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Choose from 168 Perryville Hotel Deals

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (582 reviews)
The rooms were spacious with black.out curtains. Beds and pillows were comfy. The only thing I can complain about was the breakfast. I expected a little more, but it wasn't awful. I thought it would include biscuits and gravy. Very minor issue. I would definitely stay there again.

Reviewed on May 3, 2026

Holiday Inn Express & Suites Perryville by IHG
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (995 reviews)
Suite is roomy. Jets in the hot tub not very strong at all. Very clean

Reviewed on May 9, 2026

Super 8 by Wyndham Perryville
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 27 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (432 reviews)
Staff was super friendly and helpful. Beds were wonderful! We will be back.

Reviewed on May 9, 2026

Days Inn by Wyndham Perryville
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.8/10 (132 reviews)
Nice for a quick stay.

Reviewed on Apr 23, 2026

Quality Inn Perryville I-55
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
  • 4 min drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9/10 Wonderful! (2 reviews)
Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would ...

Reviewed on May 3, 2026

The Atrium - A Boutique Hotel
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
  • 5 min drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.2/10 Wonderful! (18 reviews)
Beautiful place and staff was amazing!

Reviewed on Apr 16, 2026

Urban Lofts
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (761 reviews)
Good water temperature, soft towels. Very good mattress & pillows. HVAC was quiet, effective, but unobtrusive. Breakfast was good. Only issue for me was no potatoes. Will definitely stay again.

Reviewed on May 7, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,007 reviews)
Breakfast as always was on point with biscuits, gravy, breakfast potatoes, Mediterranean scramble eggs. Love the Bavarian style design. Drury keeps setting the standards for happy travelers.

Reviewed on May 9, 2026

Drury Inn & Suites Jackson MO
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (125 reviews)
Everything was great!!!

Reviewed on May 4, 2026

Tru By Hilton Cape Girardeau
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (765 reviews)
Air Conditioning was noisy, the bathroom door did not close. The linens were dingy. The furniture was subpar, lots of damage on them scratches and dings. The carpet was stained and dirty, the bathroom had water damage around the tub and there were cracks in the ceiling drywall.

Reviewed on Apr 27, 2026

Comfort Suites Jackson-Cape Girardeau
Holiday Inn Express Hotel & Suites Sparta by IHG

Holiday Inn Express Hotel & Suites Sparta by IHG

2.5 out of 5
1301 N Market St Sparta IL
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Sparta. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (395 reviews)
The first room I was sent to smelled like urine. The front desk staff were very accommodating and placed me in a new room, but there was no apology for the inconvenience or a "We'll have housekeeping check on that right away" kind of reaction. No towels in the fitness room, no water in the cooler. ...

Reviewed on May 7, 2026

Holiday Inn Express Hotel & Suites Sparta by IHG
Baymont by Wyndham Chester IL

Baymont by Wyndham Chester IL

2.5 out of 5
2150 State Street Chester IL
  • 35 min drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Chester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (389 reviews)
Nice place to stay…staff was very friendly & accommodating. It was the first time we saw a deer wandering around outside the window of our room. We recommend staying here in Popeye’s home town.

Reviewed on May 8, 2026

Baymont by Wyndham Chester IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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How many hotels are there in Perryville?

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