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Hotels in Central United States

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Choose from 301949 Central United States Hotel Deals

Gaylord Opryland Resort & Convention Center

Gaylord Opryland Resort & Convention Center

4 out of 5
2800 Opryland Drive Nashville TN
  • 18 hours drive from River Walk
Book a stay at this spa resort in Nashville. Enjoy 2 outdoor pools, a full-service spa, and 18 restaurants. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,764 reviews)
Great stay

Reviewed on Dec 27, 2025

Gaylord Opryland Resort & Convention Center
Hilton Chicago

Hilton Chicago

4 out of 5
720 S Michigan Ave Chicago IL
  • 37 hours drive from River Walk
Book a stay at this historic hotel in Chicago. Enjoy 2 restaurants, breakfast (surcharge), and a health club. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (2,416 reviews)
Very friendly staff.

Reviewed on Dec 26, 2025

Hilton Chicago
Hilton Chicago/Magnificent Mile Suites

Hilton Chicago/Magnificent Mile Suites

3.5 out of 5
198 E Delaware Pl Chicago IL
  • 37 hours drive from River Walk
Book a stay at this business-friendly hotel in Chicago. Enjoy a fitness center, valet parking (surcharge), and a 24-hour front desk. Our guests praise the helpful ...
8.8/10 Excellent! (3,562 reviews)
Great front desk service

Reviewed on Dec 25, 2025

Hilton Chicago/Magnificent Mile Suites
Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

4 out of 5
17 E Monroe St Chicago IL
  • 37 hours drive from River Walk
Book a stay at this luxury hotel in Chicago. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
8.4/10 Very Good! (2,192 reviews)
The service at the front desk!

Reviewed on Dec 28, 2025

Palmer House a Hilton Hotel
The Westin New Orleans

The Westin New Orleans

4.5 out of 5
100 Rue Iberville New Orleans LA
Book a stay at this luxury hotel in New Orleans. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (2,315 reviews)
Room was very clean, great location, everything was in walking distance. The only issue was not all the elevators were functional to get to the lobby from street level. Lobby bar was always a fun first stop to start your night.

Reviewed on Dec 27, 2025

The Westin New Orleans
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
  • 2 hours drive from River Walk
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (3,163 reviews)
Everything exceeded our expectations

Reviewed on Dec 27, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Wacker at Michigan, Chicago

Club Quarters Hotel Wacker at Michigan, Chicago

4 out of 5
75 E Wacker Dr Chicago IL
  • 37 hours drive from River Walk
Book a stay at this business-friendly hotel in Chicago. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (2,018 reviews)
Room was clean. The toilet clog and had to ask them 3 times to fix it. The heat in the room was broken they gave us a space heater

Reviewed on Dec 28, 2025

Club Quarters Hotel Wacker at Michigan, Chicago
New Orleans Marriott

New Orleans Marriott

4 out of 5
555 Canal St New Orleans LA
Book a stay at this business-friendly hotel in New Orleans. Enjoy 2 restaurants, breakfast (surcharge), and room service. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,747 reviews)
Amazing room amd view. Super clean

Reviewed on Dec 27, 2025

New Orleans Marriott
Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North

4 out of 5
600 N State St Chicago IL
  • 37 hours drive from River Walk
Stay at this hotel in Chicago. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the pool in our reviews. Popular ...
8.4/10 Very Good! (5,476 reviews)
Good breakfast.

Reviewed on Dec 30, 2025

Embassy Suites by Hilton Chicago Downtown River North
Comfort Inn Downtown Nashville - Music City Center

Comfort Inn Downtown Nashville - Music City Center

3 out of 5
1501 Demonbreun St Nashville TN
  • 18 hours drive from River Walk
Book a stay at this business-friendly hotel in Nashville. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the pool ...
8/10 Very Good! (3,393 reviews)
The room was clean. The room was a little dated and small, but we made it ok.

Reviewed on Dec 29, 2025

Comfort Inn Downtown Nashville - Music City Center
The Pfister Hotel

The Pfister Hotel

4.5 out of 5
424 E Wisconsin Ave Milwaukee WI
  • 35 hours drive from River Walk
Book a stay at this luxury hotel in Milwaukee. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (1,848 reviews)
Rooms were great

Reviewed on Dec 29, 2025

The Pfister Hotel
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
  • 2 hours drive from River Walk
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (3,971 reviews)
Great hotel

Reviewed on Dec 27, 2025

Club Quarters Hotel Downtown, Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central United States

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central United States.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central United States’s 301,949 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $84. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central United States hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central United States. No matter your reason for visiting Central United States, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central United States hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Central United States for as low as $84.

How many hotels are there in Central United States?

With over 301,949 hotels in Central United States, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $84.

How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.