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Featured Sikeston Family Hotels
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd, Jackson, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
Fully refundable
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Dexter Inn
1807 W Business US Highway 60, Dexter, MO
Fully refundable
Stay at this hotel in Dexter. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions The ...
Quality Inn Charleston - Sikeston
102 Drake St, I-57 Exit 10, Charleston, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Sikeston
Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
"Very nice property, very clean. Staff was fabulous when I requested a room away from the elevator due to noise. It wasn't super loud I just preferred somewhere further down hallway."
Reviewed on Sep 28, 2025
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Very nice and quiet"
Reviewed on Sep 30, 2025
Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,018 reviews)
"Awesome daily breakfast, and dinner, included with stay. Quiet and comfortable room. My first stay, at a Drury property, and certainly not my last."
Reviewed on Sep 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Sikeston
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Sikeston
- Pet-friendly Hotels in Sikeston
- Hotels with a Pool in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with Hot Tubs in Sikeston
- Casinos in Sikeston
- Luxury Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Apartment Hotel in Sikeston
- Historic Hotels in Sikeston
Top Points of Interests in Sikeston
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Big Oak Tree State Park
- Hotels near eDen Spa & Salon
- Hotels near New Madrid Historical Museum
- Hotels near Mound City National Cemetery
- Hotels near Fort Defiance State Park
- Hotels near The Heritage House
- Hotels near Fort D Historic Site
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Marston Community Center
- Hotels near Front Street Studio & Art Gallery
- Hotels near Hunter-Dawson State Historic Site
- Hotels near River Ridge Winery
Cities near Sikeston
- Cape Girardeau Hotels (29.82 mi)
- Ozarks Hotels (161.27 mi)
- Southern Illinois Hotels (113.94 mi)
- Cairo Hotels (24.44 mi)
- Southeastern United States Hotels (420.75 mi)
- Dexter Hotels (21.18 mi)
- Tiptonville Hotels (35.09 mi)
- Charleston Hotels (13.59 mi)
- Southeast Missouri Hotels (51.94 mi)
- Marston Hotels (24.82 mi)
- Western Tennessee Hotels (89.28 mi)
- New Madrid Hotels (20.41 mi)
- Portageville Hotels (31.83 mi)
- Western Kentucky Hotels (109.03 mi)
- The South Hotels (242.82 mi)
- Malden Hotels (30.43 mi)
- East Prairie Hotels (13.15 mi)
- Central United States Hotels (267.86 mi)
- Bloomfield Hotels (18.77 mi)