Hotels Near
Puerto Santa Ana

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Featured Puerto Santa Ana Hotels

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (1,007 reviews)
Yes

Reviewed on May 9, 2026

Wyndham Guayaquil Puerto Santa Ana
River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

3 out of 5
Puerto Santa Ana, Edificios Riverfront Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Stay at this apartment in Guayaquil. Enjoy free WiFi, a rooftop terrace, and a fitness center. Popular attractions Santa Ana Hill and Botanical Garden are located ...
8.8/10 Excellent! (53 reviews)
Beautiful apartment suite very safe close ally restaurant next a 24 pharmacy ac worked perfectly fine pool was beautiful and refreshing

Reviewed on Apr 23, 2026

River View suites Puerto Santa Ana gye
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

3.5 out of 5
Puerto Santa Ana Guayaquil Guayas
Stay at this aparthotel in Guayaquil. Enjoy free WiFi, a fitness center, and parking (surcharge). Popular attractions Santa Ana Hill and Botanical Garden are ...
9.4/10 Exceptional! (107 reviews)
Amazing stay. The apartment is beautiful, comfortable, and feels truly luxurious. .The location made everything even better. There’s a great market, pharmacy, and excellent restaurants just steps away. It made the whole stay very convenient, and I didn’t need to go anywhere else. Highly ...

Reviewed on Apr 16, 2026

Luxury Suites Riverfront GYE
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
9.6/10 Exceptional! (1,013 reviews)
The Oro Verde is always our choice in Guayaquil! The facility is great and the staff is world-class, amazing!

Reviewed on May 10, 2026

Oro Verde Guayaquil
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,007 reviews)
So close to the airport! Could walk there! Very clean and modern; helpful staff, loved the restaurant offerings, breakfast box was helpful (as we left at 345am to check in for a flight.)

Reviewed on May 10, 2026

Holiday Inn Guayaquil Airport by IHG
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

4 out of 5
Clemente Ballén 406 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy ...
9.2/10 Wonderful! (1,005 reviews)
Wonderful , very secure right across from the iguana park, the staff were very gentle

Reviewed on May 11, 2026

Unipark by Oro Verde Hotels
Hilton Colon Guayaquil

Hilton Colon Guayaquil

4.5 out of 5
Av Francisco de Orellana Mz 111 Guayaquil
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (909 reviews)
You are not allowed to park in front to take you bags out, the front door parking ONLY FO HOTEL’s shuttles, very stupid and they actually asked you to park down the hill. Horrible front door service, people are very rude not well trained or educated.

Reviewed on May 4, 2026

Hilton Colon Guayaquil
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 out of 5
Juan Tanca Marengo Ave Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Guayaquil. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,007 reviews)
No hay males this hotel great is the staff! They all were very helpful and cordial. My flight was cancelled and I needed a place near the airport to crash with no luggage. The guys at the front desk made sure to get me essentials like toothbrush and toothpaste, and helped me by providing me an airport ...

Reviewed on May 8, 2026

Wyndham Garden Guayaquil
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

5 out of 5
Av. Constitucion, Plaza del Sol Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (644 reviews)
Very comfortable and safe.

Reviewed on May 11, 2026

Sheraton Guayaquil Hotel
Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil

3.5 out of 5
Av. Francisco De Orellana #236 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Guayaquil. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,006 reviews)
absolutely beautiful hotel with very professional and helpful staff. Absolutely nothing to complain about. Would definitely stay there again!!!

Reviewed on May 7, 2026

Courtyard by Marriott Guayaquil
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

4.5 out of 5
Av. Joaquín Orrantia y L. Benitez Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Guayaquil. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the breakfast and the helpful staff in our ...
9/10 Wonderful! (1,003 reviews)
Muy bueno

Reviewed on May 4, 2026

TRYP by Wyndham Guayaquil Airport
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

4 out of 5
Boyaca 1615 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly hotel in Guayaquil. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (1,005 reviews)
Great place to stay

Reviewed on May 11, 2026

Grand Hotel Guayaquil, an Ascend Collection Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Puerto Santa Ana

Guayaquil is a city that has a lot going on, but you have your sights set on Puerto Santa Ana. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Puerto Santa Ana has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Puerto Santa Ana hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Guayaquil so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Puerto Santa Ana underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Puerto Santa Ana city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Puerto Santa Ana cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Puerto Santa Ana at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $74
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Puerto Santa Ana hotel you want, book it, and never look back. Because your great escape is ahead of you.