Hotels Near
Otay Mesa

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Featured Otay Mesa Hotels

Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
3 out of 5
3737 Sports Arena Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
7/10 Good! (2,000 reviews)
"Every time I come, I love this hotel it’s very clean and I have trouble checking in"

Reviewed on Dec 3, 2023

Wyndham Garden San Diego Near SeaWorld
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the helpful staff ...
8/10 Very Good! (5,769 reviews)
"This hotel is clean and safe. Also bayside location is very good."

Reviewed on Dec 6, 2023

Wyndham San Diego Bayside
Paradise Point Resort & Spa
Paradise Point Resort & Spa
4 out of 5
1404 Vacation Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach resort in San Diego. Enjoy 5 outdoor pools, 3 restaurants, and a marina. Our guests praise the pool and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,895 reviews)
"I enjoyed my stay and will be visiting this property again"

Reviewed on Dec 4, 2023

Paradise Point Resort & Spa
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4 out of 5
1 Park Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy 2 bars/lounges, a full-service spa, and breakfast. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,408 reviews)
"Coming back!!! So close to everything. Very walkable. Super clean and beautiful"

Reviewed on Dec 3, 2023

Hilton San Diego Bayfront
San Diego Marriott Gaslamp Quarter
San Diego Marriott Gaslamp Quarter
4 out of 5
660 K St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy 2 bars/lounges, a nightclub, and breakfast. Our guests praise the bar and the helpful staff in ...
8.2/10 Very Good! (1,001 reviews)
"Everything was great for city"

Reviewed on Dec 5, 2023

San Diego Marriott Gaslamp Quarter
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundable
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (3,394 reviews)
"Beautiful hotel, amenities are great. Staff is amazing."

Reviewed on Dec 2, 2023

Manchester Grand Hyatt San Diego
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in San Diego. Enjoy 2 restaurants, a beach locale, and a full-service spa. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,039 reviews)
"Being so close to mission bay for morning walks and very dog friendly"

Reviewed on Dec 5, 2023

San Diego Mission Bay Resort
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy 2 outdoor pools, 4 restaurants, and a marina. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (1,930 reviews)
"Very clean, friendly staff & services, beautiful room views & great location. Who could ask for more?"

Reviewed on Nov 29, 2023

Marriott Marquis San Diego Marina
Hampton Inn San Diego-Downtown
Hampton Inn San Diego-Downtown
2.5 out of 5
San Diego
Fully refundableReserve now, pay when you stay
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,162 reviews)
"Great stay, friendly staff and perfect location"

Reviewed on Dec 4, 2023

Hampton Inn San Diego-Downtown
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (2,092 reviews)
"Good location"

Reviewed on Dec 4, 2023

Sheraton San Diego Hotel and Marina
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the restaurant and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,892 reviews)
"Very clean and close to everything"

Reviewed on Nov 28, 2023

Hard Rock Hotel San Diego
Embassy Suites by Hilton San Diego Bay Downtown
Embassy Suites by Hilton San Diego Bay Downtown
4 out of 5
601 Pacific Hwy, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in San Diego. Enjoy WiFi, room service, and a fitness center. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,295 reviews)
"Everything"

Reviewed on Dec 4, 2023

Embassy Suites by Hilton San Diego Bay Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Otay Mesa

San Diego is a city that has a lot going on, but you have your sights set on Otay Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Otay Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Otay Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Otay Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Otay Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Otay Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Otay Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $94
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Otay Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.