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Hotels in Santee

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Choose from 9789 Santee Hotel Deals

Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
  • 18 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9/10 Wonderful! (3,152 reviews)
Great stay and location!

Reviewed on Dec 3, 2025

Bay Club Hotel & Marina
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
  • 11 min drive from Mission Trails Regional Park
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
9/10 Wonderful! (2,957 reviews)
All was great

Reviewed on Dec 8, 2025

Legacy Resort Hotel & Spa
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
  • 17 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (706 reviews)
Good place when you are on a budget.

Reviewed on Dec 2, 2025

The DEXTRO Little Italy, BW Premier Collection
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
  • 19 min drive from Mission Trails Regional Park
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
8.8/10 Excellent! (3,127 reviews)
Nice rooms central location. Great stay!!

Reviewed on Dec 2, 2025

Hard Rock Hotel San Diego
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 out of 5
2151 Hotel Circle South San Diego CA
  • 11 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,275 reviews)
Spacious and clean rooms, helpful staff

Reviewed on Dec 2, 2025

Hampton Inn San Diego/Mission Valley
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St San Diego CA
  • 12 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Port of ...
9/10 Wonderful! (393 reviews)
It was amazing, the tv did not work properly but the front desk were quick to move me to a room directly across which made it easier since we had already unpacked, but the stay was awesome and the complimentary breakfast was fire, definitely will stay again, thank you

Reviewed on Dec 9, 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 out of 5
800 Bay Marina Dr National City CA
  • 27 min drive from Mission Trails Regional Park
Book a stay at this golf hotel in National City. Enjoy free WiFi, free parking, and a golf course. Our guests praise the pool and the restaurant in our reviews. ...
9.2/10 Wonderful! (3,476 reviews)
Great location off highway. Beautiful property and the lobby was beautifully festive for Christmas holiday season.

Reviewed on Dec 4, 2025

Best Western Plus Marina Gateway Hotel
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
  • 16 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,157 reviews)
Great stay!

Reviewed on Dec 3, 2025

Sheraton San Diego Resort
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
  • 11 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,312 reviews)
Very hip place to stay with lobby bars always hopping. Rooms were cute and nice neighborhood.

Reviewed on Dec 1, 2025

Lafayette Hotel & Club
Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel

4 out of 5
1433 Camino Del Rio S San Diego CA
  • 10 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,643 reviews)
Great hotel! Very centric.

Reviewed on Dec 2, 2025

Sheraton Mission Valley San Diego Hotel
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
  • 10 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,238 reviews)
I’ve stayed at many Hilton properties, and as a Hilton Honors member, I tend to be a bit more critical than most. The staff at this location was amazing. Management has clearly done an outstanding job training their team. Amina assisted us at check-in and did a fantastic job straightening out our ...

Reviewed on Dec 8, 2025

Hilton San Diego Mission Valley
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr La Jolla CA
  • 10 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.4/10 Very Good! (2,156 reviews)
My room was clean but felt a little outdated. It was comfortable however. What stood out to me most was the staff members I dealt with. Without exception, everyone was very friendly, professional, and helpful. I did not get any names but I’ll describe the circumstances in the hopes they can be identified ...

Reviewed on Dec 1, 2025

San Diego Marriott La Jolla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 9,789 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $113. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $113.

How many hotels are there in Santee?

With over 9,789 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $113.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.