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Hotels in Seneca

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Choose from 1592 Seneca Hotel Deals

Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
9/10 Wonderful! (941 reviews)
"Staff were great."

Reviewed on Jul 13, 2025

Lakeside Lodge Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (172 reviews)
"Liked the view of the lake and the large breakfast area. Breakfast was excellent."

Reviewed on Jul 11, 2025

Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
  • 7 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (608 reviews)
"convenient to our needs"

Reviewed on Jun 30, 2025

Hampton Inn & Suites Seneca-Clemson Area
Postcard Cabins Lake Hartwell

Postcard Cabins Lake Hartwell

2 out of 5
299 Outpost Rd, Seneca, SC
  • 20 min drive from Keowee Reservoir
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (11 reviews)
"Loved the space and simplicity"

Reviewed on Jul 12, 2025

Postcard Cabins Lake Hartwell
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
  • 11 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (736 reviews)
"Excellent location and superior welcoming staff"

Reviewed on Jul 14, 2025

Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (607 reviews)
"I am very clean staff very, very friendly good location"

Reviewed on Jun 22, 2025

Quality Inn Seneca Clemson Area US-123
Best Western Seneca-Clemson

Best Western Seneca-Clemson

2.5 out of 5
511 Bypass Highway 123, Seneca, SC
  • 8 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (593 reviews)
"Showers not safe for senior citizens."

Reviewed on Jul 13, 2025

Best Western Seneca-Clemson
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
  • 43 min drive from Keowee Reservoir
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,014 reviews)
"Great stay"

Reviewed on Jul 12, 2025

Days Inn by Wyndham Anderson
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
  • 15 min drive from Keowee Reservoir
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our ...
9.6/10 Exceptional! (624 reviews)
"We had an amazing stay. From the beautifully decorated, relaxing room, to the restaurant decor and excellent service and food, to the cute coffee stations on each floor, to the bar and deck, it was all fantastic!"

Reviewed on Jul 14, 2025

The Shepherd Hotel Downtown Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,004 reviews)
Family
"Family reunion"

Reviewed on Jul 9, 2025

Comfort Inn & Suites Clemson - University Area
Horizon Inn & Suites

Horizon Inn & Suites

2 out of 5
3025 N Main Street, Anderson, SC
  • 52 min drive from Keowee Reservoir
Stay at this hotel in Anderson. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Anderson Mall and North Anderson Park are located ...
4.8/10 (180 reviews)
"Quiet stay, rooms are clean, everyone is nice"

Reviewed on Jun 30, 2025

Horizon Inn & Suites
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free parking, an outdoor pool, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,000 reviews)
"The staff was incredibly friendly and professional the room was huge and the proximity to CVS, gas station and many restaurants was an added bonus"

Reviewed on Jun 30, 2025

Best Western Plus Clemson Hotel & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,592 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Seneca?

With over 1,592 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.