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Hotels in Santee

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Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (720 reviews)
It was a clean room and quiet. It was nice being right off of 95. Breakfast was good…suited us!

Reviewed on Feb 8, 2026

Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,424 reviews)
Room was clean. Staff helpful

Reviewed on Feb 7, 2026

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
The room was fine, the breakfast fair, the staff great.

Reviewed on Feb 5, 2026

Fairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,001 reviews)
Staff both at the desk and in the dining room made us feel very welcome.

Reviewed on Feb 7, 2026

Hampton Inn Santee-I-95
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
  • 6 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (1,000 reviews)
Bed was so comfy….clean. Great staff.

Reviewed on Feb 4, 2026

Holiday Inn Santee by IHG
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
Clean, spacious room. Comfortable bed. Quiet

Reviewed on Feb 8, 2026

Best Western Plus Santee Inn
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,002 reviews)
Clean room

Reviewed on Feb 9, 2026

Comfort Inn & Suites Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (697 reviews)
Front desk staff friendly and professional. Clean rooms

Reviewed on Feb 8, 2026

Travelodge by Wyndham Santee
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway Santee SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
5.8/10 (473 reviews)
Check-in was quick and easy, and the room was lovely. It was nice to have breakfast (with fresh fruit) made available in the morning. However, this is a large, 2-story motel. It is a more vintage venue and as an elder person I have this advice: If you cannot do stairs, please request a first-floor ...

Reviewed on Feb 2, 2026

Quality Inn & Suites
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions Santee Cooper Country Club and Santee ...
6.2/10 (549 reviews)
The room was the cleanest of many hotels on a long road trip; cleaner than fancier hotels. Don't freak out when you drive up....it looks like an abandoned building...but the rooms are nice

Reviewed on Jan 4, 2026

Ramada by Wyndham Santee I-95
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (643 reviews)
Room was nice and clean. Oly problem was the TV went out but I had a book to read.

Reviewed on Feb 7, 2026

Red Roof Inn Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.6/10 (443 reviews)
Had trouble with the remote, but they came and fixed it. Staff was friendly and breakfast was OK.

Reviewed on Feb 13, 2026

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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Frequently Asked Questions About Santee hotels

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How many hotels are there in Santee?

With over 303 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

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