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Hotels in Southeast Missouri

Choose from 576 Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
  • 2 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (998 reviews)
"Good place for a no-frills stay. Reasonably prices, helpful stuff."

Reviewed on Jul 3, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (318 reviews)
"Easy check in"

Reviewed on Jul 4, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,008 reviews)
"Clean, large rooms and a comfortable bed. Arrived just as taco dinner & drinks were being served. Which was great after a long day of traveling."

Reviewed on Jul 6, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
  • 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,002 reviews)
"Friendly staff. Had everything we needed. No microwave. My husband said mattress wasn’t very comfortable but it didn’t bother me that much. No breakfast."

Reviewed on Jun 25, 2025

Motel 6 Poplar Bluff, MO
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
  • 3 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (767 reviews)
"Great location. Property well maintained."

Reviewed on Jul 5, 2025

Fairfield Inn & Suites by Marriott Poplar Bluff
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
"Didn’t have to think about anything. It was all right."

Reviewed on Jul 3, 2025

Best Western Plus Sikeston
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (371 reviews)
"Great stay!"

Reviewed on Jul 4, 2025

The Farmstead Hotel
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
  • 3 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (834 reviews)
Family vaca
"Great breakfast nice layover on our way to Florida"

Reviewed on Jun 24, 2025

Comfort Inn Festus - St Louis South
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
  • 5 hours drive from Mark Twain National Forest
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (578 reviews)
"Our first room was stained, dirty, and not acceptable. I asked for another room and was given a room that looked like it was in another hotel altogether. It was clean, big, comfortable. Perfect. The staff was super friendly and helpful."

Reviewed on Jul 4, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 4 hours drive from Mark Twain National Forest
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
"This is a great place to stay! Very clean, comfortable beds, free breakfast and supper. The people were very nice and I can’t recommend it highly enough!"

Reviewed on Jul 6, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,005 reviews)
"This hotel is very convenient to the highway and restaurants. The cost was very affordable and the front desk receptionist was extremely friendly. The rooms are spacious and comfortable. The only complaint was the free breakfast didn’t have any low-carb options (no meat and eggs). I would definitely ..."

Reviewed on Jun 30, 2025

Pear Tree Inn Cape Girardeau West
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,003 reviews)
"Great room with everything i needed!!!"

Reviewed on Jul 5, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 576 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southeast Missouri hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $64.

How many hotels are there in Southeast Missouri?

With over 576 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.

How to find cheap car rentals in Southeast Missouri?

Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.