Search for Cheap Deals onHotels in Southeast Missouri
Choose from 655 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
"Wonderful room and food offerings were extra thoughtful."
Reviewed on Jun 12, 2026
Drury Inn & Suites Sikeston, MO
"Evening drinks and meal were included. Breakfast was also included and very good"
Reviewed on Jun 11, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"It was a great stay"
Reviewed on Jun 13, 2026
Candlewood Suites Cape Girardeau by IHG
"Overbooked my stay didn't have a room"
Reviewed on Jun 8, 2026
The Riverview
"The only downside to this location is that there is no option for breakfast on-site outside of what Starbucks offers. It's an excellent location to stay and the rooms are massive. We were there for a baseball tournament and the room did not disappoint."
Reviewed on Jun 12, 2026
Days Inn and Suites by Wyndham Sikeston
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."
Reviewed on Jun 8, 2026
Drury Inn & Suites Hayti Caruthersville
"Loved my stay here. Staff was so friendly and made me feel so welcomed!"
Reviewed on Jun 8, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"Not a good place to stay for more than 1 night. Small room. Breakfast was mostly pre-wrapped items. Not in a good location."
Reviewed on Jun 9, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"The best accomodation I have had for years. The staff is easy to answer any request as long the request is reasonable. I also highly recommend the place for its superb cleanliness and cozy."
Reviewed on May 31, 2026
Lake Wappapello
"Pet friendly. Family-friendly"
Reviewed on Apr 12, 2026
Hampton Inn Poplar Bluff
"Good"
Reviewed on Jun 14, 2026
Motel 6 Poplar Bluff, MO
"This is our go-to motel when pass through Poplar Bluff. The staff is friendly, the property is clean and the rooms are spacious and clean."
Reviewed on Jun 12, 2026
Find cheap hotels in Southeast Missouri
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 655 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Southeast Missouri?
With over 655 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
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- Near An Airport
- Areas Of Southeast Missouri
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- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Ozark National Scenic Riverways
- Hotels near Southeast Missouri State University
- Hotels near Current River State Park
- Hotels near Century Casino Caruthersville
- Hotels near Alley Spring & Mill
- Hotels near Rocky Falls
- Hotels near Echo Bluff State Park
- Hotels near Akers Ferry
- Hotels near Sainte Genevieve Winery
- Hotels near Pickle Springs Natural Area
- Hotels near Lake Wappapello
- Hotels near Taum Sauk Mountain State Park
- Hotels near Big Spring
- Hotels near Hawn State Park
- Hotels near Washington State Park
- Hotels near Persimmon Ridge Winery
- Hotels near K Bridge Recreation Area
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
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- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
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- Chesterfield Hotels
- Wappapello Hotels
- Cape Girardeau Hotels
- Fenton Hotels
- Carbondale Hotels
- Eminence Hotels
- Eureka Hotels
- Poplar Bluff Hotels
- Ozarks Hotels
- Kirkwood Hotels
- Sikeston Hotels
- Farmington Hotels
- Richmond Heights Hotels
- Arnold Hotels
- East St. Louis Hotels
- Van Buren Hotels
- Brentwood Hotels
- Valley Park Hotels
- Town and Country Hotels
- West Plains Hotels
