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Hotels in Seneca

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Check Last Minute Seneca Hotel Deals

Tonight Jul 27 - Jul 28Next weekend Aug 2 - Aug 4

Choose from 1499 Seneca Hotel Deals

Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $134 per night from Jul 28 to Jul 29
$134
includes taxes & fees
Jul 28 - Jul 29
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the property condition in our reviews. Popular attractions ...
8.8/10 Excellent! (668 reviews)
"Nice place to stay."

Reviewed on Jul 25, 2024

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
The price is $118 per night from Aug 25 to Aug 26
$118
includes taxes & fees
Aug 25 - Aug 26
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Littlejohn Coliseum and Memorial ...
9.2/10 Wonderful! (602 reviews)
"This property was very clean and felt kept. We were very comfortable. Would definitely book again."

Reviewed on Jul 23, 2024

Tru by Hilton Seneca Clemson
Quality Inn Seneca US-123
Quality Inn Seneca US-123
2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $98 per night from Aug 4 to Aug 5
$98
includes taxes & fees
Aug 4 - Aug 5
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. Popular ...
7.8/10 Good! (499 reviews)
"I was pleasantly surprised when I entered my room. It was exactly all that we needed no more no less. The property, the rooms, the dining room everything about it was very clean and neat. The beds were very comfortable, hot water immediately, and wonderful water pressure. This staff was very friendly ..."

Reviewed on Jul 23, 2024

Quality Inn Seneca US-123
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
The price is $139 per night from Jul 29 to Jul 30
$139
includes taxes & fees
Jul 29 - Jul 30
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Keowee Reservoir and Littlejohn ...
9.2/10 Wonderful! (539 reviews)
"The property was clean and well kept! Staff was professional and friendly. Keep up the good work! This is my third stay and will probably book again in the future."

Reviewed on Jul 17, 2024

Hampton Inn & Suites Seneca-Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2 out of 5
11015 N Radio Station Rd, Seneca, SC
  • 14 min drive from Keowee Reservoir
The price is $77 per night from Aug 4 to Aug 5
$77
includes taxes & fees
Aug 4 - Aug 5
Book a stay at this business-friendly motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (617 reviews)
"Basic & Reasonable"

Reviewed on Jun 16, 2024

Days Inn by Wyndham Seneca / Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC
  • 10 min drive from Keowee Reservoir
The price is $142 per night from Jul 28 to Jul 29
$142
includes taxes & fees
Jul 28 - Jul 29
Book a stay at this business-friendly hotel in Seneca. Enjoy free parking, a fitness center, and a 24-hour front desk. Popular attraction Keowee Reservoir is ...
9.4/10 Exceptional! (109 reviews)
"Very close (walking distance) to two restaurants and the Dollar General. Lovely view of lake Keowee from our window."

Reviewed on Jul 21, 2024

Fairfield Inn & Suites Seneca Clemson Univ Area
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $103 per night from Aug 4 to Aug 5
$103
includes taxes & fees
Aug 4 - Aug 5
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Clemson Area African American ...
8.2/10 Very Good! (823 reviews)
Super stay.
"Best Western super as always."

Reviewed on Jul 21, 2024

Best Western Plus Clemson Hotel & Conference Center
Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
  • 43 min drive from Keowee Reservoir
The price is $64 per night from Aug 11 to Aug 12
$64
includes taxes & fees
Aug 11 - Aug 12
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Anderson Mall and NewSpring Church ...
7/10 Good! (779 reviews)
"This property has the best service and fast communication. I love staying here. Jennifer & Trinity are the best ever I love their hospitality and they always make sure every customer is took care of not just me. Thanks to them and all they do."

Reviewed on Jul 23, 2024

Days Inn by Wyndham Anderson
Inn @ Clemson
Inn @ Clemson
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $110 per night from Jul 28 to Jul 29
$110
includes taxes & fees
Jul 28 - Jul 29
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy ...
8/10 Very Good! (1,003 reviews)
"Wonderful staff, rooms clean"

Reviewed on Jul 21, 2024

Inn @ Clemson
The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown Clemson
4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
The price is $188 per night from Jul 28 to Jul 29
$188
includes taxes & fees
Jul 28 - Jul 29
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the property condition in our ...
9.6/10 Exceptional! (336 reviews)
"LOVED this hotel!"

Reviewed on Jul 24, 2024

The Shepherd Hotel Downtown Clemson
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
The price is $99 per night from Jul 28 to Jul 29
$99
includes taxes & fees
Jul 28 - Jul 29
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Popular attractions Clemson Area African American ...
8/10 Very Good! (1,001 reviews)
Great stay in the upstate!
"This hotel has been remodeled and it is beautiful. The staff is nice and helpful. I would stay there again. Did I mention the nice lady who prepares the southern biscuits and gravy? It was a wonderful four days in Clemson while our grandson was at the Clemson Baseball Camp."

Reviewed on Jul 12, 2024

Comfort Inn & Suites Clemson - University Area
Hampton Inn Clemson-University Area
Hampton Inn Clemson-University Area
2.5 out of 5
851 Tiger Blvd, Clemson, SC
  • 12 min drive from Keowee Reservoir
The price is $122 per night from Aug 2 to Aug 3
$122
includes taxes & fees
Aug 2 - Aug 3
Stay at this hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Larry W. Abernathy Waterfront Park and Littlejohn Coliseum ...
8.8/10 Excellent! (538 reviews)
"Clean"

Reviewed on Jul 20, 2024

Hampton Inn Clemson-University Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Seneca

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Seneca hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,499 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Seneca for as low as $64.

How many hotels are there in Seneca?

With over 1,499 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Seneca now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Seneca right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.