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Choose from 58 New Madrid Hotel Deals
Hampton Inn Sikeston
"Great hotel, clean spacious room, good breakfast choice"
Reviewed on Oct 22, 2026
Reelfoot Lake Inn
Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
"We had a nice overnight stay here. The sleeper/sofa was not comfortable, but very few are. It was a good selection of foods for the breakfast. We especially enjoyed the coffee machine that freshly grinds the coffee beans and brews it immediately. We also liked the style of the luggage carts. They ..."
Reviewed on Oct 25, 2026
Super 8 By Wyndham Marston
"It was good for an overnight stay - inexpensive, in a pretty spot - we enjoyed going for a walk."
Reviewed on Oct 24, 2026
New Orleans Inn Portageville
"This was the worst experience ever. Booked two rooms to attend a wedding and we only stayed for 45 minutes before we left to go to another motel. First glance there was trash piled in front of the motel. Door keys would not unlock. Finally got my one key to work but my daughters key would not work ..."
Reviewed on Oct 18, 2026
TownePlace Suites by Marriott Sikeston
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
Reviewed on Oct 28, 2026
Travel Inn Marston I-55 by Hotel O
"Great no problems with the room"
Reviewed on Oct 25, 2026
Find cheap hotels in New Madrid
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in New Madrid.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of New Madrid’s 58 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $58. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great New Madrid hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in New Madrid. No matter your reason for visiting New Madrid, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About New Madrid hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in New Madrid for as low as $58.
How many hotels are there in New Madrid?
With over 58 hotels in New Madrid, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $58.
How to find cheap car rentals in New Madrid?
Finding a cheap car rental deal in New Madrid is as easy as scoring cheap hotels in New Madrid. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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