Search Cheap Flights to
Seneca

Photo by Cindy Keese

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Seneca Flights as Low as $107

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Fri, Sep 19 - Mon, Sep 22
BDL
Bradley Intl.
GSP
Greenville-Spartanburg Intl.
$107 Roundtrip, found 2 days ago
$107
Roundtrip
found 2 days ago
Select Breeze Airways flight, departing Fri, Sep 19 from Bradley Intl. to Greenville-Spartanburg Intl., returning Mon, Sep 22, priced at $107 found 2 days ago
Bargain Flight
Wed, Aug 6 - Mon, Aug 11
LGA
LaGuardia
GSP
Greenville-Spartanburg Intl.
$186 Roundtrip, found 6 hours ago
$186
Roundtrip
found 6 hours ago
Select Bargain Flight flight, departing Wed, Aug 6 from LaGuardia to Greenville-Spartanburg Intl., returning Mon, Aug 11, priced at $186 found 6 hours ago
Delta
Thu, Aug 14 - Wed, Aug 20
LGA
LaGuardia
GSP
Greenville-Spartanburg Intl.
$197 Roundtrip, found 2 hours ago
$197
Roundtrip
found 2 hours ago
Select Delta flight, departing Thu, Aug 14 from LaGuardia to Greenville-Spartanburg Intl., returning Wed, Aug 20, priced at $197 found 2 hours ago
American Airlines
Wed, Aug 6 - Mon, Aug 11
LGA
LaGuardia
GSP
Greenville-Spartanburg Intl.
$201 Roundtrip, found 6 hours ago
$201
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Aug 6 from LaGuardia to Greenville-Spartanburg Intl., returning Mon, Aug 11, priced at $201 found 6 hours ago
United
Tue, Aug 26 - Wed, Aug 27
DEN
Denver Intl.
GSP
Greenville-Spartanburg Intl.
$217 Roundtrip, found 2 days ago
$217
Roundtrip
found 2 days ago
Select United flight, departing Tue, Aug 26 from Denver Intl. to Greenville-Spartanburg Intl., returning Wed, Aug 27, priced at $217 found 2 days ago
Bargain Flight
Tue, Jun 17 - Tue, Jun 24
ROC
Greater Rochester Intl.
GSP
Greenville-Spartanburg Intl.
$238 Roundtrip, found 1 day ago
$238
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 17 from Greater Rochester Intl. to Greenville-Spartanburg Intl., returning Tue, Jun 24, priced at $238 found 1 day ago
Delta
Wed, Jul 16 - Sat, Jul 19
VPS
Northwest Florida Regional
GSP
Greenville-Spartanburg Intl.
$251 Roundtrip, found 1 day ago
$251
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Jul 16 from Northwest Florida Regional to Greenville-Spartanburg Intl., returning Sat, Jul 19, priced at $251 found 1 day ago
Bargain Flight
Wed, Jul 9 - Wed, Jul 16
DTW
Detroit Metropolitan Wayne County
GSP
Greenville-Spartanburg Intl.
$255 Roundtrip, found 4 days ago
$255
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Wed, Jul 9 from Detroit Metropolitan Wayne County to Greenville-Spartanburg Intl., returning Wed, Jul 16, priced at $255 found 4 days ago
Bargain Flight
Mon, Oct 6 - Tue, Oct 21
SEA
Seattle - Tacoma Intl.
GSP
Greenville-Spartanburg Intl.
$269 Roundtrip, found 1 day ago
$269
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Mon, Oct 6 from Seattle - Tacoma Intl. to Greenville-Spartanburg Intl., returning Tue, Oct 21, priced at $269 found 1 day ago
Bargain Flight
Sat, Aug 30 - Wed, Sep 3
SMF
Sacramento Intl.
GSP
Greenville-Spartanburg Intl.
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Aug 30 from Sacramento Intl. to Greenville-Spartanburg Intl., returning Wed, Sep 3, priced at $274 found 1 day ago
Delta
Tue, Jul 1 - Wed, Jul 2
STL
Lambert-St. Louis Intl.
GSP
Greenville-Spartanburg Intl.
$292 Roundtrip, found 1 day ago
$292
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 1 from Lambert-St. Louis Intl. to Greenville-Spartanburg Intl., returning Wed, Jul 2, priced at $292 found 1 day ago
Bargain Flight
Thu, Jun 26 - Wed, Jul 2
ABQ
Albuquerque Intl. Sunport
GSP
Greenville-Spartanburg Intl.
$297 Roundtrip, found 3 hours ago
$297
Roundtrip
found 3 hours ago
Select Bargain Flight flight, departing Thu, Jun 26 from Albuquerque Intl. Sunport to Greenville-Spartanburg Intl., returning Wed, Jul 2, priced at $297 found 3 hours ago
Bargain Flight
Tue, Jun 17 - Wed, Jun 18
ATL
Hartsfield-Jackson Atlanta Intl.
GSP
Greenville-Spartanburg Intl.
$377 Roundtrip, found 1 day ago
$377
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 17 from Hartsfield-Jackson Atlanta Intl. to Greenville-Spartanburg Intl., returning Wed, Jun 18, priced at $377 found 1 day ago
Delta
Mon, Jun 16 - Wed, Jun 25
JAX
Jacksonville Intl.
GSP
Greenville-Spartanburg Intl.
$473 Roundtrip, found 6 days ago
$473
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Jun 16 from Jacksonville Intl. to Greenville-Spartanburg Intl., returning Wed, Jun 25, priced at $473 found 6 days ago
American Airlines
Tue, Jun 17 - Wed, Jun 18
BNA
Nashville Intl.
GSP
Greenville-Spartanburg Intl.
$486 Roundtrip, found 2 days ago
$486
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Jun 17 from Nashville Intl. to Greenville-Spartanburg Intl., returning Wed, Jun 18, priced at $486 found 2 days ago
United
Tue, Jun 17 - Tue, Jun 24
IAH
George Bush Intercontinental
GSP
Greenville-Spartanburg Intl.
$820 Roundtrip, found 2 days ago
$820
Roundtrip
found 2 days ago
Select United flight, departing Tue, Jun 17 from George Bush Intercontinental to Greenville-Spartanburg Intl., returning Tue, Jun 24, priced at $820 found 2 days ago

Cheap Flights to Seneca

Fall in love at first flight with your vacation to Seneca by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Seneca on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Seneca, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Seneca

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Seneca with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the GSP airport.

What is the cheapest month to fly to Seneca?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Seneca are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Seneca?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 9 to choose from for your flight to Seneca.

What airport is best to fly into Seneca?

When you’re planning your trip to Seneca, convenience is the name of the game. Luckily, Seneca Greenville-Spartanburg Intl. Airport is nearby so you can deplane and get going on checking off everything on your Seneca must-do list.

How much are flights to Seneca?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Seneca on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $107, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Seneca?

The trick to saving a stack of cash on your flight to Seneca? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $107 right now, why wait?

Seneca Flight Information
Destination airport
Greenville-Spartanburg Intl.
Destination airport IATA code
GSP
Roundtrip price
$106

Last Minute Hotel Deals in Seneca

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (896 reviews)
"It was on the lake, rooms were nice. Plenty of parking."

Reviewed on Jun 12, 2025

Get rates
Lakeside Lodge Clemson
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (601 reviews)
"Clean comfortable room in a good location with a nice breakfast and a friendly staff. Checks all the boxes!"

Reviewed on Jun 2, 2025

Get rates
Hampton Inn & Suites Seneca-Clemson Area
Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (597 reviews)
"Really good place"

Reviewed on Jun 13, 2025

Get rates
Quality Inn Seneca Clemson Area US-123
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (721 reviews)
"Great place to stay, Hannah at the front desk was fabulous!"

Reviewed on Jun 2, 2025

Get rates
Tru by Hilton Seneca Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (157 reviews)
"The staff were very friendly and they included breakfast had a good variety."

Reviewed on Jun 8, 2025

Get rates
Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (683 reviews)
"Clean and comfortable. Good location. Close to Clemson University"

Reviewed on May 9, 2025

Get rates
Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Best Western Seneca-Clemson
2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (590 reviews)
Lb
"Room was very clean. Easy to get to room. They pickup the trash and gave us clean linens while we were gone didnt notice they were there. The only thing that was disapointing was the pool was closed"

Reviewed on May 27, 2025

Get rates
Best Western Seneca-Clemson
Postcard Cabins Lake Hartwell
Postcard Cabins Lake Hartwell
2 out of 5
299 Outpost Rd, Seneca, SC
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
10/10 Exceptional! (7 reviews)
"great getaway. comfortable accommodations"

Reviewed on May 16, 2025

Get rates
Postcard Cabins Lake Hartwell
See all 1,555 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.