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Hotels in Santee

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Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
  • 15 min drive from Santee Lakes
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (2,458 reviews)
Wonderful place to stay. There were little things here and there (like a tear in our couch) that made me take a 2nd look. But besides that, it was a great trip. We will visit again.

Reviewed on Mar 17, 2026

Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
  • 17 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,300 reviews)
The receptionist was very helpful

Reviewed on Mar 16, 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
  • 25 min drive from Santee Lakes
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (3,432 reviews)
They charged $100 more than it was showing on hotels.com. Said it is mandatory resort fees. We were given a handicap room which was fine until showering. The floor design completely floods the entire bathroom floor. Front desk staff were rude when we asked about the extra charges. We will not stay ...

Reviewed on Mar 17, 2026

Hard Rock Hotel San Diego
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
  • 17 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (2,556 reviews)
This hotel fits our need for a clean, comfortable and convenient stop when we are in San Diego. The staff is accommodating and our room was pleasant and roomy. We have stayed here previously and this was by far our best experience with a large accessible room. We unloaded the car directly into our ...

Reviewed on Mar 17, 2026

Days Inn by Wyndham San Diego Hotel Circle
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
  • 17 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (2,341 reviews)
Nice hotel

Reviewed on Mar 16, 2026

Handlery Hotel
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
  • 23 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9/10 Wonderful! (1,204 reviews)
Expensive parking!

Reviewed on Mar 16, 2026

The DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
  • 24 min drive from Santee Lakes
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,822 reviews)
Appreciated the fitness room! Very close to convention center, super friendly staff.

Reviewed on Mar 17, 2026

The Sofia Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
  • 25 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
9/10 Wonderful! (2,900 reviews)
Perfect service

Reviewed on Mar 13, 2026

Manchester Grand Hyatt San Diego
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

4 out of 5
11915 El Camino Real San Diego CA
  • 14 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
8.6/10 Excellent! (2,178 reviews)
Very nice

Reviewed on Mar 17, 2026

DoubleTree by Hilton San Diego - Del Mar
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
  • 23 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (6,058 reviews)
Clean

Reviewed on Mar 17, 2026

Wyndham San Diego Bayside
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
  • 22 min drive from Santee Lakes
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.4/10 Very Good! (3,379 reviews)
Our room was clean and spacious. The bathroom was also clean and spacious and everything worked very well. I was in the hallway and asked staff for extra towels and she gladly provided what we needed. I would definitely stay here again!

Reviewed on Mar 17, 2026

Sheraton San Diego Resort
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
  • 16 min drive from Santee Lakes
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
9/10 Wonderful! (4,166 reviews)
Great location and friendly staff

Reviewed on Mar 16, 2026

The Dana on Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $87. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

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Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santee?

With over 9,769 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.

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Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.