Hotels Near
Medical Center District

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Featured Medical Center District Hotels

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3 out of 5
8318 I-10 West, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
6.8/10 (1,404 reviews)
"It was a very last minute trip for the weekend & was looking for something cheap. I got there before the check in time and they had my room ready. Everything was quick & the service was great!"

Reviewed on May 6, 2024

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
8.4/10 Very Good! (2,996 reviews)
"Breakfast was great, room & common areas were clean. The front desk staff were all very friendly & helpful."

Reviewed on May 13, 2024

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San Antonio
3 out of 5
8585 Marriott Dr, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (1,002 reviews)
"Had several nice stays here."

Reviewed on May 7, 2024

Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (3,575 reviews)
"Lobby was really nice. Room was okay. Some maintenance needed on bathroom"

Reviewed on May 14, 2024

Riverwalk Plaza
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
3 out of 5
303 Blum Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
7.4/10 Good! (2,643 reviews)
"Front desk was fabulous! Room wasn’t the best and wasn’t the worse, everything is older, soaps Was not enough for 5 people! Very weird!"

Reviewed on May 13, 2024

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport
2.5 out of 5
850 Halm Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (2,559 reviews)
"Its good but not great."

Reviewed on May 14, 2024

La Quinta Inn & Suites by Wyndham San Antonio Airport
Menger Hotel
Menger Hotel
3.5 out of 5
204 Alamo Plaza, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the breakfast and the pool in ...
8.8/10 Excellent! (2,827 reviews)
"The Menger is a historic hotel that’s close to much of what’s going on in San Antonio. We stayed on the historic side of the hotel, so the room was charming, but also comfortable. I would have liked more towels, but it was super late when we got back so we didn’t want to disturb anyone to get them. ..."

Reviewed on May 12, 2024

Menger Hotel
Hotel Gibbs Downtown Riverwalk
Hotel Gibbs Downtown Riverwalk
3.5 out of 5
105 N Alamo, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (2,812 reviews)
"We really enjoyed our stay. The staff was very helpful and friendly. And the breakfast we great. Not a cheap tasteless breakfast."

Reviewed on May 13, 2024

Hotel Gibbs Downtown Riverwalk
Crockett Hotel
Crockett Hotel
3 out of 5
320 Bonham, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (1,689 reviews)
"Old building"

Reviewed on May 15, 2024

Crockett Hotel
Hotel Contessa
Hotel Contessa
4 out of 5
306 W Market Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
8.8/10 Excellent! (2,748 reviews)
"The staff are all incredible.. from the valet to maintenance to front desk to the ambler!!"

Reviewed on May 13, 2024

Hotel Contessa
Drury Plaza Hotel San Antonio Riverwalk
Drury Plaza Hotel San Antonio Riverwalk
3 out of 5
105 S Saint Marys Street, San Antonio, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,591 reviews)
"Wonderful staff great location"

Reviewed on May 13, 2024

Drury Plaza Hotel San Antonio Riverwalk
Omni La Mansion del Rio
Omni La Mansion del Rio
4 out of 5
112 College St, San Antonio, TX
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9.2/10 Wonderful! (2,133 reviews)
"Nice view from our room. Friendly and helpful staff."

Reviewed on May 15, 2024

Omni La Mansion del Rio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center District

San Antonio is a city that has a lot going on, but you have your sights set on Medical Center District. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center District has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center District hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Antonio so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center District underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center District city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center District cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center District at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $67
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center District hotel you want, book it, and never look back. Because your great escape is ahead of you.