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Hotels in Santee

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Tonight Jun 21 - Jun 22Next weekend Jun 27 - Jun 29

Choose from 280 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,298 reviews)
"Good accommodation and friendly staff. Would stay there again"

Reviewed on Jun 15, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (448 reviews)
"The young front desk receptionist , Skyler, was inhospitable. No greeting, failed to give us complimentary water and popcorn. She was more concerned with her cell phone. Lauren, the other receptionist ,was exceptional! She came up to our room to help with our TV. She is a definite asset to your hotel!!! ..."

Reviewed on Jun 18, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,000 reviews)
"Road trip stopover while traveling with out dog. Fourth time we've stayed here and it lived up to our expectations - clean and comfortable room, friendly and efficient staff, great location, excellent breakfast."

Reviewed on Jun 16, 2025

Fairfield Inn & Suites by Marriott Santee
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
5.8/10 (391 reviews)
"Great price on the room and well worth the price!"

Reviewed on Jun 15, 2025

Quality Inn & Suites
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (894 reviews)
Include breakfast if you stay here as it is cheapr
"Nice place to stay when traveling 95. They have a restaurant with nobody in it. We had breakfast included but I had to go to the desk to find out where the waitress was. The breakfast was very good, but if you are looking for an early start this is not the place for you."

Reviewed on Jun 10, 2025

Holiday Inn Santee by IHG
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,000 reviews)
"Nice stay for overnight. Great pool!"

Reviewed on Jun 12, 2025

Best Western Plus Santee Inn
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
"They breakfast was amazing nothing like a good breakfast"

Reviewed on Jun 18, 2025

Comfort Inn & Suites Santee
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,001 reviews)
"Comfortable room, great breakfast, except for an auto alarm going off in the early morning, it was a perfect stay."

Reviewed on Jun 15, 2025

Hampton Inn Santee-I-95
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (634 reviews)
"Very nice anf clean"

Reviewed on Jun 17, 2025

Travelodge by Wyndham Santee
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (613 reviews)
"it was clean and the staff was friendly"

Reviewed on Jun 13, 2025

Red Roof Inn Santee
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
6.2/10 (523 reviews)
"Management has done the best they could with an old worn property. It was clean and presentable. They are taking care of it without putting money into the property."

Reviewed on Jun 14, 2025

Ramada by Wyndham Santee I-95
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
6.6/10 (426 reviews)
"Resturants and stores close by"

Reviewed on May 15, 2025

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 280 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as . In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

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Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santee?

With over 280 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as .

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.