Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Cape Girardeau Vacations

Pack those stellar shades. We have Cape Girardeau vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Cape Girardeau – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Cape Girardeau vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Cape Girardeau

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Cape Girardeau vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Cape Girardeau well.

Top Hotel Deals

See all 30 Properties in Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau
    2.5 out of 5.0
     
     

    Located in the heart of Cape Girardeau, this hotel is 2.2 mi (3.6 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State ...

    Pear Tree Inn Cape Girardeau Near the Medical Center$70

    Pear Tree Inn Cape Girardeau Near the Medical Center$70
    Drury Plaza Hotel Cape Girardeau Conference Center

    Drury Plaza Hotel Cape Girardeau Conference Center

    3351 Percy Drive, Cape Girardeau
      3.0 out of 5.0
       
       

      Situated in Cape Girardeau, this hotel is 2.2 mi (3.5 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University ...

      Drury Plaza Hotel Cape Girardeau Conference Center$125

      Drury Plaza Hotel Cape Girardeau Conference Center$125
      Pear Tree Inn Cape Girardeau West

      Pear Tree Inn Cape Girardeau West

      103 Cape West Pkwy, Cape Girardeau
        2.5 out of 5.0
         
         

        Located in the heart of Cape Girardeau, this hotel is 2.8 mi (4.4 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State ...

        Pear Tree Inn Cape Girardeau West$70

        Pear Tree Inn Cape Girardeau West$70
        Auburn Place Hotel And Suites

        Auburn Place Hotel And Suites

        3265 William St, Cape Girardeau
          2.5 out of 5.0
           
           

          Situated in Cape Girardeau, this hotel is 2.4 mi (3.8 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University ...

          Auburn Place Hotel And Suites$79

          Auburn Place Hotel And Suites$79
          Hampton Inn Cape Girardeau I 55 East

          Hampton Inn Cape Girardeau I 55 East

          207 S Mt Auburn Rd, Cape Girardeau
            2.5 out of 5.0
             
             

            Situated in Cape Girardeau, this hotel is 2.4 mi (3.8 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University ...

            Hampton Inn Cape Girardeau I 55 East$101

            Hampton Inn Cape Girardeau I 55 East$101
            Town House Inn Cape Giradreau

            Town House Inn Cape Giradreau

            505 North Kingshighway Street, Cape Girardeau
              2.5 out of 5.0
               
               

              Situated in Cape Girardeau, this motel is within 3 mi (5 km) of Cape Splash Family Aquatic Center, Southeast Missouri State University, and Isle Casino Cape ...

              Town House Inn Cape Giradreau$60

              Town House Inn Cape Giradreau$60
              Drury Inn & Suites Cape Girardeau

              Drury Inn & Suites Cape Girardeau

              3303 Campster Drive, Cape Girardeau
                3.0 out of 5.0
                 
                 

                Located in the heart of Cape Girardeau, this hotel is 2.7 mi (4.4 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State ...

                Drury Inn & Suites Cape Girardeau$95

                Drury Inn & Suites Cape Girardeau$95
                Holiday Inn Express Hotel & Suites Cape Girardeau I-55

                Holiday Inn Express Hotel & Suites Cape Girardeau I-55

                3253 William Street, Cape Girardeau
                  2.5 out of 5.0
                   
                   

                  Situated in a rural location, this hotel is 2.2 mi (3.6 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University ...

                  Holiday Inn Express Hotel & Suites Cape Girardeau I-55$109

                  Holiday Inn Express Hotel & Suites Cape Girardeau I-55$109
                  Candlewood Suites Cape Girardeau

                  Candlewood Suites Cape Girardeau

                  485 S Mount Auburn Rd, Cape Girardeau
                    2.5 out of 5.0
                     
                     

                    Situated in Cape Girardeau, this hotel is 3 mi (4.9 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Southeast Missouri State University ...

                    Candlewood Suites Cape Girardeau$93

                    Candlewood Suites Cape Girardeau$93
                    Americas Best Value Inn Cape Girardeau

                    Americas Best Value Inn Cape Girardeau

                    2011 North Kingshighway, Cape Girardeau
                      2.0 out of 5.0
                       
                       

                      Situated in Cape Girardeau, this motel is 0.7 mi (1.2 km) from Cape Splash Family Aquatic Center and within 6 mi (10 km) of Lazy L Safari Park and Southeast ...