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Hotels in Sikeston

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Choose from 286 Sikeston Hotel Deals

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 20 min walk from Central Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (439 reviews)
Exactly what I’ve come to expect from a Hampton.

Reviewed on Dec 5, 2025

Hampton Inn Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 min drive from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Clean big room, great staff

Reviewed on Nov 30, 2025

Drury Inn & Suites Sikeston, MO
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 6 min drive from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (717 reviews)
Travel friendly accommodations at a good price. Facility was clean and functional as a halfway stopping point on the way home after Thanksgiving. Pet friendly option is a big plus for us. Recommended!

Reviewed on Nov 30, 2025

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 min drive from Central Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
Easy parking , quiet and comfortable bed , we’ll stop again on our way back

Reviewed on Dec 7, 2025

Best Western Plus Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 7 min drive from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Very nice room with a separate room for relaxing and watching TV. Generous breakfast bar and very nice staff. I plan on staying again next month.

Reviewed on Nov 30, 2025

Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue Sikeston MO
  • 6 min drive from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
This is our go to when we visit relatives

Reviewed on Dec 5, 2025

Pear Tree Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive Sikeston MO
  • 23 min walk from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.2/10 Wonderful! (37 reviews)
Extremely clean, and it looks to be updated in the more recent years. Large workout room that looks into the pool. Hot and tasty breakfast.

Reviewed on Nov 16, 2025

Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 19 min walk from Central Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (443 reviews)
Staff was great. Hotel was clean. Great sleep.

Reviewed on Dec 5, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 6 min drive from Central Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.6/10 (561 reviews)
ALL GREAT

Reviewed on Nov 21, 2025

Super 8 by Wyndham Sikeston/Miner Area
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 1 hour drive from Central Park
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,000 reviews)
Great

Reviewed on Dec 1, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 1 hour drive from Central Park
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (464 reviews)
Helpful staff, clean room.

Reviewed on Nov 26, 2025

The Riverview
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 1 hour drive from Central Park
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (659 reviews)
Nice room and pool and fitness room. Bed a little hard and lumpy, sink drain slow, shower water pressure low, musty smell in bathroom (curtain?), pool opened too late for my aerobic exercises (8am). (Prefer bacon to sausage)

Reviewed on Dec 1, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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