Search Cheap Flights to
South Carolina Midlands

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

South Carolina Midlands Flights as Low as $162

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jun 13 - Tue, Jun 30
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$162 Roundtrip, found 4 hours ago
$162
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Sat, Jun 13 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Jun 30, priced at $162 found 4 hours ago
American Airlines
Thu, Jun 18 - Tue, Jun 30
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$218 Roundtrip, just found
$218
Roundtrip
just found
Select American Airlines flight, departing Thu, Jun 18 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Jun 30, priced at $218 just found
Delta
Thu, Jun 18 - Tue, Jun 30
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$223 Roundtrip, just found
$223
Roundtrip
just found
Select Delta flight, departing Thu, Jun 18 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Jun 30, priced at $223 just found
Delta
Fri, Jul 3 - Tue, Jul 21
JFK
John F. Kennedy Intl.
CLT
Charlotte-Douglas Intl.
$238 Roundtrip, just found
$238
Roundtrip
just found
Select Delta flight, departing Fri, Jul 3 from John F. Kennedy Intl. to Charlotte-Douglas Intl., returning Tue, Jul 21, priced at $238 just found
United
Thu, Sep 3 - Tue, Sep 8
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$242 Roundtrip, found 4 hours ago
$242
Roundtrip
found 4 hours ago
Select United flight, departing Thu, Sep 3 from Newark Liberty Intl. Airport to Charlotte-Douglas Intl., returning Tue, Sep 8, priced at $242 found 4 hours ago
Bargain Flight
Wed, Jun 3 - Wed, Jun 17
LGA
LaGuardia
CAE
Columbia Metropolitan
$248 Roundtrip, found 1 day ago
$248
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Jun 3 from LaGuardia to Columbia Metropolitan, returning Wed, Jun 17, priced at $248 found 1 day ago
Delta
Thu, Oct 22 - Sun, Oct 25
JFK
John F. Kennedy Intl.
AGS
Augusta Regional
$277 Roundtrip, found 6 hours ago
$277
Roundtrip
found 6 hours ago
Select Delta flight, departing Thu, Oct 22 from John F. Kennedy Intl. to Augusta Regional, returning Sun, Oct 25, priced at $277 found 6 hours ago
Delta
Tue, Oct 20 - Tue, Oct 27
EWR
Newark Liberty Intl. Airport
AGS
Augusta Regional
$277 Roundtrip, found 7 hours ago
$277
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, Oct 20 from Newark Liberty Intl. Airport to Augusta Regional, returning Tue, Oct 27, priced at $277 found 7 hours ago
American Airlines
Tue, Jul 21 - Tue, Jul 28
LGA
LaGuardia
FLO
Florence Regional
$283 Roundtrip, found 3 hours ago
$283
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 21 from LaGuardia to Florence Regional, returning Tue, Jul 28, priced at $283 found 3 hours ago
United
Sat, Jul 4 - Mon, Jul 20
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select United flight, departing Sat, Jul 4 from Newark Liberty Intl. Airport to Columbia Metropolitan, returning Mon, Jul 20, priced at $296 found 1 day ago
Bargain Flight
Thu, Jun 4 - Tue, Jun 9
SLC
Salt Lake City Intl.
CLT
Charlotte-Douglas Intl.
$315 Roundtrip, found 4 hours ago
$315
Roundtrip
found 4 hours ago
Select Bargain Flight flight, departing Thu, Jun 4 from Salt Lake City Intl. to Charlotte-Douglas Intl., returning Tue, Jun 9, priced at $315 found 4 hours ago
Delta
Tue, Jun 2 - Wed, Jun 10
LGA
LaGuardia
AGS
Augusta Regional
$323 Roundtrip, found 6 hours ago
$323
Roundtrip
found 6 hours ago
Select Delta flight, departing Tue, Jun 2 from LaGuardia to Augusta Regional, returning Wed, Jun 10, priced at $323 found 6 hours ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$344 Roundtrip, found 7 hours ago
$344
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $344 found 7 hours ago
American Airlines
Tue, Jul 14 - Sat, Jul 25
JFK
John F. Kennedy Intl.
FLO
Florence Regional
$377 Roundtrip, found 1 day ago
$377
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 14 from John F. Kennedy Intl. to Florence Regional, returning Sat, Jul 25, priced at $377 found 1 day ago
JetBlue Airways
Sat, Sep 26 - Tue, Sep 29
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$383 Roundtrip, found 2 days ago
$383
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Sat, Sep 26 from Newark Liberty Intl. Airport to Charlotte-Douglas Intl., returning Tue, Sep 29, priced at $383 found 2 days ago
United
Thu, Jun 11 - Sat, Jun 13
SLC
Salt Lake City Intl.
CAE
Columbia Metropolitan
$427 Roundtrip, found 1 day ago
$427
Roundtrip
found 1 day ago
Select United flight, departing Thu, Jun 11 from Salt Lake City Intl. to Columbia Metropolitan, returning Sat, Jun 13, priced at $427 found 1 day ago

Cheap Flights to South Carolina Midlands

Fall in love at first flight with your vacation to South Carolina Midlands by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to South Carolina Midlands on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in South Carolina Midlands, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to South Carolina Midlands

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to South Carolina Midlands with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to South Carolina Midlands?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to South Carolina Midlands are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to South Carolina Midlands?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to South Carolina Midlands.

What airport is best to fly into South Carolina Midlands?

When you’re planning your trip to South Carolina Midlands, convenience is the name of the game. Luckily, South Carolina Midlands Columbia Metropolitan Airport is nearby so you can deplane and get going on checking off everything on your South Carolina Midlands must-do list.

How much are flights to South Carolina Midlands?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to South Carolina Midlands on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $162, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to South Carolina Midlands?

The trick to saving a stack of cash on your flight to South Carolina Midlands? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $162 right now, why wait?

South Carolina Midlands Flight Information
Destination airport
Charlotte-Douglas Intl.
Destination airport IATA code
CLT
Roundtrip price
$56

Last Minute Hotel Deals in South Carolina Midlands

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr Columbia SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (2,072 reviews)
"Property was a bit outdated. Elevators and halls could use some work. Room was clean, but definitely could’ve been more clean. Linens need a lot of work. Carpet was sticky if the room got humid, could definitely benefit from a shampoo. Very hard to prop up in bed with the pillows provided."

Reviewed on May 26, 2026

Get rates
Hilton Garden Inn Columbia/Harbison
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,673 reviews)
"This place is the old South. Breakfast was poor, no real food, just processed. Room was big and clean. Staff mostly clueless or slow . It’s worth maybe 50-60 a night, no more"

Reviewed on May 26, 2026

Get rates
Howard Johnson by Wyndham Florence
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (157 reviews)
"Great spot to stay for a quick over night when traveling!"

Reviewed on May 25, 2026

Get rates
Quality Inn & Suites Florence Civic Center
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,283 reviews)
"Perfect place with friendly staff!"

Reviewed on May 27, 2026

Get rates
Park Inn by Radisson Florence, SC
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
7333 Garners Ferry Rd Columbia SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Millwood Plantation Ruins and ...
8/10 Very Good! (1,007 reviews)
"Nice place to stay for a reasonable price. Our room was great and appeared newly renovated. Some amenities were not available due to remodeling, like the business center. Breakfast could use more variety instead of egg patties and sausage patties every day. Bacon or sausage links would be welcome. ..."

Reviewed on May 27, 2026

Get rates
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street Columbia SC
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Riverbanks Zoo and Garden and EdVenture ...
9.4/10 Exceptional! (674 reviews)
"Everyone was so welcoming upon entering the hotel , very clean, great breakfast! Thank you , if I am in Columbia ,SC again will definitely stay here again. Love the pillows."

Reviewed on May 26, 2026

Get rates
Tru By Hilton Columbia Downtown
Courtyard by Marriott Columbia Downtown at USC

Courtyard by Marriott Columbia Downtown at USC

3 out of 5
630 Assembly St Columbia SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,002 reviews)
"Great location for the colonial arena ! Clean and accommodating!"

Reviewed on May 27, 2026

Get rates
Courtyard by Marriott Columbia Downtown at USC
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
1901 Rockland Rd Columbia SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,080 reviews)
"Needs work"

Reviewed on May 26, 2026

Get rates
Sleep Inn Columbia
See all 3,291 properties in South Carolina Midlands
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Baymont by Wyndham Columbia Northwest

Baymont by Wyndham Columbia Northwest

2.5 out of 5
347 Zimalcrest Drive Columbia SC
Book a stay at this family-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Riverbanks Zoo and Garden and BTM ...
5.6/10 (1,001 reviews)
"1. At check in the coffee in the was water . 2. Unable to watch regular channels on tv, all they had was streaming TV. When all I wanted was watch was the NBA PLAYOFFS on regular TV. For 4 days I couldn't watch regular channels. 3. I booked the for 4 days everytime I went out in evening I to go back ..."

Reviewed on May 27, 2026

Get rates
Baymont by Wyndham Columbia Northwest
Country Inn & Suites by Radisson, Columbia Airport, SC

Country Inn & Suites by Radisson, Columbia Airport, SC

2.5 out of 5
2245 Airport Blvd Cayce SC
Book a stay at this business-friendly hotel in Cayce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,000 reviews)
"The room was excellent, staff and parking was good. The only negative thing I will say is the breakfast not hot just Luke warm it was okay/good just needs to be hot. Other than that it was a fantastic experience. I would rate it a A+"

Reviewed on May 27, 2026

Get rates
Country Inn & Suites by Radisson, Columbia Airport, SC
Doubletree by Hilton Columbia, SC

Doubletree by Hilton Columbia, SC

4 out of 5
2100 Bush River Road Columbia SC
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8/10 Very Good! (1,001 reviews)
"Everything was perfect! The staff was very helpful, & the room was clean. Would definitely recommend this hotel!!"

Reviewed on May 26, 2026

Get rates
Doubletree by Hilton Columbia, SC
Hampton Inn Columbia-I-26 Airport

Hampton Inn Columbia-I-26 Airport

2.5 out of 5
1094 Chris Dr West Columbia SC
Stay at this hotel in West Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
"The bathroom was the thing most lacking. There was no counter space, no towel racks except a small one in front of the sink, toilet was very low and had no grab bars, and there was only one grab bar in the bathtub. Housekeeping services only every other day which would not have been a big problem ..."

Reviewed on May 26, 2026

Get rates
Hampton Inn Columbia-I-26 Airport
Hilton Garden Inn Columbia Airport

Hilton Garden Inn Columbia Airport

3 out of 5
110 McSwain Drive West Columbia SC
Book a stay at this business-friendly hotel in West Columbia. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
"Staff was very helpful and accommodating ."

Reviewed on May 24, 2026

Get rates
Hilton Garden Inn Columbia Airport
Clarion Inn Columbia Airport

Clarion Inn Columbia Airport

2.5 out of 5
500 Chris Dr West Columbia SC
Book a stay at this business-friendly hotel in West Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6/10 (1,000 reviews)
"The room itself was clean and beds comfortable. The room was quiet. But the lock mechanism on my door would intermittently work and I got locked out 3 times and had to get my room key reprogrammed. Then the key machines went down and the concierge was as helpful as he could be. This wasn’t his fault ..."

Reviewed on May 25, 2026

Get rates
Clarion Inn Columbia Airport
See all 3,291 properties in South Carolina Midlands
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.