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Hotels in South San Diego

Choose from 7561 South San Diego Hotel Deals

Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center

4 out of 5
1000 H Street, Chula Vista, CA
  • 15 min drive from Las Americas Premium Outlets
Stay at this 4-star spa hotel in Chula Vista. Enjoy 3 outdoor pools, a full-service spa, and 8 restaurants. Popular attractions San Diego Bay and Hotel del Coronado ...
8/10 Very Good! (44 reviews)
"Elliot was very helpful in resolving issues during the check in process. Other customer service reps were not so helpful and doesn’t know what they are doing."

Reviewed on Jul 21, 2025

Gaylord Pacific Resort & Convention Center
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
  • 8 min drive from Las Americas Premium Outlets
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,410 reviews)
"Excellent staff service !"

Reviewed on Jul 21, 2025

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
  • 37 min drive from Las Americas Premium Outlets
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,899 reviews)
"Amazing hotel clean and the pool was so nice with restaurants very good"

Reviewed on Jul 23, 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
  • 30 min drive from Las Americas Premium Outlets
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,750 reviews)
"great location"

Reviewed on Jul 21, 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
  • 29 min drive from Las Americas Premium Outlets
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,788 reviews)
"Enjoyed my stay at this place. Friendly and courteous staff"

Reviewed on Jul 21, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
  • 38 min drive from Las Americas Premium Outlets
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,582 reviews)
Perfect Staycation Hotel
"This is our 4th time staying at the Dana and we love it! Such beautiful views and even tho a bit pricey, my kids love it has 2 pools with 2 spas and movie nights! The staff are great and it’s very quiet and home feeling . We will be back in a couple of months !"

Reviewed on Jul 22, 2025

The Dana on Mission Bay
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
  • 29 min drive from Las Americas Premium Outlets
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,770 reviews)
"Great hotel, everything nice"

Reviewed on Jul 19, 2025

Marriott Marquis San Diego Marina
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
  • 31 min drive from Las Americas Premium Outlets
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.6/10 Good! (1,024 reviews)
"In a good place downtown"

Reviewed on Jul 20, 2025

The Dextro Hotel, BW Premier Collection
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4 out of 5
1 Park Blvd, San Diego, CA
  • 28 min drive from Las Americas Premium Outlets
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (1,609 reviews)
"From the moment we arrived we were welcomed. Our housekeeper was extremely helpful when we needed extra trash bags. We let her know the one we had was damaged. She fixed the problem right away. Room service was quick. I love that check out was done by text and it was quick and on point. Great ..."

Reviewed on Jul 23, 2025

Hilton San Diego Bayfront
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
  • 37 min drive from Las Americas Premium Outlets
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,853 reviews)
"Great"

Reviewed on Jul 22, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd, San Diego, CA
  • 36 min drive from Las Americas Premium Outlets
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (989 reviews)
"The hotel is super nice and pretty the only downsides are the fact that you can only access the front desk through text and the fact that the hotel gives soooo many day passes for the pool that the people staying at the hotel can never actually get a chair and it’s super crowded. We would come down ..."

Reviewed on Jul 21, 2025

Lafayette Hotel & Club
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 out of 5
2151 Hotel Circle South, San Diego, CA
  • 37 min drive from Las Americas Premium Outlets
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,140 reviews)
"Great"

Reviewed on Jul 23, 2025

Hampton Inn San Diego/Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South San Diego

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $137. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great South San Diego hotel deals at the last minute.

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Frequently Asked Questions About South San Diego hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in South San Diego?

With over 7,561 hotels in South San Diego, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $137.

How to find cheap car rentals in South San Diego?

Finding a cheap car rental deal in South San Diego is as easy as scoring cheap hotels in South San Diego. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.