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Choose from 690 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
Comfort Inn Festus - St Louis South
"I booked a room with a full kitchen and got there and didn’t have it. They moved me to a room that did with different types of beds. I specifically booked this room to work in for several days and it was listed with cookware, plates, silverware and cups. It had none. There was an oven but nothing ..."
Reviewed on Sep 7, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"When we arrived, the entire first floor wreaked of weed. Yuck! Our bathroom light flashed off and on constantly. Our coffee maker did not work. I did not like the breakfast! Usually I can toast a bagel or English muffin. None to be found. I could not get a glass of water to take my meds. Very duu ..."
Reviewed on Sep 6, 2026
Pear Tree Inn Cape Girardeau West
"Staff very friendly and helpful! Breakfast great and breakfast staff very friendly ! Bed comfortable. Showe gel , shampoo and conditioner on shower wall. Only thing missing was hair dryer. Microwave and fridge in room. Great stay"
Reviewed on Sep 7, 2026
The Riverview
"The hotel was very nice with two exceptions; 1) there was a huge cobweb in my room. I noticed it on the first day, I notified the front desk, and they said they would 'take care of it.' The next afternoon, the cobweb was still there so I contacted the front desk again and the person said "oh yeah, ..."
Reviewed on Sep 7, 2026
Drury Inn & Suites Sikeston, MO
"This was my second time staying at Drury hotel. I will most definitely book another stay."
Reviewed on Sep 6, 2026
Drury Inn & Suites Hayti Caruthersville
"Probably the best Drury inn I've been to. Pool and hot tube both crystal clear. Food was great. Staff was interested and engaged. Room and facility very clean. Nice job guys!"
Reviewed on Sep 5, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
"This place was awesome hands down! The staff was extremely accommodating and friendly. Thank you Madison for a great check in experience. Of all the hotels we stayed at over our road trip this weekend this was the best deal and the nicest establishment by far. The receptionist even gave my children ..."
Reviewed on Sep 7, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"This was my first time camping and I will say that I will definitely return. It was an amazing experience and the workers were soooooooo amazingly nice and accommodating. I will be telling everyone about these hidden gem."
Reviewed on Sep 7, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
"Comfortable and convenient"
Reviewed on Sep 6, 2026
Holiday Inn Poplar Bluff by IHG
The Farmstead Hotel
Find cheap hotels in Southeast Missouri
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 690 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $62.
How many hotels are there in Southeast Missouri?
With over 690 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
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- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Southeast Missouri State University
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Ozark National Scenic Riverways
- Hotels near Taum Sauk Mountain State Park
- Hotels near Current River State Park
- Hotels near Century Casino Caruthersville
- Hotels near Echo Bluff State Park
- Hotels near Big Spring
- Hotels near Lake Wappapello
- Hotels near Alley Spring & Mill
- Hotels near Akers Ferry
- Hotels near Rocky Falls
- Hotels near Sainte Genevieve Winery
- Hotels near St. Joe State Park
- Hotels near St. Francois State Park
- Hotels near K Bridge Recreation Area
- Hotels near Hawn State Park
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Hotels with Free Parking in Southeast Missouri
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- Chesterfield Hotels
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- Cape Girardeau Hotels
- Eminence Hotels
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- Fenton Hotels
- Poplar Bluff Hotels
- Sikeston Hotels
- Richmond Heights Hotels
- Eureka Hotels
- Farmington Hotels
- East St. Louis Hotels
- Kirkwood Hotels
- Van Buren Hotels
- Valley Park Hotels
- Arnold Hotels
- Perryville Hotels
- West Plains Hotels
- Cuba Hotels
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