Search for Cheap Deals on
Hotels in Cape Girardeau

Photo by Skyy

Choose from 162 Cape Girardeau Hotel Deals

The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
  • 18 min walk from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (369 reviews)
"A very cool destination!"

Reviewed on Aug 1, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,004 reviews)
"The property was clean and well staffed. They offered various food and drink options from the time we checked in until the time we checked out. Great staff great hotel and a wonderful experience!"

Reviewed on Aug 1, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,002 reviews)
Great Hotel for the Price
"My family was driving back from vacation and needed a last minute place to rest for the night. It was overall a great stay for the price. They had a portable crib for my toddler along with popcorn in the lobby. The staff were friendly and accommodating. Lots of choices for nearby restaurants."

Reviewed on Aug 3, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,006 reviews)
"Rooms are very nice and spacious. Liked the welcome cookies. Breakfast buffet had lots of options!"

Reviewed on Aug 3, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,002 reviews)
Good stay
"Good location, right off the interstate and close to stores and food. They are in the process of remodeling so hard to determine how nice it will be upon completion. Room was clean. Would stay here again."

Reviewed on Aug 2, 2025

Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (833 reviews)
Air con very efficient
"Room was lovely. Air con very cold and loud"

Reviewed on Jul 17, 2025

Candlewood Suites Cape Girardeau by IHG
Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
  • 9 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (618 reviews)
"A/c unit"

Reviewed on Jul 24, 2025

Quality Inn
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
  • 12 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.4/10 Exceptional! (51 reviews)
"The stay was great. Friendly staff. Very helpful. Great breakfast options. Bed was more comfortable than a lot of hotels I've stayed in. They had a pool table and a good selection of board games and things to do as a family. That was great. There were only 2 things I wish were a little better. The ..."

Reviewed on Aug 4, 2025

Tru By Hilton Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St., Cape Girardeau, MO
  • 14 min walk from Southeast Missouri State University
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.4/10 Exceptional! (434 reviews)
"Great place to stay. It’s very beautiful."

Reviewed on Jul 26, 2025

Courtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (965 reviews)
"Much improved from last year"

Reviewed on Aug 2, 2025

Drury Inn & Suites Cape Girardeau
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 out of 5
207 S Mt Auburn Rd, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.6/10 Exceptional! (733 reviews)
"Great place to stay."

Reviewed on Jul 28, 2025

Hampton Inn Cape Girardeau I 55 East
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 out of 5
433 CAPE WEST CROSSINGS, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.2/10 Wonderful! (115 reviews)
"New hotel, staff was very friendly and helpful"

Reviewed on Jul 1, 2025

Fairfield Inn & Suites by Marriott Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Cape Girardeau

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Cape Girardeau hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Cape Girardeau.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Cape Girardeau’s 162 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $70. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Cape Girardeau hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Cape Girardeau. No matter your reason for visiting Cape Girardeau, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Cape Girardeau hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Cape Girardeau for as low as $70.

How many hotels are there in Cape Girardeau?

With over 162 hotels in Cape Girardeau, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $70.

How to find cheap car rentals in Cape Girardeau?

Finding a cheap car rental deal in Cape Girardeau is as easy as scoring cheap hotels in Cape Girardeau. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.