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Howard Johnson by Wyndham Florence
"2 night stay. Two separate occasions, hotel staff tried to enter the room without knocking. Without prior notice or complaint by us, 3 hotel staff, a female and 2 males unexpectedly came to the room to check on the tv that working without an issue raised by us. The female staff left the room leaving ..."
Reviewed on Nov 9, 2026

Comfort Inn & Suites Florence Center Area
"I was not impressed. The room is outdated. Smelt old. Two significant tears in the rug. The mattress was comfortable.👍 I didn’t find anything I’d consider eating for Breakfast. not even the coffee. The staff was friendly"
Reviewed on Nov 10, 2026

Park Inn by Radisson Florence, SC
"A clean, comfortable room with a helpful staff and nice breakfast."
Reviewed on Nov 10, 2026

Hampton Inn & Suites Florence Center
"La cama muy cómoda, los espacios bien utilizados, excelente ducha y productos de baño. El desayuno increíble"
Reviewed on Nov 8, 2026

Hyatt Place Florence Downtown

Spark by Hilton Florence North I-95, SC

SpringHill Suites by Marriott Florence
"The hotel pool amd rooms were nice, and there was a big variety for breakfast. Our toilet didn't work well, and the tub slanted inward to the middle but otherwise enjoyable."
Reviewed on Nov 3, 2026

Days Inn by Wyndham Florence Near Civic Center

TownePlace Suites by Marriott Florence

Quality Inn & Suites Florence Civic Center

La Quinta Inn & Suites by Wyndham Florence

Tru by Hilton Florence I-95
Find cheap hotels in Florence
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Florence.
Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Florence’s 419 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $72. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Florence. No matter your reason for visiting Florence, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Florence hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Florence for as low as $72.
How many hotels are there in Florence?
With over 419 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $72.
How to find cheap car rentals in Florence?
Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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