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Featured St. Charles Resorts & Hotels with Spas
Hampton Inn St. Charles St. Peters
3720 W Clay St, St. Charles, MO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in ...
Ameristar Casino Resort and Spa
1 Ameristar Blvd, St. Charles, MO
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 5 restaurants. Our guests praise the helpful staff and the ...
Research Park Inn St Louis West – Chesterfield
32 Research Park Circle, St. Charles, MO
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz, St. Charles, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in St. Charles. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and ...
Country Inn & Suites by Radisson, St. Charles, MO
1190 S Main St, St. Charles, MO
Fully refundable
Book a stay at this business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive, St. Charles, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
St. Charles Neighborhoods
Top Points of Interests in St. Charles
- Hotels near Ameristar Casino St. Charles
- Hotels near Lindenwood University
- Hotels near St Charles Convention Center
- Hotels near Historic Main Street
- Hotels near Family Arena
- Hotels near Fast Lane Classic Cars
- Hotels near Katy Trail
- Hotels near Lewis & Clark Boathouse and Nature Center
- Hotels near Missouri Bluffs Golf Course
- Hotels near First Missouri State Capitol Historic Site
- Hotels near Jaycee Park
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near Enterprise Center
- Hotels near St. Louis Union Station
- Hotels near Busch Stadium
- Hotels near St. Louis Zoo
- Hotels near Gateway Arch
- Hotels near Six Flags St. Louis
- Hotels near Washington University in St. Louis
- Hotels near Forest Park
Cities near St. Charles
- Maryland Heights Hotels (6.33 mi)
- Chesterfield Hotels (9.49 mi)
- Innsbrook Hotels (29.82 mi)
- Bridgeton Hotels (4.85 mi)
- Collinsville Hotels (28.73 mi)
- St. Peters Hotels (6.7 mi)
- O'Fallon Hotels (11 mi)
- Alton Hotels (18.27 mi)
- Edwardsville Hotels (27.79 mi)
- Eureka Hotels (20.94 mi)
- Ozarks Hotels (156.82 mi)
- Wentzville Hotels (19.2 mi)
- Grafton Hotels (13.05 mi)
- East St. Louis Hotels (22.41 mi)
- Fenton Hotels (19.25 mi)
- Arnold Hotels (25.37 mi)
- Hazelwood Hotels (6.19 mi)
- Kirkwood Hotels (14.96 mi)
- Southern Illinois Hotels (93.9 mi)
- Washington Hotels (31.97 mi)
Car Rentals Near St. Charles
- Car rentals in Maryland Heights
- Car rentals in Chesterfield
- Car rentals in Innsbrook
- Car rentals in Bridgeton
- Car rentals in Collinsville
- Car rentals in St. Peters
- Car rentals in O'Fallon
- Car rentals in Alton
- Car rentals in Edwardsville
- Car rentals in Eureka
- Car rentals in Ozarks
- Car rentals in Wentzville
- Car rentals in Grafton
- Car rentals in East St. Louis
- Car rentals in Fenton
- Car rentals in Arnold
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels
Top Booked Hotels in St. Charles
- Ameristar Casino Resort and Spa
- Embassy Suites by Hilton St. Louis St. Charles
- Country Inn & Suites by Radisson, St. Charles, MO
- Country Inn & Suites by Radisson, St. Peters, MO
- Hyatt Regency St. Louis at The Arch
- Hollywood Casino & Hotel St. Louis
- Clayton Plaza Hotel & Extended Stay
- Best Western St. Louis-Kirkwood Route 66
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza