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Featured St. Charles Resorts & Hotels with Spas
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms in our reviews. ...
Home2 Suites by Hilton St. Charles St.Louis
32 Research Park Circle St. Charles MO
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz St. Charles MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and room service. Our guests praise the breakfast and the helpful ...
Country Inn & Suites by Radisson, St. Charles Historic District
1190 S Main St St. Charles MO
Fully refundable
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive St. Charles MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in St. Charles
- Historic Hotels in St. Charles
- Casinos in St. Charles
- Hotels with Free Parking in St. Charles
- Family Hotels in St. Charles
- Hotels with a Pool in St. Charles
- Hotels with an Indoor Pool in St. Charles
- Pet-friendly Hotels in St. Charles
- Hotel Wedding Venues in St. Charles
- Hotels with Hot Tubs in St. Charles
- Romantic Hotels in St. Charles
St. Charles Neighborhoods
Top Points of Interests in St. Charles
- Hotels near Ameristar Casino St. Charles
- Hotels near St Charles Convention Center
- Hotels near Lindenwood University
- Hotels near Historic Main Street
- Hotels near Family Arena
- Hotels near Fast Lane Classic Cars
- Hotels near Katy Trail
- Hotels near Missouri Bluffs Golf Course
- Hotels near Lewis & Clark Boathouse and Nature Center
- Hotels near First Missouri State Capitol Historic Site
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near Jaycee Park
- Hotels near Frenchtown Heritage Museum
- Hotels near Missouri Artists on Main
- Hotels near Mississippi River
- Hotels near Missouri River
Cities near St. Charles
- Maryland Heights Hotels (6.33 mi)
- Chesterfield Hotels (9.49 mi)
- St. Peters Hotels (6.7 mi)
- O'Fallon Hotels (11 mi)
- Fenton Hotels (19.25 mi)
- Innsbrook Hotels (29.82 mi)
- Edwardsville Hotels (27.79 mi)
- Wentzville Hotels (19.2 mi)
- Kirkwood Hotels (14.96 mi)
- Collinsville Hotels (28.73 mi)
- Alton Hotels (18.27 mi)
- Grafton Hotels (13.05 mi)
- Hazelwood Hotels (6.19 mi)
- Arnold Hotels (25.37 mi)
- Washington Hotels (31.97 mi)
- Richmond Heights Hotels (14.6 mi)
- Bridgeton Hotels (4.85 mi)
- Brentwood Hotels (14.23 mi)
- Eureka Hotels (20.94 mi)
- East St. Louis Hotels (22.41 mi)