Search for Cheap Deals onHotels in Sikeston
Choose from 319 Sikeston Hotel Deals
Drury Inn & Suites Sikeston, MO
"Wonderful staff. Pet friendly"
Reviewed on Jul 24, 2026
Best Western Plus Sikeston I-55
"Everything was well but the actual property was a little winding getting there (but i wasarriving at night) and there is not another business next to it, just a small lake, If you like that. Overall clean, nice and quiet. Nice breakfast room!"
Reviewed on Jul 25, 2026
Days Inn and Suites by Wyndham Sikeston
"Poor location -- far from restaurants or grocery. The parking lot was dirty (cigarette butts, broken asphalt, weeds untrimmed). Stair rubber treads are broken (a customer easy to trip and fall). Shower floor was dirty. The room had stain couch fabric, a lamp broken, and the TV reception was poor. ..."
Reviewed on Jul 24, 2026
Hampton Inn Sikeston
"Fast checking in and out. Very friendly staff and abundant complimentary breakfast. Spacious room and we liked having a walk in shower. There was plenty of green space to walk our small dog. The only complaint we had is that when we sat on the sofa, the cushion covers came off. They did not zip securely ..."
Reviewed on Jul 19, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
"Very clean and good breakfast"
Reviewed on Jul 25, 2026
Fairfield Inn & Suites by Marriott Sikeston
"Friendly staff, great breakfast, nice amenities"
Reviewed on Jul 19, 2026
Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
"N/a"
Reviewed on Jul 20, 2026
Country Yard Inn and Suite
"Building itself needs to be rebuilt but other than that it was clean"
Reviewed on Jul 24, 2026
Comfort Inn & Suites Sikeston I-55
"Wonderful location, clean and comfortable."
Reviewed on Jul 17, 2026
TownePlace Suites by Marriott Sikeston
"The breakfast staff was not good. The cream needed to be refilled. Oatmeal was not cooked. We had to wait for waffle machine to be fixed."
Reviewed on May 25, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
"Nice sized suite room with great amenities."
Reviewed on Jul 24, 2026
Find cheap hotels in Sikeston
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Sikeston hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Sikeston.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Sikeston’s 319 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $72. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Sikeston hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Sikeston. No matter your reason for visiting Sikeston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Sikeston hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Sikeston for as low as $72.
How many hotels are there in Sikeston?
With over 319 hotels in Sikeston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $72.
How to find cheap car rentals in Sikeston?
Finding a cheap car rental deal in Sikeston is as easy as scoring cheap hotels in Sikeston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Mississippi River
- Hotels near Shawnee National Forest
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Ohio River Valley
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near eDen Spa & Salon
- Hotels near Big Oak Tree State Park
- Hotels near Fort Defiance State Park
- Hotels near Mound City National Cemetery
- Hotels near The Heritage House
- Hotels near New Madrid Historical Museum
- Hotels near Hunter-Dawson State Historic Site
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Fort D Historic Site
- Hotels near River Ridge Winery
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels with Free Parking in Sikeston
- Family Hotels in Sikeston
- Pet-friendly Hotels in Sikeston
- Hotels with a Pool in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with Hot Tubs in Sikeston
- Casinos in Sikeston
- Luxury Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Apartment Hotel in Sikeston
- Historic Hotels in Sikeston
- Resorts & Hotels with Spas in Sikeston
- Hotels with smoking rooms in Sikeston
- Winery Hotels in Sikeston
- Adults Only Resorts & Hotels in Sikeston
- Romantic Hotels in Sikeston
- Cape Girardeau Hotels
- Ozarks Hotels
- Southern Illinois Hotels
- Southeastern United States Hotels
- Dexter Hotels
- Tiptonville Hotels
- Charleston Hotels
- Cairo Hotels
- Portageville Hotels
- Southeast Missouri Hotels
- Western Tennessee Hotels
- New Madrid Hotels
- Marston Hotels
- Western Kentucky Hotels
- The South Hotels
- Malden Hotels
- Central United States Hotels
- East Prairie Hotels
- Bloomfield Hotels
