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Hotels in Southeast Missouri

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Choose from 655 Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,014 reviews)
"Wonderful room and food offerings were extra thoughtful."

Reviewed on Jun 12, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,014 reviews)
"Evening drinks and meal were included. Breakfast was also included and very good"

Reviewed on Jun 11, 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
  • 1 hour drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,015 reviews)
"It was a great stay"

Reviewed on Jun 13, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (962 reviews)
"Overbooked my stay didn't have a room"

Reviewed on Jun 8, 2026

Candlewood Suites Cape Girardeau by IHG
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (597 reviews)
"The only downside to this location is that there is no option for breakfast on-site outside of what Starbucks offers. It's an excellent location to stay and the rooms are massive. We were there for a baseball tournament and the room did not disappoint."

Reviewed on Jun 12, 2026

The Riverview
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,008 reviews)
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."

Reviewed on Jun 8, 2026

Days Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
  • 4 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,010 reviews)
"Loved my stay here. Staff was so friendly and made me feel so welcomed!"

Reviewed on Jun 8, 2026

Drury Inn & Suites Hayti Caruthersville
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
  • 2 hours drive from Johnson's Shut-ins State Park
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,002 reviews)
"Not a good place to stay for more than 1 night. Small room. Breakfast was mostly pre-wrapped items. Not in a good location."

Reviewed on Jun 9, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
  • 2 hours drive from Johnson's Shut-ins State Park
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (75 reviews)
"The best accomodation I have had for years. The staff is easy to answer any request as long the request is reasonable. I also highly recommend the place for its superb cleanliness and cozy."

Reviewed on May 31, 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
  • 2 hours drive from Johnson's Shut-ins State Park
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
10/10 Exceptional! (2 reviews)
"Pet friendly. Family-friendly"

Reviewed on Apr 12, 2026

Lake Wappapello
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
  • 2 hours drive from Johnson's Shut-ins State Park
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (874 reviews)
"Good"

Reviewed on Jun 14, 2026

Hampton Inn Poplar Bluff
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
  • 2 hours drive from Johnson's Shut-ins State Park
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,004 reviews)
"This is our go-to motel when pass through Poplar Bluff. The staff is friendly, the property is clean and the rooms are spacious and clean."

Reviewed on Jun 12, 2026

Motel 6 Poplar Bluff, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 655 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southeast Missouri hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $64.

How many hotels are there in Southeast Missouri?

With over 655 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.

How to find cheap car rentals in Southeast Missouri?

Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.