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Luxury Hotels in South Carolina Midlands

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Featured Luxury South Carolina Midlands

The Ballantyne, A Luxury Collection Hotel, Charlotte

The Ballantyne, A Luxury Collection Hotel, Charlotte

5 out of 5
10000 Ballantyne Commons Pkwy Charlotte NC
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Charlotte. Enjoy free WiFi, 2 indoor pools, and a full-service spa. Our guests praise the helpful staff and the property ...
The Ballantyne, A Luxury Collection Hotel, Charlotte
The Willcox

The Willcox

3.5 out of 5
100 Colleton Avenue SW Aiken SC
Book a stay at this business-friendly hotel in Aiken. Enjoy free breakfast, free parking, and a fitness center. Popular attractions The Alley and Aiken County ...
The Willcox
The Mantissa Hotel

The Mantissa Hotel

3 out of 5
130 East Carolina Ave Hartsville SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
The Mantissa Hotel
Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg

2 out of 5
3620 Saint Matthews Rd Orangeburg SC
Fully refundableReserve now, pay when you stay
Stay at this motel in Orangeburg. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Travelodge by Wyndham Orangeburg
Carriage House Inn

Carriage House Inn

3 out of 5
139 Laurens Street, Northwest  Aiken SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Aiken. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Carriage House Inn
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area

2 out of 5
1047 Riverview Rd Rock Hill SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Rock Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Microtel Inn & Suites by Wyndham Rock Hill/Charlotte Area
Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel

3 out of 5
104 Court Avenue East Greenwood SC
Fully refundable
Book a stay at this business-friendly hotel in Greenwood. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Inn on the Square, an Ascend Collection Hotel
Sheraton Columbia Downtown Hotel

Sheraton Columbia Downtown Hotel

3.5 out of 5
1400 Main St Columbia SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
Sheraton Columbia Downtown Hotel
Baymont by Wyndham Greenwood

Baymont by Wyndham Greenwood

2.5 out of 5
109 Enterprise Ct Greenwood SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Baymont by Wyndham Greenwood
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
Red Roof Inn Santee
Super 8 by Wyndham Columbia SC / Ft. Jackson

Super 8 by Wyndham Columbia SC / Ft. Jackson

2 out of 5
5321 Forest Dr Columbia SC
Fully refundableReserve now, pay when you stay
Stay at this motel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Palmetto ...
Super 8 by Wyndham Columbia SC / Ft. Jackson
Days Inn by Wyndham Dillon

Days Inn by Wyndham Dillon

2 out of 5
823 Radford Blvd Dillon SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Dillon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Days Inn by Wyndham Dillon
See all 3,055 properties in South Carolina Midlands
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.