Search for Cheap Deals on
Hotels in Salem

Check Last Minute Salem Hotel Deals

Tonight Apr 12 - Apr 13Next weekend Apr 17 - Apr 19

Choose from 3226 Salem Hotel Deals

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
  • 24 min drive from Lake Keowee
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,005 reviews)
Quite a decent breakfast, including the fresh yogurt dispensing machine. The yogurt was very good and the topping choices were decent. Would have preferred fresh berries as an option for my yogurt parfait. The front desk staff (one person) was awful. She was cold and unhelpful.

Reviewed on Apr 12, 2026

Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
  • 24 min drive from Lake Keowee
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9.8/10 Exceptional! (784 reviews)
hotel was great, modern, clean gorgeous

Reviewed on Apr 7, 2026

The Shepherd Hotel Downtown Clemson
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
  • 21 min drive from Lake Keowee
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (1,011 reviews)
This place is tops! The area is great, rooms were wonderful, and amenities were amazing. Definitely plan on staying again asap!

Reviewed on Apr 9, 2026

Lakeside Lodge Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
  • 34 min drive from Lake Keowee
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (68 reviews)
Great spot for couples wanting to connect or a solo trip.

Reviewed on Apr 2, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

3 out of 5
240 Madren Center Drive Clemson SC
  • 26 min drive from Lake Keowee
Book a stay at this golf hotel in Clemson. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (1,006 reviews)
This seems to be one of the only hotels in clemson near the school. We came here to tour the school and stay a night. I was excited to use the pool and relax a bit as well. Unfortunately when we checked in - the young gentleman at the front desk basically had his airpods in and gave us our keys with ...

Reviewed on Apr 12, 2026

Clemson University's James F. Martin Inn
The Inn at Patrick Square

The Inn at Patrick Square

3.5 out of 5
115 Market Street Clemson SC
  • 28 min drive from Lake Keowee
Book a stay at this business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9.8/10 Exceptional! (830 reviews)
Nice room. Quiet location

Reviewed on Apr 11, 2026

The Inn at Patrick Square
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
  • 24 min drive from Lake Keowee
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,005 reviews)
Very clean comfortable. Good design for long stays thanks

Reviewed on Apr 11, 2026

Comfort Inn & Suites Clemson - University Area
The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy Clemson SC
  • 24 min drive from Lake Keowee
Book a stay at this business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.6/10 Exceptional! (587 reviews)
I wanted to get coffee upon waking up in the morning. I went down in the morning and ther person behind the counter told me she needed to finish counting the drawer before she could help me. So I needed to wait there about 10-15 mins until the drawer was counted. Seems like the customer should be ...

Reviewed on Apr 6, 2026

The Abernathy of Clemson
Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy

4 out of 5
96 Log Cabin Lane Highlands NC
  • 1 hour drive from Lake Keowee
Stay at this hotel in Highlands. Enjoy free parking, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (289 reviews)
Great location, quiet, easy in and out. Didn’t bring our pet but would have been perfect!

Reviewed on Apr 8, 2026

Trailborn Highlands, Outdoor Collection by Marriott Bonvoy
Highlander Mountain House

Highlander Mountain House

3.5 out of 5
270 Main Street Highlands NC
  • 1 hour drive from Lake Keowee
Stay at this inn in Highlands. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (227 reviews)
Cute room with very friendly staff!

Reviewed on Apr 8, 2026

Highlander Mountain House
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street Seneca SC
  • 20 min drive from Lake Keowee
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (692 reviews)
Only 7 miles from Clemson. Quiet and enjoyable place to stay!

Reviewed on Apr 7, 2026

Hampton Inn & Suites Seneca-Clemson Area
Comfort Inn & Suites Brevard North

Comfort Inn & Suites Brevard North

2.5 out of 5
2228 Asheville Hwy Brevard NC
  • 1 hour drive from Lake Keowee
Stay at this hotel in Brevard. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (1,008 reviews)
Breakfast was fine. Everything was clean and well organized. Staff was friendly and helpful

Reviewed on Apr 12, 2026

Comfort Inn & Suites Brevard North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Salem

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Salem hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Salem.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Salem’s 3,226 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $110. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Salem hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Salem. No matter your reason for visiting Salem, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Salem hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Salem for as low as $110.

How many hotels are there in Salem?

With over 3,226 hotels in Salem, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $110.

How to find cheap car rentals in Salem?

Finding a cheap car rental deal in Salem is as easy as scoring cheap hotels in Salem. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.