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Choose from 108 Charleston Hotel Deals
The Riverstone Hotel Charleston-Sikeston
Super 8 by Wyndham Charleston/Sikeston East MO
Eagle Inn Charleston
"Don’t go here if you’re a single woman traveling alone. I did not feel save even with my dog."
Reviewed on Aug 27, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
"Everything was great service, clean and very friendly staff only complaint is the bed was super uncomfortable but that’s not the hotel employees faults ):"
Reviewed on Nov 11, 2026
Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Sikeston, MO
"The hotel was very clean. Room was spacious and bed was comfortable. Staff were friendly"
Reviewed on Nov 6, 2026
The Riverview
Days Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Cape Girardeau
Candlewood Suites Cape Girardeau by IHG
Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Cape Girardeau
"I didn't get the receptionist's name, but she was absolutely wonderful! As we were leaving today after our 2-night stay, she asked if we needed ice for our cooler, and then proceeded to fill our cooler with ice and carried it out to our vehicle. So very, very kind, and very much appreciated."
Reviewed on Nov 8, 2026
Find cheap hotels in Charleston
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Charleston hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Charleston.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Charleston’s 108 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Charleston hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Charleston. No matter your reason for visiting Charleston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Charleston hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Charleston for as low as $66.
How many hotels are there in Charleston?
With over 108 hotels in Charleston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.
How to find cheap car rentals in Charleston?
Finding a cheap car rental deal in Charleston is as easy as scoring cheap hotels in Charleston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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