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Sikeston

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Sikeston Flights as Low as $38

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$38 Roundtrip, found 2 hours ago
$38
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $38 found 2 hours ago
Frontier Airlines
Wed, Oct 28 - Mon, Nov 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$43 Roundtrip, found 1 hour ago
$43
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Nov 2, priced at $43 found 1 hour ago
Frontier Airlines
Wed, Dec 2 - Fri, Dec 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$48 Roundtrip, found 2 hours ago
$48
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Dec 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Dec 4, priced at $48 found 2 hours ago
Frontier Airlines
Fri, Oct 2 - Fri, Oct 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$67 Roundtrip, found 2 hours ago
$67
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Fri, Oct 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 16, priced at $67 found 2 hours ago
Frontier Airlines
Fri, Dec 4 - Fri, Dec 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$69 Roundtrip, found 2 days ago
$69
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Dec 4 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Dec 4, priced at $69 found 2 days ago
Delta
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$79 Roundtrip, found 2 hours ago
$79
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $79 found 2 hours ago
Delta
Wed, Oct 28 - Mon, Nov 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 1 hour ago
$84
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Nov 2, priced at $84 found 1 hour ago
Frontier Airlines
Mon, Sep 28 - Wed, Sep 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 4 days ago
$88
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Sep 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 30, priced at $88 found 4 days ago
Frontier Airlines
Sat, Oct 31 - Sat, Nov 7
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$90 Roundtrip, found 2 hours ago
$90
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, Oct 31 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Nov 7, priced at $90 found 2 hours ago
Delta
Sat, Dec 5 - Sat, Dec 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$112 Roundtrip, found 1 hour ago
$112
Roundtrip
found 1 hour ago
Select Delta flight, departing Sat, Dec 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Dec 5, priced at $112 found 1 hour ago
Southwest Airlines
Sat, Dec 5 - Sat, Dec 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 1 hour ago
$117
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Sat, Dec 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Dec 5, priced at $117 found 1 hour ago
American Airlines
Sat, Dec 5 - Sat, Dec 5
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 1 hour ago
$159
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Sat, Dec 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Dec 5, priced at $159 found 1 hour ago
United
Sat, Oct 31 - Sat, Nov 7
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, found 2 hours ago
$180
Roundtrip
found 2 hours ago
Select United flight, departing Sat, Oct 31 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Nov 7, priced at $180 found 2 hours ago
Frontier Airlines
Sat, Oct 31 - Sat, Nov 14
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 2 hours ago
$193
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, Oct 31 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Sat, Nov 14, priced at $193 found 2 hours ago
Southwest Airlines
Fri, Oct 30 - Mon, Nov 16
DAL
Love Field
STL
Lambert-St. Louis Intl.
$273 Roundtrip, found 2 hours ago
$273
Roundtrip
found 2 hours ago
Select Southwest Airlines flight, departing Fri, Oct 30 from Love Field to Lambert-St. Louis Intl., returning Mon, Nov 16, priced at $273 found 2 hours ago
Alaska Airlines
Thu, Nov 19 - Mon, Dec 7
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$495 Roundtrip, found 1 hour ago
$495
Roundtrip
found 1 hour ago
Select Alaska Airlines flight, departing Thu, Nov 19 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Mon, Dec 7, priced at $495 found 1 hour ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $38, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $38 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$38

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
"This was my second time staying at Drury hotel. I will most definitely book another stay."

Reviewed on Sep 6, 2026

Get rates
Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,009 reviews)
"Bathroom was very dirty. Mattress should have been replaced long ago. There was a bullet hole in the outer layer of glass window. Windows very dirty. Breakfast was good."

Reviewed on Sep 7, 2026

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Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"The sheets in the bed had a blood stain on it. I told the lady at the front desk and she came and changed the sheets for me. The stopper in the sink for the bathroom was not functional. The couch in the office area had stains on it. The refrigerator freezer needed to be defrosted. It had a lot of ..."

Reviewed on Sep 9, 2026

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Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (621 reviews)
"Really quiet place close to good restaurants and stores."

Reviewed on Sep 8, 2026

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Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
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Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
7/10 Good! (673 reviews)
"We had no problem checking in. The room was nice and clean. The staff were courteous and helpful. Parking was acceptable. Close to our room. No complaints."

Reviewed on Sep 8, 2026

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Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (820 reviews)
"For a older hotel. It was pleasant. Very good staff"

Reviewed on Sep 4, 2026

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Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
Get rates
Fairfield Inn & Suites by Marriott Sikeston
See all 318 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.