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Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd Seneca SC
  • 11 min drive from Keowee Reservoir
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (1,005 reviews)
We booked this hotel because the hot tub is open during the winter. Our 1 BR suite was large and in excellent condition. We did not try the restaurant but heard good things about it. Some reviews we have seen complained about train noises. Apparently, they have resolved that issue - didn't hear a ...

Reviewed on Jan 19, 2026

Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd Seneca SC
  • 11 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (803 reviews)
The staff here are top tier! We had to be at a meet at the university by 6am and they made breakfast early so our kids could eat before the meet! Genuine care for their guest! Love it here!

Reviewed on Jan 11, 2026

Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

2 out of 5
299 Outpost Rd Seneca SC
  • 20 min drive from Keowee Reservoir
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreaction Area and Cross Creek Plantation Golf ...
9.6/10 Exceptional! (55 reviews)
Yes so comfortable

Reviewed on Jan 18, 2026

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd Seneca SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (670 reviews)
Our stay was very nice. Clean room. The outside was clean.

Reviewed on Jan 20, 2026

Quality Inn Seneca Clemson Area US-123
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street Seneca SC
  • 7 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (673 reviews)
The room and more spacious than we anticipated. The property and room was very clean. We had a king size bed with standard pillows. The pillows were flat and uncomfortable. The daily breakfast items were not hot.

Reviewed on Jan 22, 2026

Hampton Inn & Suites Seneca-Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123 Seneca SC
  • 10 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (206 reviews)
Spotless, friendly staff, great location.

Reviewed on Jan 14, 2026

Fairfield Inn & Suites Seneca Clemson Univ Area
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd Seneca SC
  • 14 min drive from Keowee Reservoir
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
6.8/10 (724 reviews)
Good

Reviewed on Dec 6, 2025

Days Inn by Wyndham Seneca / Clemson Area
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
  • 15 min drive from Keowee Reservoir
Stay at this hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
9.8/10 Exceptional! (752 reviews)
Would definitely stay here again. Was an amazing hotel.

Reviewed on Jan 21, 2026

The Shepherd Hotel Downtown Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,000 reviews)
Rooms are clean. Staff was very pleasant.

Reviewed on Jan 20, 2026

Best Western Plus Clemson Hotel & Conference Center
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
  • 16 min drive from Keowee Reservoir
Stay at this cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park are ...
Wooded Cottage - 3 Mi to Clemson University
Quality Inn & Suites Easley - Greenville

Quality Inn & Suites Easley - Greenville

2.5 out of 5
5539 Calhoun Memorial Hwy Easley SC
  • 59 min drive from Keowee Reservoir
Stay at this hotel in Easley. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Easley Recreation Center and Dollar Tree Plaza are located ...
6.8/10 (393 reviews)
The staff was pleasant and facility was clean.

Reviewed on Jan 12, 2026

Quality Inn & Suites Easley - Greenville
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd Clemson SC
  • 16 min drive from Keowee Reservoir
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,000 reviews)
Clean room. Friendly staff. Convenient location.

Reviewed on Jan 17, 2026

Comfort Inn & Suites Clemson - University Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Seneca

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Seneca.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Seneca’s 1,624 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $58. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Seneca hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Seneca. No matter your reason for visiting Seneca, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Seneca hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Seneca for as low as $58.

How many hotels are there in Seneca?

With over 1,624 hotels in Seneca, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $58.

How to find cheap car rentals in Seneca?

Finding a cheap car rental deal in Seneca is as easy as scoring cheap hotels in Seneca. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.