Search for Cheap Deals on
Hotels in Sikeston

Photo by Ryan Coleman

Choose from 261 Sikeston Hotel Deals

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 3 min walk from The Book Bug
The price is $98 per night from May 4 to May 5
$98
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
Comfortable nice stay!
"Great experience! Nice clean hotel with many travelers on site. Safe and well lit parking lot."

Reviewed on Apr 22, 2025

Pear Tree Inn Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 5 min walk from The Book Bug
The price is $114 per night from May 4 to May 5
$114
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
Great Place to Stay
"Great staff. Called you by your name and were super helpful. The room was very spacious and comfortable. The whole property was clean and well maintained. The breakfast was very tasty and ample with a nice attendant making sure everything was available."

Reviewed on Apr 22, 2025

Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 7 min walk from The Book Bug
The price is $103 per night from Apr 27 to Apr 28
$103
includes taxes & fees
Apr 27 - Apr 28
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
"Room had an unsanitary smell. Staff was willing to move me to another room but it had same animal or dirty smell"

Reviewed on Apr 20, 2025

Best Western Plus Sikeston
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 7 min drive from The Book Bug
The price is $143 per night from May 4 to May 5
$143
includes taxes & fees
May 4 - May 5
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (334 reviews)
"Very close to interstate"

Reviewed on Apr 22, 2025

Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 min walk from The Book Bug
The price is $92 per night from Apr 27 to Apr 28
$92
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"Nice and clean"

Reviewed on Apr 14, 2025

Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 7 min drive from The Book Bug
The price is $146 per night from Apr 27 to Apr 28
$146
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (402 reviews)
"Nothing"

Reviewed on Apr 11, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 8 min walk from The Book Bug
The price is $77 per night from Apr 27 to Apr 28
$77
includes taxes & fees
Apr 27 - Apr 28
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
6.8/10 (87 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 out of 5
100 Matthews Lane, Sikeston, MO
  • 2 min walk from The Book Bug
The price is $92 per night from Apr 26 to Apr 27
$92
includes taxes & fees
Apr 26 - Apr 27
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (650 reviews)
"Although the exterior is nothing special, thos hotel is very nicely and recently remodeled. Rooms are crisp and clean, staff are friendly."

Reviewed on Apr 21, 2025

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 2 min walk from The Book Bug
The price is $106 per night from May 4 to May 5
$106
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (249 reviews)
"It was okay, quiet and helpful."

Reviewed on Apr 5, 2025

Comfort Inn & Suites Sikeston I-55
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2 out of 5
2609 E Malone Ave, Sikeston, MO
  • 3 min walk from The Book Bug
The price is $69 per night from May 18 to May 19
$69
includes taxes & fees
May 18 - May 19
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions The Book Bug and Boot Heel Golf ...
6.6/10 (523 reviews)
"Amazing"

Reviewed on Apr 4, 2025

Super 8 by Wyndham Sikeston/Miner Area
TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
3 out of 5
1239 Commerce Drive, Sikeston, MO
  • 8 min drive from The Book Bug
The price is $145 per night from May 4 to May 5
$145
includes taxes & fees
May 4 - May 5
Stay at this 3-star hotel in Sikeston. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
TownePlace Suites by Marriott Sikeston
The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
  • 1 hour drive from The Book Bug
The price is $109 per night from Apr 27 to Apr 28
$109
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (233 reviews)
Twice visited and happy about it.
"Once again we enjoyed our stay. Very updated and spacious rooms. Comfortable beds and thick bathroom towels were enjoyable. Wish the showers had doors and rubber mats, but otherwise a lovely place to stay."

Reviewed on Apr 21, 2025

The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Sikeston

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Sikeston hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Sikeston.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Sikeston’s 261 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Sikeston hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Sikeston. No matter your reason for visiting Sikeston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Sikeston hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Sikeston for as low as $69.

How many hotels are there in Sikeston?

With over 261 hotels in Sikeston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.

How to find cheap car rentals in Sikeston?

Finding a cheap car rental deal in Sikeston is as easy as scoring cheap hotels in Sikeston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.