Search for Cheap Deals on
Hotels in Southeast Missouri

Choose from 657 Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,011 reviews)
Was a great stay!

Reviewed on May 11, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
  • 2 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,013 reviews)
Great Job!

Reviewed on May 8, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,016 reviews)
Great travel hotel from Texas to Chicago.

Reviewed on May 11, 2026

Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (566 reviews)
I love these hotel rooms because they’re very spacious, bright and clean!

Reviewed on May 9, 2026

The Riverview
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (557 reviews)
Everything was good

Reviewed on May 10, 2026

Hampton Inn Sikeston
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (762 reviews)
Nice hotel

Reviewed on May 10, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (182 reviews)
The hotel room was very clean and the beds were comfortable, which made for a good night’s sleep. The staff was friendly and the overall stay was pleasant. The only downside was the breakfast. The food selection was limited and the quality was disappointing. Other than breakfast, the hotel experience ...

Reviewed on May 11, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,009 reviews)
peaceful

Reviewed on May 11, 2026

Drury Inn & Suites Jackson MO
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,016 reviews)
Loved the night meal as well as breakfast. What a treat!

Reviewed on May 11, 2026

Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,008 reviews)
People were allowed to party and laugh and rev their engines outside our room. When we complained to the front desk we were told that they are just relaxing. after a second call to the desk they finally went to their room where they played loud music. The desk showed no interest in helping us. All ...

Reviewed on May 10, 2026

Pear Tree Inn Cape Girardeau West
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.6/10 Exceptional! (506 reviews)
Wow! Zero complaints. Perfect stay. Great value.

Reviewed on May 7, 2026

Courtyard by Marriott Cape Girardeau Downtown
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
  • 3 hours drive from Mark Twain National Forest
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (836 reviews)
Friendly staff. Clean room and facilities. Convenient location. Easy parking.

Reviewed on May 9, 2026

Hampton Inn Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 657 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southeast Missouri hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $63.

How many hotels are there in Southeast Missouri?

With over 657 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.

How to find cheap car rentals in Southeast Missouri?

Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.