- Clive Hotels
- Indianola Hotels
- Winterset Hotels
- Grimes Hotels
- Norwalk Hotels
- Stuart Hotels
- Adel Hotels
- Panora Hotels
- Perry Hotels
- Cumming Hotels
- Van Meter Hotels
- Windsor Heights Hotels
- Guthrie Center Hotels
- Central United States Hotels
- Greenfield Hotels