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Choose from 315 Santee Hotel Deals
Tru By Hilton Santee
Best Western Plus Santee Inn
Baymont by Wyndham Santee
"The staff is friendly and professional. I have stay at the baymont several times and have always been greeted and helped. I get the room I have requested. And the breakfast is wonderful. I eat the yogurt and muffins and my partner loves the waffles. If I was t pleased with the baymont I certainly ..."
Reviewed on Jul 17, 2026
Fairfield Inn & Suites by Marriott Santee
"I travel a whole lot and normally take a break at this hotel because the staff is professional, nice and friendly. It's a nice and clean hotel. The staff is amazing I recommend this hotel and give it 5 stars."
Reviewed on Jul 13, 2026
Hampton Inn Santee-I-95
"Modern-looking, walk-in shower, space and snacks, my son loved the waffles!"
Reviewed on Jul 15, 2026
Comfort Inn & Suites Santee
"Great location and staff"
Reviewed on Jul 16, 2026
Quality Inn & Suites Santee I-95
"Shampoo dispenser was out, no coffee cups and only decaf, paint falling from ceiling, floors dirty."
Reviewed on Jul 16, 2026
Ramada by Wyndham Santee I-95
"Posted as a pillow top bed there was no pillow top. It was so hard. It was like sleeping on stone. Brown water coming out of the showerhead. Plugs didn’t fit in the sockets securely and actually fell out a couple times. There was hair on the side of the tub. Door jam was stuck. Screws coming out ..."
Reviewed on Jul 14, 2026
Travelodge by Wyndham Santee
"The sink in my room did not work, the parking was good, the room was clean, the staff was very nice and the air conditioning was good. The only problem was the sink."
Reviewed on Jul 16, 2026
Holiday Inn Santee by IHG
"Beds & pillows are very comfortable. Amenities needs some upgrading....I brewed a keurig cup coffee & grinds were in the cup. Toilet to upgrade & shower curtain too small. But very clean!"
Reviewed on May 30, 2026
Super 8 by Wyndham Santee/I-95
Red Roof Inn Santee
Find cheap hotels in Santee
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.
Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 315 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.
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Frequently Asked Questions About Santee hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Santee?
With over 315 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.
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- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee National Golf Club
- Hotels near Lake Marion
- Hotels near Congaree National Park
- Hotels near South Carolina State University
- Hotels near Wyboo Golf Club
- Hotels near Edisto Memorial Gardens
- Hotels near Santee National Wildlife Refuge
- Hotels near Santee Indian Mound and Fort Watson Site
- Hotels near St. George Country Club
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