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Sikeston

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Sikeston Flights as Low as $58

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Jun 2 - Tue, Jun 9
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 1 day ago
$58
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Jun 9, priced at $58 found 1 day ago
Frontier Airlines
Sat, May 30 - Wed, Jun 10
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$78 Roundtrip, found 1 day ago
$78
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 30 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $78 found 1 day ago
Frontier Airlines
Thu, May 28 - Sat, May 30
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$99 Roundtrip, found 2 days ago
$99
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, May 28 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $99 found 2 days ago
Frontier Airlines
Sat, Jun 6 - Sat, Jun 13
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$100 Roundtrip, found 1 day ago
$100
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jun 6 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sat, Jun 13, priced at $100 found 1 day ago
Frontier Airlines
Tue, Aug 11 - Tue, Aug 18
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 5 days ago
$190
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Tue, Aug 11 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Aug 18, priced at $190 found 5 days ago
Delta
Tue, Jun 9 - Wed, Jun 10
DAL
Love Field
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jun 9 from Love Field to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $195 found 1 day ago
Delta
Tue, Jun 9 - Wed, Jun 10
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jun 9 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $195 found 1 day ago
Frontier Airlines
Mon, Jul 20 - Wed, Jul 22
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 1 day ago
$210
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Jul 20 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Wed, Jul 22, priced at $210 found 1 day ago
American Airlines
Tue, Jun 9 - Wed, Jun 10
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$219 Roundtrip, found 1 day ago
$219
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jun 9 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $219 found 1 day ago
United
Tue, Jun 9 - Wed, Jun 10
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$232 Roundtrip, found 1 day ago
$232
Roundtrip
found 1 day ago
Select United flight, departing Tue, Jun 9 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $232 found 1 day ago
Delta
Tue, May 12 - Tue, May 19
SRQ
Sarasota-Bradenton Intl.
STL
Lambert-St. Louis Intl.
$236 Roundtrip, found 1 day ago
$236
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, May 12 from Sarasota-Bradenton Intl. to Lambert-St. Louis Intl., returning Tue, May 19, priced at $236 found 1 day ago
Contour Airlines
Wed, Apr 29 - Wed, May 6
DFW
Dallas-Fort Worth Intl.
CGI
Cape Girardeau Municipal
$275 Roundtrip, found 1 day ago
$275
Roundtrip
found 1 day ago
Select Contour Airlines flight, departing Wed, Apr 29 from Dallas-Fort Worth Intl. to Cape Girardeau Municipal, returning Wed, May 6, priced at $275 found 1 day ago
American Airlines
Tue, Jul 14 - Wed, Jul 15
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$480 Roundtrip, found 1 day ago
$480
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $480 found 1 day ago
United
Thu, Jul 9 - Tue, Jul 14
BWI
Baltimore Washington Intl. Thurgood Marshall
CGI
Cape Girardeau Municipal
$508 Roundtrip, found 3 days ago
$508
Roundtrip
found 3 days ago
Select United flight, departing Thu, Jul 9 from Baltimore Washington Intl. Thurgood Marshall to Cape Girardeau Municipal, returning Tue, Jul 14, priced at $508 found 3 days ago
United
Mon, Jun 8 - Sat, Jun 20
BWI
Baltimore Washington Intl. Thurgood Marshall
PAH
Barkley Regional
$514 Roundtrip, found 6 days ago
$514
Roundtrip
found 6 days ago
Select United flight, departing Mon, Jun 8 from Baltimore Washington Intl. Thurgood Marshall to Barkley Regional, returning Sat, Jun 20, priced at $514 found 6 days ago
United
Sat, Jul 11 - Mon, Jul 13
SRQ
Sarasota-Bradenton Intl.
CGI
Cape Girardeau Municipal
$588 Roundtrip, found 1 day ago
$588
Roundtrip
found 1 day ago
Select United flight, departing Sat, Jul 11 from Sarasota-Bradenton Intl. to Cape Girardeau Municipal, returning Mon, Jul 13, priced at $588 found 1 day ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $58, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $58 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$70

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,004 reviews)
👍

Reviewed on Apr 19, 2026

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Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (545 reviews)
Property was pet friendly. They have nice dog park in the back of the building.

Reviewed on Apr 24, 2026

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Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
I stayed in Room 214. The room was clean, but there were some furniture and appliance problems. The smoke detector in the off room with the sofa was disconnected from the ceiling and hanging by its wires. The caulking around the sink in the bathroom was coming a loose. The hair drier was melted at ...

Reviewed on Apr 21, 2026

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Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Bathroom had pee stains around the toilet. On their add they use a picture of a large beautiful room where you check in. Not This motel is old and run down.

Reviewed on Apr 22, 2026

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Best Western Plus Sikeston I-55
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (613 reviews)
Cheap room not bad for the price. Would stay again if I was in the area.

Reviewed on Apr 19, 2026

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Super 8 by Wyndham Sikeston/Miner Area
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (72 reviews)
The breakfast was good, the service was good, and the staff was very friendly

Reviewed on Apr 12, 2026

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Fairfield Inn & Suites by Marriott Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (769 reviews)
Check in was friendly and efficient. The room was very nice, but the bed was so hard and uncomfortable we weren’t able to sleep well.

Reviewed on Apr 24, 2026

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Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (460 reviews)
Our room was clean. The pool was nice. Breakfast was acceptable. The price a bit steep, but less because we got it thru hotels.com.

Reviewed on Apr 18, 2026

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Holiday Inn Express & Suites Sikeston Southwest by IHG
See all 299 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.