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Hotels in Central United States

Choose from 174743 Central United States Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX, 78202
  • 26 hours drive from Great Smoky Mountains National Park
The price is $98 per night from May 22 to May 23
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the clean rooms in our reviews. ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Congress Plaza Hotel
Congress Plaza Hotel
3.5 out of 5
520 South Michigan Avenue, Chicago, IL, 60605
  • 18 hours drive from Great Smoky Mountains National Park
The price is $152 per night from Jun 7 to Jun 8
Stay at this 3.5-star business-friendly hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Congress Plaza Hotel
The Grand Tuscany Hotel
The Grand Tuscany Hotel
4 out of 5
12801 Northwest Fwy, Houston, TX, 77040
  • 16 hours drive from Great Smoky Mountains National Park
The price is $99 per night from May 22 to May 23
Stay at this 4-star family-friendly hotel in Houston. Enjoy free WiFi, 2 outdoor pools, and breakfast. Our guests praise the pool and the helpful staff in our ...
The Grand Tuscany Hotel
21c Museum Hotel Chicago
21c Museum Hotel Chicago
4 out of 5
55 East Ontario Street, Chicago, IL, 60611
  • 18 hours drive from Great Smoky Mountains National Park
The price is $189 per night from May 30 to May 31
Stay at this 4-star spa hotel in Chicago. Enjoy free WiFi, a full-service spa, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
21c Museum Hotel Chicago
Royal Sonesta Chicago Downtown
Royal Sonesta Chicago Downtown
4 out of 5
71 E Wacker Dr, Chicago, IL, 60601
  • 18 hours drive from Great Smoky Mountains National Park
The price is $189 per night from May 30 to May 31
Stay at this 4-star business-friendly hotel in Chicago. Enjoy room service, a 24-hour fitness center, and valet parking. Our guests praise the helpful staff ...
Royal Sonesta Chicago Downtown
Warwick Allerton - Chicago
Warwick Allerton - Chicago
4 out of 5
701 North Michigan Avenue, Chicago, IL, 60611
  • 18 hours drive from Great Smoky Mountains National Park
The price is $135 per night from May 30 to May 31
Stay at this 4-star family-friendly hotel in Chicago. Enjoy WiFi, a 24-hour fitness center, and valet parking. Our guests praise the helpful staff and the clean ...
Warwick Allerton - Chicago
LondonHouse Chicago, Curio Collection by Hilton
LondonHouse Chicago, Curio Collection by Hilton
4.5 out of 5
85 East Wacker Drive, Chicago, IL, 60601
  • 18 hours drive from Great Smoky Mountains National Park
The price is $229 per night from May 30 to May 31
Stay at this 4.5-star luxury hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
LondonHouse Chicago, Curio Collection by Hilton
Eurostars Magnificent Mile
Eurostars Magnificent Mile
4 out of 5
660 North State Street, Chicago, IL, 60654
  • 18 hours drive from Great Smoky Mountains National Park
The price is $180 per night from May 30 to May 31
Stay at this 4-star boutique hotel in Chicago. Enjoy free WiFi, breakfast, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Eurostars Magnificent Mile
Best Western River North Hotel
Best Western River North Hotel
2.5 out of 5
125 W Ohio St, Chicago, IL, 60654
  • 18 hours drive from Great Smoky Mountains National Park
The price is $141 per night from May 31 to Jun 1
Stay at this hotel in Chicago. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the helpful staff and the overall value in our reviews. Popular ...
Best Western River North Hotel
The St. Clair Hotel – Magnificent Mile
The St. Clair Hotel – Magnificent Mile
2.5 out of 5
162 East Ontario Street, Chicago, IL, 60611
  • 18 hours drive from Great Smoky Mountains National Park
The price is $139 per night from May 18 to May 19
Stay at this hotel in Chicago. Enjoy free WiFi, room service, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
The St. Clair Hotel – Magnificent Mile
The Whitehall Hotel
The Whitehall Hotel
4 out of 5
105 E Delaware Pl, Chicago, IL, 60611
  • 18 hours drive from Great Smoky Mountains National Park
The price is $116 per night from May 18 to May 19
Stay at this 4-star boutique hotel in Chicago. Enjoy free WiFi, room service, and a fitness center. Our guests praise the clean rooms and the overall value in ...
The Whitehall Hotel
DoubleTree by Hilton Chicago - Magnificent Mile
DoubleTree by Hilton Chicago - Magnificent Mile
4 out of 5
300 E Ohio St, Chicago, IL, 60611
  • 18 hours drive from Great Smoky Mountains National Park
The price is $174 per night from May 30 to May 31
Stay at this 4-star business-friendly hotel in Chicago. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the clean rooms in our reviews. ...
DoubleTree by Hilton Chicago - Magnificent Mile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Central United States

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Central United States hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central United States.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central United States’s 174743 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $98. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Central United States hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central United States. No matter your reason for visiting Central United States, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central United States hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Central United States for as low as $98.

How many hotels are there in Central United States?

With over 174743 hotels in Central United States, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $98.

How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Central United States now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Central United States right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.

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