Hotels Near
Santa Ana

Photo by Isa

Check Last Minute Santa Ana Hotel Deals

Tonight Jun 1 - Jun 2Next weekend Jun 7 - Jun 9

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking, and you save up to 60%!


Featured Santa Ana Hotels

Principe Hotel and Suites
Principe Hotel and Suites
3 out of 5
Via Argentina, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,006 reviews)
"All amenities satisfied"

Reviewed on May 30, 2024

Principe Hotel and Suites
Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 3 restaurants, and 24-hour room service. Our guests praise the breakfast and the pool in our ...
9/10 Wonderful! (2,497 reviews)
"24h convenience store. It always had fresh salads and fruits."

Reviewed on May 31, 2024

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in ...
7.4/10 Good! (1,006 reviews)
"Location near the canal where you could see everyday the different ships lining up to go through the canal"

Reviewed on May 30, 2024

Dreams Playa Bonita Panama - All Inclusive
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (419 reviews)
"Nice and clean ."

Reviewed on May 29, 2024

Megapolis Hotel Panamá
Crowne Plaza Panama Airport, an IHG Hotel
Crowne Plaza Panama Airport, an IHG Hotel
4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the pool ...
8.2/10 Very Good! (1,871 reviews)
"Great staff and hotel, please fix the hot water"

Reviewed on May 31, 2024

Crowne Plaza Panama Airport, an IHG Hotel
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundable
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,006 reviews)
"We arrived, checked in and went to sleep, in the morning the floor of our room was covered in water from a leaking toilet. The front desk was very efficient, and put us in an upgraded room for the remainder of our stay. The breakfast lived up to it's reputation, it had a great selection any a large ..."

Reviewed on May 31, 2024

Decapolis Hotel Panama City
Riande Aeropuerto Hotel & Casino
Riande Aeropuerto Hotel & Casino
4 out of 5
Vía Tocumen, Entrance to Corredor Sur, Tocumen, Panama
Fully refundableReserve now, pay when you stay
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the restaurant in our ...
8.2/10 Very Good! (1,561 reviews)
"Prompt and kind attention"

Reviewed on May 30, 2024

Riande Aeropuerto Hotel & Casino
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9/10 Wonderful! (1,410 reviews)
"This is a very nice place to stay. However, there was no hot water for taking a shower. I noticed what looked like mold in the edge of the shower and there was long black strings of hair on the sink counter. I have gray hair. You have a great restaurant for meal choices. Thank you."

Reviewed on Jun 1, 2024

Plaza Paitilla Inn Hotel
Novotel Panama City
Novotel Panama City
4 out of 5
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,002 reviews)
"The amazing staff"

Reviewed on May 29, 2024

Novotel Panama City
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (878 reviews)
"It was a good stay!"

Reviewed on May 28, 2024

Las Americas Golden Tower Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
8.6/10 Excellent! (1,002 reviews)
"Property was great"

Reviewed on May 28, 2024

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (1,006 reviews)
"Good friendly and kind Good restaurant"

Reviewed on May 31, 2024

Ramada Plaza By Wyndham Panama Punta Pacífica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Ana

Panama City is a city that has a lot going on, but you have your sights set on Santa Ana. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Ana has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Ana hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Ana underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Ana city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Ana cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Ana at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $59
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Ana hotel you want, book it, and never look back. Because your great escape is ahead of you.