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Featured Seneca Family Hotels
Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Seneca
Hampton Inn & Suites Seneca-Clemson Area
1011 East North 1st Street Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (662 reviews)
X
Reviewed on Nov 29, 2025
Best Western Seneca-Clemson
511 Bypass Highway 123 Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (639 reviews)
Great front desk staff!
Reviewed on Dec 7, 2025
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (720 reviews)
Good
Reviewed on Dec 6, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Seneca
Days Inn by Wyndham Seneca / Clemson Area
11015 N Radio Station Rd Seneca SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
Quality Inn Seneca Clemson Area US-123
226 Hi Tech Rd Seneca SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with a Pool in Seneca
- Apartment Hotel in Seneca
- Romantic Hotels in Seneca
- Hotels with Free Parking in Seneca
- Pet-friendly Hotels in Seneca
- Hotels with Hot Tubs in Seneca
- Hotel Wedding Venues in Seneca
- Historic Hotels in Seneca
- Resorts & Hotels with Spas in Seneca
- Hotels with smoking rooms in Seneca
Seneca Neighborhoods
Cities near Seneca
- Highlands Hotels (28.85 mi)
- Clemson Hotels (6.58 mi)
- North Carolina Mountains Hotels (75.4 mi)
- Blue Ridge Mountains Hotels (84.01 mi)
- Brevard Hotels (39.8 mi)
- Anderson Hotels (21.32 mi)
- Cashiers Hotels (30.58 mi)
- Tiger Hotels (29.4 mi)
- Clayton Hotels (28.66 mi)
- Sapphire Hotels (29.23 mi)
- Dillard Hotels (31.47 mi)
- Clarkesville Hotels (32.86 mi)
- Easley Hotels (22.2 mi)
- Toccoa Hotels (22.8 mi)
- Lake Toxaway Hotels (30.86 mi)
- Appalachian Mountains Hotels (501.81 mi)
- Hartwell Hotels (23.01 mi)
- Pickens Hotels (19.52 mi)
- Salem Hotels (14.16 mi)
- Piedmont Hotels (27.76 mi)