Search for Cheap Deals onHotels in Southeast Missouri
Choose from 642 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
Rooms are very nice and clean, the staff was very friendly, many choices at breakfast, and parking is nice wherever your room is located. This is our go to hotel when we travel to Cape Girardeau.
Reviewed on Apr 5, 2026
The Riverview
Clean room. Nice view.
Reviewed on Apr 3, 2026
Drury Inn & Suites Sikeston, MO
It would be nice to have bacon sometime.
Reviewed on Apr 5, 2026
Drury Inn & Suites Cape Girardeau
Wonderful. I will definitely stay here again.
Reviewed on Apr 3, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Very helpful staff. We were able to use the CCS charger and charge to 100% both nights we stayed. I also enjoyed the gym.
Reviewed on Apr 4, 2026
Hampton Inn Sikeston
Was very clean & pet-friendly. Great place to stop on toad
Reviewed on Apr 4, 2026
Drury Inn & Suites Jackson MO
I’ve stayed at this hotel twice now while visiting family in the area. The property itself is very nice—clean, well‑maintained, and in a great location right off the interstate. The staff has also been friendly during both of my stays. However, both times my mom and I were placed in the exact same ...
Reviewed on Apr 4, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
Highly recommend. Beautiful, clean, up-to-date facility with excellent staff. Even the breakfast was good having not only cereal but eggs, sausage and biscuits as well. The only downside was there was no elevator so getting a lot of stuff up to the second floor was a bit tricky.
Reviewed on Apr 5, 2026
Motel 6 Poplar Bluff, MO
I stay here quite often in my travels. My room is almost always pretty clean - it is still a motel 6. Sheets and towels are always clean. I usually order food and just stay in my room once it’s dark out because I’m not sure about the area - it’s outside of town.
Reviewed on Apr 5, 2026
The Farmstead Hotel
Overall very good support team. I stay here on a regular basis.
Reviewed on Apr 5, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Nice place. spacious room, comfortable bed. Needs maintenance. most electrical sockets were worn out and inoperable. Breakfast could have been staffed better.
Reviewed on Apr 5, 2026
Pear Tree Inn Cape Girardeau West
Everything was as expected.
Reviewed on Apr 5, 2026
Find cheap hotels in Southeast Missouri
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 642 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $67.
How many hotels are there in Southeast Missouri?
With over 642 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southeast Missouri
- Near An Attraction
- Hotel Theme
- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Southeast Missouri State University
- Hotels near Elephant Rocks State Park
- Hotels near Century Casino Caruthersville
- Hotels near Lake Wappapello
- Hotels near Taum Sauk Mountain State Park
- Hotels near Current River State Park
- Hotels near Alley Spring & Mill
- Hotels near Echo Bluff State Park
- Hotels near Hawn State Park
- Hotels near Big Spring
- Hotels near Rocky Falls
- Hotels near K Bridge Recreation Area
- Hotels near Sainte Genevieve Winery
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Hotels near Akers Ferry
- Hotels near Riverfront Bridge Park
- Hotels near Bonne Terre Mine
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Winery Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Chesterfield Hotels
- Cape Girardeau Hotels
- Fenton Hotels
- Carbondale Hotels
- Arnold Hotels
- Eureka Hotels
- Poplar Bluff Hotels
- Sikeston Hotels
- Kirkwood Hotels
- Valley Park Hotels
- Richmond Heights Hotels
- East St. Louis Hotels
- Ozarks Hotels
- Farmington Hotels
- West Plains Hotels
- Pacific Hotels
- Eminence Hotels
- Frontenac Hotels
- Brentwood Hotels
- Ballwin Hotels
