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Hotels in Sikeston

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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,008 reviews)
"Our stay was amazing! The breakfast and kickback were really good. The only complaint was the AC in our suite only really cooled the bedroom."

Reviewed on Jun 8, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,007 reviews)
"Lobby reeked like pot and cigarettes, room was not the cleanest and smelled like wet dog, water only got lukewarm, and milk for breakfast was days expired. Pics on Expedia definitely don’t look like the room we had."

Reviewed on Jun 8, 2026

Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (574 reviews)
"The doughnuts and fry potatoes for breakfast were delicious"

Reviewed on Jun 2, 2026

Hampton Inn Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 6 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (642 reviews)
"Had a good stay. The room was nice."

Reviewed on Jun 3, 2026

Super 8 by Wyndham Sikeston/Miner Area
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,007 reviews)
"The breakfast was really good, as was the coffee. It’s rarely good in hotels, but this coffee was very good. The staff was quite friendly. Thanks"

Reviewed on Jun 9, 2026

Best Western Plus Sikeston I-55
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (787 reviews)
"We had been in different hotels for 8 previous nights, so we were tired of waffles and bread for breakfast. But the room was comfortable although I think the whole hotel needs deep carpet cleaning. It smelled slightly like an ash tray. The staff was very friendly and helpful."

Reviewed on Jun 3, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 29 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (84 reviews)
"Great stay, kind staff, very clean property."

Reviewed on May 30, 2026

Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 26 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (467 reviews)
"The room was clean the bed was comfortable. The breakfast was great . The hotel staff was great."

Reviewed on Jun 7, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.2/10 Wonderful! (18 reviews)
"The breakfast staff was not good. The cream needed to be refilled. Oatmeal was not cooked. We had to wait for waffle machine to be fixed."

Reviewed on May 25, 2026

TownePlace Suites by Marriott Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,007 reviews)
"Very clean, helpful staff"

Reviewed on Jun 2, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (960 reviews)
"Overbooked my stay didn't have a room"

Reviewed on Jun 8, 2026

Candlewood Suites Cape Girardeau by IHG
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (593 reviews)
"Staff was friendly. Rooms were very clean and comfortable. The Casino also paid us pretty well!!"

Reviewed on Jun 9, 2026

The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Sikeston

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