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Hotels in South San Francisco

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Check Last Minute South San Francisco Hotel Deals

Tonight Sep 22 - Sep 23This weekend Sep 22 - Sep 24

Last Minute Hot Rate® Hotel Deals in South San Francisco

We Hide Hotel Names So You Can Find 4-Star Hotels At 2-Star Prices. Choose the Location, Star Rating & Amenities. Let Hotwire Find You the Best Deal. Book Today!

Choose from 4973 South San Francisco Hotel Deals

Hotel Focus SFO
Hotel Focus SFO
3 out of 5
111 Mitchell Ave, South San Francisco, CA
  • 4 min walk from South San Francisco Convention Center
The price is $107 per night from Oct 22 to Oct 23
$107
per night
Oct 22 - Oct 23
Stay at this 3-star hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions The Shops at Tanforan and ...
7.4/10 Good! (1,010 reviews)
"Staff's very helpful , room big clean comfortable. Price is attractive ."

Reviewed on Sep 18, 2023

Hotel Focus SFO
DoubleTree by Hilton San Francisco South Airport Blvd
DoubleTree by Hilton San Francisco South Airport Blvd
4 out of 5
275 S Airport Blvd, South San Francisco, CA
  • 1 min walk from South San Francisco Convention Center
The price is $122 per night from Oct 15 to Oct 16
$122
per night
Oct 15 - Oct 16
Stay at this 4-star business-friendly hotel in South San Francisco. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the property condition ...
8.2/10 Very Good! (1,137 reviews)
"The hotel is fine"

Reviewed on Sep 19, 2023

DoubleTree by Hilton San Francisco South Airport Blvd
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
3 out of 5
1350 Veterans Boulevard, South San Francisco, CA
  • 4 min drive from South San Francisco Convention Center
The price is $149 per night from Sep 24 to Sep 25
$149
per night
Sep 24 - Sep 25
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions San Francisco ...
8.2/10 Very Good! (840 reviews)
"It was a good experience! Would stay again"

Reviewed on Sep 6, 2023

Sonesta ES Suites San Francisco Airport Oyster Point Waterfront
Hotel Riu Plaza Fisherman's Wharf
Hotel Riu Plaza Fisherman's Wharf
4 out of 5
2500 Mason St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $149 per night from Sep 24 to Sep 25
$149
per night
Sep 24 - Sep 25
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (5,402 reviews)
"This place was very nice. Breakfast buffet was amazing. If you go away hungry that’s your problem. Food was fresh and hot and plenty of variety. Room was clean and fresh. Location of hotel was convenient to many attractions including bus, trolley and cable cars. I would highly recommend to stay ..."

Reviewed on Sep 19, 2023

Hotel Riu Plaza Fisherman's Wharf
The Westin St. Francis San Francisco on Union Square
The Westin St. Francis San Francisco on Union Square
4.5 out of 5
335 Powell Street, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $176 per night from Oct 20 to Oct 21
$176
per night
Oct 20 - Oct 21
Stay at this 4.5-star luxury hotel in San Francisco. Enjoy breakfast, WiFi, and room service. Our guests praise the quiet rooms and the property condition in ...
8.8/10 Excellent! (2,339 reviews)
"A grand old hotel centrally located."

Reviewed on Sep 20, 2023

The Westin St. Francis San Francisco on Union Square
Hilton San Francisco Financial District
Hilton San Francisco Financial District
4 out of 5
750 Kearny St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
The price is $127 per night from Oct 1 to Oct 2
$127
per night
Oct 1 - Oct 2
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy breakfast, WiFi, and a fitness center. Our guests praise the property condition in our reviews. ...
7.6/10 Good! (3,125 reviews)
"Clean. Inexpensive compared to other hotels at this level. Like being around lots of Chinese restaurants as the food is better at that price level. Feels safe there. Can walk anywhere. The food in the hotel is not bad. Bad things, to be picky, I don’t like shower curtains. It’s a little ‘grey’ and ..."

Reviewed on Sep 21, 2023

Hilton San Francisco Financial District
Hotel Caza Fisherman's Wharf
Hotel Caza Fisherman's Wharf
4 out of 5
1300 Columbus Avenue, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $169 per night from Oct 1 to Oct 2
$169
per night
Oct 1 - Oct 2
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the bar and the convenient ...
9/10 Wonderful! (2,959 reviews)
Good room
"Our room was spacious and clean. It appeared to be new or recently renovated. The bed was comfortable. Our only complaint was various noises we could here during the night. I presume it was the commercial location. But we felt we could hear people talking more than some hotels we’ve been in."

Reviewed on Sep 20, 2023

Hotel Caza Fisherman's Wharf
Handlery Union Square Hotel
Handlery Union Square Hotel
3.5 out of 5
351 Geary St, San Francisco, CA
  • 23 min drive from South San Francisco Convention Center
The price is $189 per night from Oct 19 to Oct 20
$189
per night
Oct 19 - Oct 20
Stay at this 3.5-star business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking. Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,592 reviews)
"The hallways need better lighting. Outside my door on 5th floor, it was very dark. Not dangerous, but dark. And the bathroom door is dated and chipped. Could stand to be replaced. These are cosmetic issues. Overall my stay was pleasant and the staff very helpful and accommodating. I'd definitely ..."

Reviewed on Sep 15, 2023

Handlery Union Square Hotel
The Marina Inn on San Francisco Bay
The Marina Inn on San Francisco Bay
2.5 out of 5
68 Monarch Bay Dr, San Leandro, CA
  • 37 min drive from South San Francisco Convention Center
The price is $129 per night from Sep 24 to Sep 25
$129
per night
Sep 24 - Sep 25
Stay at this golf hotel in San Leandro. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the convenient parking and the property ...
8.6/10 Excellent! (1,643 reviews)
"Kind and friendly staff! Amenities are amazing! Love the breakfast and cookies!!!!"

Reviewed on Sep 19, 2023

The Marina Inn on San Francisco Bay
Club Quarters Hotel in San Francisco
Club Quarters Hotel in San Francisco
4 out of 5
424 Clay St, San Francisco, CA
  • 25 min drive from South San Francisco Convention Center
The price is $153 per night from Oct 20 to Oct 21
$153
per night
Oct 20 - Oct 21
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and room service. Popular attractions Pier 39 and Oracle Park are located ...
8.4/10 Very Good! (1,418 reviews)
"I would stay again, clean but water and ice was out of service"

Reviewed on Sep 17, 2023

Club Quarters Hotel in San Francisco
Holiday Inn Golden Gateway, an IHG Hotel
Holiday Inn Golden Gateway, an IHG Hotel
3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
  • 24 min drive from South San Francisco Convention Center
The price is $148 per night from Oct 1 to Oct 2
$148
per night
Oct 1 - Oct 2
Stay at this 3.5-star business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and onsite parking. Our guests praise the pool and ...
8.4/10 Very Good! (1,987 reviews)
"Muy buena experiencia"

Reviewed on Sep 19, 2023

Holiday Inn Golden Gateway, an IHG Hotel
Hyatt Centric Fisherman's Wharf San Francisco
Hyatt Centric Fisherman's Wharf San Francisco
4 out of 5
555 N Point St, San Francisco, CA
  • 27 min drive from South San Francisco Convention Center
The price is $166 per night from Oct 1 to Oct 2
$166
per night
Oct 1 - Oct 2
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the pool and the spacious ...
8.4/10 Very Good! (1,300 reviews)
"Great property, location was good located within walking distance to Pier 39 restaurants. Fog Harbor wonderful fresh seafood. The Hyatt General Manager Ryan Turner makes a point to connect with most guest almost daily. That's not something you see much of today. The Valet (George) is awesome and ..."

Reviewed on Sep 19, 2023

Hyatt Centric Fisherman's Wharf San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in South San Francisco

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your South San Francisco hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in South San Francisco.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of South San Francisco’s 4,973 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $79. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% South San Francisco hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in South San Francisco. No matter your reason for visiting South San Francisco, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About South San Francisco hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in South San Francisco for as low as $79.

How many hotels are there in South San Francisco?

With over 4,973 hotels in South San Francisco, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.

How to find cheap car rentals in South San Francisco?

Finding a cheap car rental deal in South San Francisco is as easy as scoring cheap hotels in South San Francisco. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to South San Francisco now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to South San Francisco right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.