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Choose from 662 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO
"This is our go to hotel when we come to visit my parents!"
Reviewed on Jul 22, 2026
The Riverview
"Such a great place in fact it was so nice I stayed a few more nights, the casino is amazing"
Reviewed on Jul 22, 2026
Drury Inn & Suites Sikeston, MO
"Some gluten free selections (muffins and/or bread) would be nice."
Reviewed on Jul 22, 2026
Drury Inn & Suites Hayti Caruthersville
"This was an easy stay. Hotel seems to be older but comfortable. Easy parking. breakfast and wind down we're not used as we arrived late and left early. Staff excellent."
Reviewed on Jul 22, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
"The hotel was very clean. Staff were helpful and friendly."
Reviewed on Jul 21, 2026
Motel 6 Poplar Bluff, MO
"Clean room and wonderful staff!"
Reviewed on Jul 22, 2026
Pear Tree Inn Cape Girardeau West
"We enjoyed our stay. The staff was very kind. The facility is clean and the bed is comfortable. The pillows are small, but there are 5 on the bed, so it works out. If you have food allergies - such as dairy, the breakfast will not be available to you."
Reviewed on Jul 20, 2026
Comfort Inn Festus - St Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"Location of the hotel was great for our needs - lots of restaurants very close by. The pool was great after a long day of driving. Breakfast was good, although very heavy on sweets, pastries, and truly just desserts (cookies, rice crispy treats). The chairs in the breakfast area badly needed replaced. ..."
Reviewed on Jul 23, 2026
The Farmstead Hotel
"Total new experience no person at desk till 11PM. You need to go to casino desk approximately 100 yards away sign in, get room card for outside doors will not open without it. If you are just road traveling not going for casino not worth the good price to me."
Reviewed on Jul 23, 2026
Best Western Plus Sikeston I-55
"Clean and comfortable room with good free breakfast"
Reviewed on Jul 18, 2026
Find cheap hotels in Southeast Missouri
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 662 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $63.
How many hotels are there in Southeast Missouri?
With over 662 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Current River State Park
- Hotels near Century Casino Caruthersville
- Hotels near Echo Bluff State Park
- Hotels near Taum Sauk Mountain State Park
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Lake Wappapello
- Hotels near Akers Ferry
- Hotels near Rocky Falls
- Hotels near K Bridge Recreation Area
- Hotels near Sainte Genevieve Winery
- Hotels near St. Francois State Park
- Hotels near Black River Coliseum
- Hotels near Round Spring Cave
- Hotels near Riverfront Bridge Park
- Hotels with Free Parking in Southeast Missouri
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