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Featured Otay Mesa Family Hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (1,406 reviews)
"Todo bien"
Reviewed on Jun 2, 2025
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7/10 Good! (1,000 reviews)
"I don’t see any"
Reviewed on May 23, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Suites San Diego Otay Mesa
2351 Otay Center Dr, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Otay Mesa
- Historic Hotels in Otay Mesa
- Hotels with Free Parking in Otay Mesa
- Beach Hotels in Otay Mesa
- Winery Hotels in Otay Mesa
- Hotels with Hot Tubs in Otay Mesa
- Casinos in Otay Mesa
- Resorts & Hotels with Spas in Otay Mesa
- Hotels with smoking rooms in Otay Mesa
- Luxury Hotels in Otay Mesa
Top Points of Interests in Otay Mesa
- Hotels near Cross Border Xpress
- Hotels near San Diego Zoo
- Hotels near San Diego Convention Center
- Hotels near Mission Bay
- Hotels near San Ysidro Border Crossing
- Hotels near Mission Beach
- Hotels near Balboa Park
- Hotels near Petco Park
- Hotels near Hotel Circle
- Hotels near San Diego State University
- Hotels near Naval Base San Diego
- Hotels near Marine Corps Recruit Depot
- Hotels near Port of San Diego
- Hotels near USS Midway Museum
- Hotels near Coronado Beach
- Hotels near Seaport Village
- Hotels near University of San Diego
- Hotels near Naval Base Coronado
- Hotels near Hotel del Coronado
- Hotels near Mission Beach Boardwalk
Cities near Otay Mesa
- San Diego Hotels (15.34 mi)
- Chula Vista Hotels (8.51 mi)
- Coronado Hotels (14.99 mi)
- Playas de Rosarito Hotels (21.71 mi)
- Rosarito Hotels (14.31 mi)
- El Cajon Hotels (16.26 mi)
- Coronado Island Hotels (16.04 mi)
- Southern California Hotels (91.04 mi)
- National City Hotels (10.98 mi)
- Imperial Beach Hotels (8.3 mi)
- La Mesa Hotels (14.67 mi)
- San Ysidro Hotels (4.08 mi)
- Santee Hotels (19.26 mi)
- Alpine Hotels (22.51 mi)
- Tecate Hotels (19.72 mi)
- Spring Valley Hotels (12.88 mi)
- Lakeside Hotels (20.78 mi)
- Bonita Hotels (7.71 mi)
- San Diego Coast Hotels (24.31 mi)
- Jamul Hotels (12.26 mi)
Car Rentals Near Otay Mesa
- Car rentals in San Diego
- Car rentals in Chula Vista
- Car rentals in Coronado
- Car rentals in Playas de Rosarito
- Car rentals in Rosarito
- Car rentals in El Cajon
- Car rentals in Coronado Island
- Car rentals in Southern California
- Car rentals in National City
- Car rentals in Imperial Beach
- Car rentals in La Mesa
- Car rentals in San Ysidro
- Car rentals in Santee
- Car rentals in Alpine
- Car rentals in Tecate
- Car rentals in Spring Valley
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Otay Mesa
- Manchester Grand Hyatt San Diego
- Kings Inn San Diego
- The Dana on Mission Bay
- Marriott Marquis San Diego Marina
- San Diego Mission Bay Resort
- Wyndham San Diego Bayside
- Wyndham Garden San Diego Near SeaWorld
- Handlery Hotel
- Loews Coronado Bay Resort
- Best Western Seven Seas
- Hilton San Diego Bayfront
- Days Inn by Wyndham San Diego Hotel Circle
- Sheraton San Diego Resort
- Hotel del Coronado, Curio Collection by Hilton