Search for Cheap Deals onHotels in East Prairie
Choose from 86 East Prairie Hotel Deals
Drury Inn & Suites Sikeston, MO
We will definitely be back! We travel from Wisconsin to Texas at least 2 times a year to visit family and we like to break our trip up with an overnight stay. This Drury Inn in Siikeston, Missouri will be our home away from
Reviewed on Mar 28, 2026
Hampton Inn Sikeston
Lovely facilities. Friendly staff.
Reviewed on Mar 27, 2026
Best Western Plus Sikeston I-55
Room was clean, breakfast was good, staff was friendly
Reviewed on Mar 27, 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)
Reviewed on Mar 22, 2026
Days Inn and Suites by Wyndham Sikeston
There were roaches crawling up the wall when we went in and the outside was horrible! Looked like a vacant building!! I want my money back
Reviewed on Mar 24, 2026
Sleep Inn at Discovery Park of America
Good free parking!!
Reviewed on Mar 19, 2026
Holiday Inn Express & Suites Union City by IHG
Everything was great
Reviewed on Mar 11, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Clean rooms, friendly staff and convenient location.
Reviewed on Mar 23, 2026
Fairfield Inn & Suites by Marriott Sikeston
Perfect
Reviewed on Mar 27, 2026
Super 8 by Wyndham Sikeston/Miner Area
Room was supposed to be non smoking room but smelled of smoke.
Reviewed on Mar 16, 2026
Reelfoot Lake Inn
The view of the lake is beautiful. It's right across the road. The manager and staff were very kind and set me up in the kind of room I requested. It had a microwave, refrigerator and coffee pot with the coffee. The bed was very comfortable and the air worked great. I would stay there again.
Reviewed on Mar 27, 2026
Country Yard Inn and Suite
Yes, parking seemed just like a regular parkikg area. Well lit i believe. The room was able to be kept sufficiently cool.
Reviewed on Mar 25, 2026
Find cheap hotels in East Prairie
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your East Prairie hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in East Prairie.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of East Prairie’s 86 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $71. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great East Prairie hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in East Prairie. No matter your reason for visiting East Prairie, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About East Prairie hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in East Prairie for as low as $71.
How many hotels are there in East Prairie?
With over 86 hotels in East Prairie, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $71.
How to find cheap car rentals in East Prairie?
Finding a cheap car rental deal in East Prairie is as easy as scoring cheap hotels in East Prairie. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotels near Big Oak Tree State Park
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Discovery Park of America
- Hotels near Reelfoot Lake State Park
- Hotels near Ohio River Valley
- Hotels near Columbus-Belmont State Park
- Hotels near Central Park
- Hotels near Sikeston Depot Museum
- Hotels near Campbell's Point
- Hotels near Fort Defiance State Park
- Hotels near Union City Masquerade Theatre
- Hotels near Marston Community Center
- Hotels near River Ridge Winery
- Hotels near Graham Park
- Hotels near New Madrid Historical Museum
- Hotels near Hunter-Dawson State Historic Site
- Sikeston Hotels
- Southern Illinois Hotels
- Southeastern United States Hotels
- Union City Hotels
- Tiptonville Hotels
- Hornbeak Hotels
- Cairo Hotels
- Marston Hotels
- Charleston Hotels
- Southeast Missouri Hotels
- Portageville Hotels
- Fulton Hotels
- Western Tennessee Hotels
- New Madrid Hotels
- Western Kentucky Hotels
- Samburg Hotels
- The South Hotels
- Central United States Hotels
- Clinton Hotels
- Bardwell Hotels
