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Hotels in Southeast Missouri

Check Last Minute Southeast Missouri Hotel Deals

Tonight Aug 20 - Aug 21Next weekend Aug 26 - Aug 28

Choose from 339 Southeast Missouri Hotel Deals

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $67 per night from Aug 24 to Aug 25
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
4.3/5 Excellent! (990 reviews)
"Staff were lovely and the room was comfortable and clean"

Reviewed on Aug 10, 2022

Pear Tree Inn Cape Girardeau West
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO, 63901
  • 2 hours drive from Johnson's Shut-ins State Park
The price is $70 per night from Aug 21 to Aug 22
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.1/5 Very Good! (1,000 reviews)
"clean and good area for the price"

Reviewed on Aug 1, 2022

Motel 6 Poplar Bluff, MO
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $112 per night from Aug 24 to Aug 25
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
4.8/5 Exceptional! (782 reviews)
"Our stay was perfect. The kids really enjoyed the perks…free popcorn and soda, free 5:30 kick back and the free breakfast. All were a hit. Our only issue was the fridge was not cold. We will definitely stay again when we come to Cape!"

Reviewed on Aug 15, 2022

Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 out of 5
3253 William Street, Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $112 per night from Aug 28 to Aug 29
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
4.7/5 Exceptional! (859 reviews)
Clean
"very clean and friendly staff. would definitely stay at this location again."

Reviewed on Aug 1, 2022

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Auburn Place Hotel And Suites
Auburn Place Hotel And Suites
2.5 out of 5
3265 William St, Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $79 per night from Aug 21 to Aug 22
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
4.3/5 Excellent! (1,001 reviews)
Great Place
"We stayed just one night but the hotel was nice and clean. Great location for food and shopping."

Reviewed on Aug 16, 2022

Auburn Place Hotel And Suites
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Sikeston, MO, 63801
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $108 per night from Sep 5 to Sep 6
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
4.6/5 Exceptional! (1,000 reviews)
"The room was clean and spacious. The staff was very friendly and helpful. Breakfast was amazing!!!"

Reviewed on Aug 8, 2022

Drury Inn & Suites Sikeston, MO
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3 out of 5
400 Broadway St., Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $119 per night from Aug 21 to Aug 22
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean ...
4.7/5 Exceptional! (251 reviews)
"The hotel was very clean and the staff was very friendly. Our room had cold AC, which is great considering the temps. Our only complaint is the mattress was a bit uncomfortable."

Reviewed on Aug 5, 2022

Courtyard by Marriott Cape Girardeau Downtown
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
2.5 out of 5
1001 Veterans Blvd, Festus, MO, 63028
  • 2 hours drive from Johnson's Shut-ins State Park
The price is $84 per night from Aug 28 to Aug 29
Stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our ...
4/5 Very Good! (409 reviews)
A nice hotel
"Easy check in, key cards worked the first time, room was clean and properly stocked, air conditioning worked well, shower was hot and had decent water flow, and the bed was comfortable. Received a text asking if we needed anything, which was a nice touch. Breakfast was okay. We went down at 8:40 ..."

Reviewed on Aug 10, 2022

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO, 63801
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $89 per night from Aug 21 to Aug 22
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
4.2/5 Very Good! (871 reviews)
"Comfortable room. Small indoor pool. Laundry facility. Breakfast. Made for a very good stay for our family."

Reviewed on Aug 10, 2022

Best Western Plus Sikeston
Quality Inn Festus
Quality Inn Festus
3 out of 5
1200 W Gannon Dr, Festus, MO, 63028
  • 2 hours drive from Johnson's Shut-ins State Park
The price is $67 per night from Aug 21 to Aug 22
Stay at this 3-star family-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the bar and the helpful staff in our ...
3.5/5 Good! (770 reviews)
Comfortable Stay
"The hotel is old and has a large conference area or ball room that needs renovation. The rooms are comfortable and clean and a nice size. We did not use the pool. The area had a lot of shops and restaurants. We were satisfied with the room and the service."

Reviewed on Jul 19, 2022

Quality Inn Festus
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO, 63701
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $67 per night from Aug 24 to Aug 25
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and ...
4.4/5 Excellent! (1,002 reviews)
5 stars!
"Front desk lady was super nice and friendly! Helped us make our waffles and didnt get mad when we spilled our cereal!!! Shes so sweet! Ended up extending and she was just pleasant the whole stay! Room was clean and comfortable!"

Reviewed on Aug 16, 2022

Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO, 63801
  • 4 hours drive from Johnson's Shut-ins State Park
The price is $81 per night from Sep 1 to Sep 2
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff ...
4.6/5 Exceptional! (998 reviews)
"Clean hotel all the way around, friendly and Helpful staff."

Reviewed on Aug 15, 2022

Pear Tree Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Southeast Missouri

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 339 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southeast Missouri hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southeast Missouri hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $67.

How many hotels are there in Southeast Missouri?

With over 339 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Southeast Missouri?

Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Southeast Missouri now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southeast Missouri right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.

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