Hotels Near
Puerto Santa Ana

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Featured Puerto Santa Ana Hotels

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Wyndham Guayaquil Puerto Santa Ana
River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

3 out of 5
Puerto Santa Ana, Edificios Riverfront Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Stay at this apartment in Guayaquil. Enjoy free WiFi, a rooftop terrace, and a fitness center. Popular attractions Santa Ana Hill and Numa Pompilio Llona Street ...
9/10 Wonderful! (67 reviews)
"El departamento estuvo bien pero el aire acondicionado no funcionaba, estuvimos horas ahí, fue desesperante. Después nos cambiaron de departamento y ahí si funcionó súper bien todo! No hay donde dejar las maletas pero fuera de eso, bien. La dueña amable, el señor de la recepción fue honestamente ..."

Reviewed on Nov 2, 2026

River View suites Puerto Santa Ana gye
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

3.5 out of 5
Puerto Santa Ana Guayaquil Guayas
Stay at this aparthotel in Guayaquil. Enjoy free WiFi, a fitness center, and parking (surcharge). Popular attractions Santa Ana Hill and Numa Pompilio Llona ...
9.4/10 Exceptional! (112 reviews)
"The property is so secure like if it’s the White House. The check in process is terrible. If you don’t have a confirmed reservation. You can’t get inside the property not even to wait in the lobby. There’s no guess wifi downstairs either. So if your service sucks, good luck. They ask for ID’s for ..."

Reviewed on Oct 30, 2026

Luxury Suites Riverfront GYE
Edificio River Front 1 by Host Ecuador

Edificio River Front 1 by Host Ecuador

3 out of 5
Edificio River Front 1 Guayaquil Guayas
Stay at this apartment in Guayaquil. Enjoy free WiFi, a 24-hour front desk, and in-room washers/dryers. Popular attractions Santa Ana Hill and Numa Pompilio ...
Edificio River Front 1 by Host Ecuador
Hilton Colon Guayaquil

Hilton Colon Guayaquil

4.5 out of 5
Av Francisco de Orellana Mz 111 Guayaquil
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Hilton Colon Guayaquil
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
9.6/10 Exceptional! (1,005 reviews)
"Spacious clean room and a wonderful breakfast."

Reviewed on Nov 13, 2026

Oro Verde Guayaquil
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Holiday Inn Guayaquil Airport by IHG
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 out of 5
Juan Tanca Marengo Ave Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,002 reviews)
"Everything was amazing the staff the breakfast the clean rooms I really enjoyed and peaceful I will come back again and I'm going to let my friends and family the Wyndham Gardens is the best in my book"

Reviewed on Nov 12, 2026

Wyndham Garden Guayaquil
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

4 out of 5
Clemente Ballén 406 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy ...
Unipark by Oro Verde Hotels
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

4.5 out of 5
Av. Joaquín Orrantia y L. Benitez Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the breakfast and the helpful staff in our ...
TRYP by Wyndham Guayaquil Airport
Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil

3.5 out of 5
Av. Francisco De Orellana #236 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Courtyard by Marriott Guayaquil
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

5 out of 5
Av. Constitucion, Plaza del Sol Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (695 reviews)
"El parqueadero está en el último piso y a la intemperie"

Reviewed on Nov 9, 2026

Sheraton Guayaquil Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Puerto Santa Ana

Guayaquil is a city that has a lot going on, but you have your sights set on Puerto Santa Ana. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Puerto Santa Ana has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Puerto Santa Ana hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Guayaquil so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Puerto Santa Ana underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Puerto Santa Ana city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Puerto Santa Ana cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Puerto Santa Ana at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $74
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Puerto Santa Ana hotel you want, book it, and never look back. Because your great escape is ahead of you.