Hotels Near
Medical Center District

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Featured Medical Center District Hotels

Clarion Pointe near Medical Center
Clarion Pointe near Medical Center
2.5 out of 5
4803 Manitou, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,194 reviews)
"Quit very clean"

Reviewed on May 27, 2024

Clarion Pointe near Medical Center
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (3,030 reviews)
"Nice breakfast"

Reviewed on May 31, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundable
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
6.8/10 (1,418 reviews)
"The suite was nice and had a lot of room. The carpet needed cleaning or replaced but overall everything was up to par. We would stay again."

Reviewed on May 27, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center
3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.2/10 Wonderful! (1,095 reviews)
"Staff was great and friendly. Property was clean, breakfast and dinner options were good."

Reviewed on May 27, 2024

Drury Inn & Suites San Antonio Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (999 reviews)
"Nice location"

Reviewed on May 20, 2024

Courtyard by Marriott Medical Center San Antonio
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical Center
3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the breakfast and the ...
8.2/10 Very Good! (1,004 reviews)
"The restaurant was nice and the shuttle is convenient. Was NOT a fan of having a room overlooking the center of the building and not seeing the outside. Made the room very dark."

Reviewed on May 29, 2024

San Antonio Marriott Northwest Medical Center
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (3,610 reviews)
"I recommend taking the stress out of dealing with parking and utilizing the valet service. The staff is friendly and attentive."

Reviewed on May 30, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
7.4/10 Good! (2,704 reviews)
"Central location. Breakfast was very good"

Reviewed on May 29, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,584 reviews)
"It was nice, i felt safe inside too"

Reviewed on May 28, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (2,864 reviews)
"Picture of the room looks bigger than the actual size. Nice & quiet area & the place is clean."

Reviewed on May 28, 2024

Hotel Gibbs Downtown Riverwalk
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the pool in ...
8.8/10 Excellent! (2,835 reviews)
"The history of the building."

Reviewed on May 31, 2024

Menger Hotel
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,747 reviews)
"Love this hotel stay here a few times it’s clean. It’s friendly. The pool is nice. The hot tub is great. The ambience is beautiful."

Reviewed on May 31, 2024

Hotel Contessa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $54
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.