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Santa Cruz

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Featured Santa Cruz Hotels

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5, Seville, Seville
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Seville. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the pool and the bar in our reviews. Popular ...
9.2/10 Wonderful! (1,029 reviews)
Amazing spa, room very clean, good bar area with amazing choice, staff very helpful at all times

Reviewed on Oct 28, 2025

Las Casas de la Judería, Sevilla Historic City Center
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35, Seville, Seville
Stay at this 4-star hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool in our reviews. Popular ...
9.4/10 Exceptional! (1,094 reviews)
Room is clean. Location is good. My room facing internal corridors, poor facing.

Reviewed on Oct 30, 2025

Hotel Rey Alfonso X
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21, Seville, Seville
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the breakfast and the pool ...
9.6/10 Exceptional! (1,540 reviews)
Helpful staff and a great location. I’d be happy to stay there again.

Reviewed on Oct 28, 2025

Hotel Fernando III
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6, Seville, Seville
Fully refundableReserve now, pay when you stay
Stay at this 4-star boutique hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
9.6/10 Exceptional! (1,052 reviews)
Lovely hotel in central Seville. Beautifully decorated and looked after. Helpful and pleasant staff. Air con was appreciated at 30 degrees in late October! Relaxed breakfast and convenient area to stay in. Everything easily walkable from the hotel.

Reviewed on Oct 27, 2025

Hotel Amadeus Sevilla
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9, Seville, Seville
Fully refundable
Book a stay at this family-friendly hotel in Seville. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,004 reviews)
Very friendly and helpful. Great location.

Reviewed on Oct 26, 2025

Hotel Murillo
Petit Palace Santa Cruz

Petit Palace Santa Cruz

4 out of 5
Munoz y Pabón 18, Seville, Seville
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
8.8/10 Excellent! (958 reviews)
El staff muy dispuesto, Rubén en el lobby muy atento, la ubicación excelente. No tuvimos ningún problema. Súper recomendado!

Reviewed on Oct 16, 2025

Petit Palace Santa Cruz
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2, Seville, Seville
Stay at this 5-star luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,008 reviews)
Beautiful property. Great breakfast, and a wonderful bar with nightly entertainment.

Reviewed on Oct 30, 2025

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Don Carlos Alonso Chaparro 3, Seville, Seville
Stay at this 4-star boutique hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the property ...
9.8/10 Exceptional! (841 reviews)
Excellent staff provided seamless travel to and from the airport and check-in experience. They also provided complimentary drinks while we were waiting for our return taxi to the airport. Very helpful staff...and the hotel ambience was lovely

Reviewed on Oct 30, 2025

Hotel Boutique Casa del Poeta Sevilla
Hotel Doña Maria

Hotel Doña Maria

4 out of 5
Don Remondo 19, Seville, Seville
Stay at this 4-star historic hotel in Seville. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the bar and the helpful staff in our ...
8.8/10 Excellent! (993 reviews)
The room was so pretty and each room has a different style. Staff were so friendly . Breakfast was so good.

Reviewed on Oct 26, 2025

Hotel Doña Maria
Hotel Convento La Gloria

Hotel Convento La Gloria

3 out of 5
Calle Argote de Molina, 26 - 28, Seville, Seville
Stay at this 3-star historic hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (614 reviews)
Excelent hotel

Reviewed on Oct 25, 2025

Hotel Convento La Gloria
EME Catedral Mercer Hotel

EME Catedral Mercer Hotel

5 out of 5
Calle Alemanes 27, Seville, Seville
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Seville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (991 reviews)
Excelente atención de todo el personal de EME, el desayuno delicioso, la terraza Bar increíbles vistas de la Giralda, todo el Staff es una familia que te acogen en tus días de vacaciones, Ema & Victor gracias por sus atenciones desde antes de llegar al hotel, atentos siempre para una recomendación ...

Reviewed on Oct 28, 2025

EME Catedral Mercer Hotel
Legado Alcázar Hotel

Legado Alcázar Hotel

4 out of 5
Calle Mariana de Pineda, 18, Seville, Sevilla
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Seville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the helpful staff in our ...
9.6/10 Exceptional! (940 reviews)
I stayed here twice during my visit to Sevillaz What an amazing place. You will not be disappointed!

Reviewed on Oct 28, 2025

Legado Alcázar Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Cruz

Seville is a city that has a lot going on, but you have your sights set on Santa Cruz. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Cruz has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Cruz hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Seville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Cruz underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Cruz city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Cruz cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Cruz at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $83
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Cruz hotel you want, book it, and never look back. Because your great escape is ahead of you.