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Hotels in Sikeston

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Choose from 264 Sikeston Hotel Deals

Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 5 min walk from City of Miner Convention Center
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,010 reviews)
"The area was clean and in a good area older room but had been renovated comfy bed and the a/c worked really well"

Reviewed on Jul 28, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 1 min walk from City of Miner Convention Center
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
"Enjoyed everything"

Reviewed on Jul 19, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 3 min walk from City of Miner Convention Center
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,008 reviews)
Nice hotel.
"Very nice hotel. Very friendly and clean. Breakfast was good. Will stay here again when back in region."

Reviewed on Jul 25, 2025

Pear Tree Inn Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 8 min drive from City of Miner Convention Center
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (368 reviews)
"It was great"

Reviewed on Jul 27, 2025

Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 min walk from City of Miner Convention Center
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."

Reviewed on Jul 26, 2025

Days Inn and Suites by Wyndham Sikeston
Fairfield by Marriott Inn & Suites Sikeston

Fairfield by Marriott Inn & Suites Sikeston

2.5 out of 5
1239 Commerce Drive, Sikeston, MO
  • 9 min drive from City of Miner Convention Center
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.8/10 Exceptional! (16 reviews)
"Absolutely excellent. Brand new hotel. Spotless. Staff were friendly and welcoming."

Reviewed on Jul 26, 2025

Fairfield by Marriott Inn & Suites Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 8 min drive from City of Miner Convention Center
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (419 reviews)
"Thank you to the courteous staff. Great night's rest after a really long day of travel"

Reviewed on Jul 27, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 5 min walk from City of Miner Convention Center
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (271 reviews)
"It was a very nice stay. The pool was clean and enjoying!"

Reviewed on Jul 18, 2025

Comfort Inn & Suites Sikeston I-55
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 5 min walk from City of Miner Convention Center
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (100 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
  • 1 hour drive from City of Miner Convention Center
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (365 reviews)
Great Economical Place to Stay
"It was a great place to stay. Even though a casino is attached to the hotel, it seemed like we were in a nice secluded area of Cape Girardeau. Everything was like new and very nice. Even had a Starbucks so we were able to get a refreshment before we got back on the road. The only down side was that ..."

Reviewed on Jul 29, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 1 hour drive from City of Miner Convention Center
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,016 reviews)
5 stars
"Hotel was extremely nice and comfortable. Unfortunately my family was unable to take advantage of the drinks and snacks in the lobby due to several youth volleyball teams also staying at the hotel. They took over the lobby and pool area and were so loud we couldn’t hear the hotel staff checking us ..."

Reviewed on Jul 24, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
  • 1 hour drive from City of Miner Convention Center
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,009 reviews)
Super Facility Near The Medical Center!
"I have stayed at this Hotel several times when I have had early morning reporting times at St. Francis Medical Center. Each time it has been great. Friendly staff quiet atmosphere and great rooms with comfortable furnishings."

Reviewed on Jul 29, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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