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Hotels in Central San Diego

Choose from 1589 Central San Diego Hotel Deals

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,181 reviews)
Room was clean and functional.

Reviewed on Jan 31, 2026

Best Western Seven Seas
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr La Jolla CA
  • 23 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.4/10 Very Good! (2,250 reviews)
it was nice and the staff were genuine and warm

Reviewed on Jan 27, 2026

San Diego Marriott La Jolla
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
7.8/10 Good! (2,448 reviews)
Great

Reviewed on Jan 29, 2026

Days Inn by Wyndham San Diego Hotel Circle
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
  • 5 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,311 reviews)
Staff was helpful

Reviewed on Jan 31, 2026

Hilton San Diego Mission Valley
Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla

4 out of 5
4550 La Jolla Village Dr San Diego CA
  • 23 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, 2 restaurants, and a free beach shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,849 reviews)
adequate breakfast

Reviewed on Jan 28, 2026

Embassy Suites by Hilton San Diego La Jolla
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
  • 26 min walk from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,449 reviews)
Unique place to stay

Reviewed on Jan 28, 2026

Lafayette Hotel & Club
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
  • 6 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.2/10 Very Good! (1,512 reviews)
Clean and great staff

Reviewed on Feb 1, 2026

DoubleTree by Hilton Hotel San Diego - Mission Valley
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
9/10 Wonderful! (2,941 reviews)
We had an amazing stay at Legacy Resort Spa. From the moment we arrived, the staff made us feel genuinely welcome—everyone was kind, attentive, and professional. A special shout-out to Nick at the front desk, who was absolutely wonderful and went above and beyond to make our stay seamless. The gym ...

Reviewed on Jan 30, 2026

Legacy Resort Hotel & Spa
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
  • 4 min drive from San Diego Zoo
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,625 reviews)
Staff was wonderful! Room was very clean with daily housekeeping (which is rarely seen these days). The restaurants were very good too. Totally recommend this nice little Motel.

Reviewed on Feb 3, 2026

Kings Inn San Diego
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
  • 17 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
7.6/10 Good! (2,299 reviews)
Was amazing loved it everyone ones professional and very helpful

Reviewed on Feb 1, 2026

California Suites Hotel
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (2,299 reviews)
They took my concerns seriously, prioritized my safety, and made sure I felt heard and supported. The manager was professional, responsive, and worked to resolve my concerns. I truly appreciate the way everything was handled and the care shown by the staff during a stressful experience.

Reviewed on Jan 28, 2026

Handlery Hotel
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area

3 out of 5
4200 Taylor St San Diego CA
  • 4 min drive from San Diego Zoo
Stay at this hotel in San Diego. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.6/10 Excellent! (1,329 reviews)
Great location, great price, nice hotel

Reviewed on Jan 30, 2026

Hilton Garden Inn San Diego Old Town/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central San Diego

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central San Diego.

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $87. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central San Diego hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central San Diego. No matter your reason for visiting Central San Diego, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central San Diego hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Central San Diego for as low as $87.

How many hotels are there in Central San Diego?

With over 1,589 hotels in Central San Diego, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.

How to find cheap car rentals in Central San Diego?

Finding a cheap car rental deal in Central San Diego is as easy as scoring cheap hotels in Central San Diego. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.