Search for Cheap Deals onHotels in Southeast Missouri
Check Last Minute Southeast Missouri Hotel Deals
Choose from 662 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
"The room I had reserved was not available and no compensation for a down grade was offered."
Reviewed on Jul 13, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"It took three tries for the desk clerk to get me in a room that didn’t smell awful. First room smelled like sour milk the second like someone had smoked in the room that day. The third smelled nice like air freshener. Clerk was very helpful and got me in a clean room. No compensation was offered ..."
Reviewed on Jul 13, 2026
The Riverview
"When we arrived at our room, the floor felt sticky. My wife used a washcloth to go over the floor, it was black. She took a picture and showed the manager downstairs. He apologized and seemed to take a note of it, but when we returned to the room later, the same washcloth was still on the floor. ..."
Reviewed on Jul 13, 2026
Drury Inn & Suites Sikeston, MO
"Oh my! The food was delicious, the bed is completely comfy, the room was clean and very nice, the drinks were perfect, all of the crowd that was there were all happy and pleased, I just can’t express how nice our stay was. In fact we’re staying again in the same place! ❤️"
Reviewed on Jul 13, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"When they say tiny they mean tiny. The window view was amazing. In the middle of the woods all you see are trees. Well equipped for glamping. We enjoyed the campfire along with the peace and quiet. The Cozy and the dew drop in are close by and the food was worth the drive 🌟"
Reviewed on Jul 13, 2026
Pear Tree Inn Cape Girardeau West
"Rooms were very clean. Staff was excellent and informative. Parking by side entrance was excellent."
Reviewed on Jul 10, 2026
Drury Inn & Suites Hayti Caruthersville
"Convince to interstate"
Reviewed on Jul 13, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
"Stayed here for work. Breakfast was… okay, everything else was great."
Reviewed on Jul 13, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"The room had mold in the air conditioner and the refund wasn’t processed like it was supposed to be."
Reviewed on Jul 12, 2026
The Farmstead Hotel
"Staff was friendly and helpful, parking isn’t ideal due to the parking area being so small. No breakfast the room was cleanish, would rather have a downstairs room vs. an upstairs room."
Reviewed on Jul 13, 2026
Drury Inn & Suites Cape Girardeau
"Great location"
Reviewed on Jul 13, 2026
Honeysuckle Inn - Mountain View
"Very cute, friendly staff!"
Reviewed on Jul 13, 2026
Find cheap hotels in Southeast Missouri
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 662 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $63.
How many hotels are there in Southeast Missouri?
With over 662 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southeast Missouri
- Near An Attraction
- Hotel Theme
- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Southeast Missouri State University
- Hotels near Current River State Park
- Hotels near Century Casino Caruthersville
- Hotels near Big Spring
- Hotels near Echo Bluff State Park
- Hotels near Alley Spring & Mill
- Hotels near Taum Sauk Mountain State Park
- Hotels near Lake Wappapello
- Hotels near Rocky Falls
- Hotels near Akers Ferry
- Hotels near K Bridge Recreation Area
- Hotels near Sainte Genevieve Winery
- Hotels near Riverfront Bridge Park
- Hotels near St. Joe State Park
- Hotels near St. Francois State Park
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Winery Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Chesterfield Hotels
- Fenton Hotels
- Cape Girardeau Hotels
- Eminence Hotels
- Carbondale Hotels
- Ozarks Hotels
- Richmond Heights Hotels
- Van Buren Hotels
- Poplar Bluff Hotels
- Eureka Hotels
- Sikeston Hotels
- Farmington Hotels
- Wappapello Hotels
- Kirkwood Hotels
- Hardy Hotels
- East St. Louis Hotels
- Town and Country Hotels
- Arnold Hotels
- Brentwood Hotels
- Sullivan Hotels
