Search for Cheap Deals on
Hotels in East Prairie

Choose from 86 East Prairie Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
Great

Reviewed on Feb 4, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (474 reviews)
Great place for an overnight stay. I will be back!

Reviewed on Jan 26, 2026

Hampton Inn Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
  • 38 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Discovery Park of America and ...
9/10 Wonderful! (340 reviews)
The room was clean as usual! The staff always go above and beyond!

Reviewed on Jan 29, 2026

Sleep Inn at Discovery Park of America
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (735 reviews)
Room was clean ! Ice and snow made parking lot rough!! Enjoyed my days for work !

Reviewed on Feb 5, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
Yes

Reviewed on Feb 7, 2026

Best Western Plus Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 46 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Clean comfy stay ! Thanks

Reviewed on Feb 2, 2026

Days Inn and Suites by Wyndham Sikeston
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 out of 5
1221 W Reelfoot Ave Union City TN
  • 41 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (379 reviews)
Room was clean

Reviewed on Feb 1, 2026

Hospitality House Union City I 69 / US 51
Reelfoot Lake Inn

Reelfoot Lake Inn

2 out of 5
1520 State Route 21 East Tiptonville TN
  • 46 min drive from Big Oak Tree State Park
Stay at this motel in Tiptonville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
7/10 Good! (465 reviews)
Nice in clean room

Reviewed on Jan 19, 2026

Reelfoot Lake Inn
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.6/10 (592 reviews)
Greatness

Reviewed on Feb 3, 2026

Super 8 by Wyndham Sikeston/Miner Area
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.2/10 Wonderful! (56 reviews)
Clean rooms great staff

Reviewed on Feb 1, 2026

Fairfield Inn & Suites by Marriott Sikeston
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
  • 44 min drive from Big Oak Tree State Park
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (738 reviews)
Fairly clean.

Reviewed on Feb 2, 2026

New Orleans Inn Portageville
Hampton Inn Union City

Hampton Inn Union City

2.5 out of 5
2121 W REELFOOT AVE Union City TN
  • 43 min drive from Big Oak Tree State Park
Stay at this hotel in Union City. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.4/10 Exceptional! (170 reviews)
Spotless , friendly staff.

Reviewed on Feb 1, 2026

Hampton Inn Union City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in East Prairie

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your East Prairie hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in East Prairie.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of East Prairie’s 86 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great East Prairie hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in East Prairie. No matter your reason for visiting East Prairie, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About East Prairie hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in East Prairie for as low as $67.

How many hotels are there in East Prairie?

With over 86 hotels in East Prairie, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in East Prairie?

Finding a cheap car rental deal in East Prairie is as easy as scoring cheap hotels in East Prairie. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.