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Kid-Friendly Hotels in Cape Girardeau

The Bar - this was one location Gone Girl was filmed at!

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Featured Cape Girardeau Family Hotels

Drury Inn & Suites Cape Girardeau

3303 Campster Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

Fully refundable

Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...

Hampton Inn Cape Girardeau I 55 East

207 S Mt Auburn Rd Cape Girardeau MO

Fully refundableReserve now, pay when you stay

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

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Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

Fully refundable

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...

Quality Inn

2011 North Kingshighway Cape Girardeau MO

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Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

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Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

See all 171 properties in Cape Girardeau

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels with Pools in Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...

9.4/10 Exceptional! (1,007 reviews)

Clean room and staff was very friendly.

Reviewed on Nov 29, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO

Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (1,003 reviews)

Very friendly people, clean rooms, comfortable bed, great breakfast,

Reviewed on Nov 27, 2025