Search for Cheap Deals on
Hotels in Florence

Choose from 325 Florence Hotel Deals

Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence
2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,211 reviews)
"Very nice hotel. Front staff was friendly and helpful. Made a great dinner recommendation. Room was big and clean. Nothing fancy just a good place to stay for a one night stop over."

Reviewed on May 26, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC
2.5 out of 5
1729 Mandeville Road, Florence, SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,048 reviews)
"It was dog friendly and very clean. The staff was very friendly and helpful!"

Reviewed on May 24, 2025

Park Inn by Radisson Florence, SC
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,211 reviews)
"Very comfortable"

Reviewed on May 25, 2025

Quality Inn & Suites Florence Civic Center
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
  • 3 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,006 reviews)
Great Stay Great Price
"The room was perfect. It was clean, quiet, and nicely decorated."

Reviewed on May 26, 2025

Comfort Inn & Suites
Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3 out of 5
100 East Evans Street Florence, Florence, SC
  • 11 min drive from Florence Civic Center
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,001 reviews)
"Staff was outstanding"

Reviewed on May 23, 2025

Hyatt Place Florence Downtown
La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence
3 out of 5
2123 W Lucas St, Florence, SC
  • 10 min drive from Florence Civic Center
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,641 reviews)
"Nice hotel could use some upgrades beginning to show wear and tear."

Reviewed on May 21, 2025

La Quinta Inn & Suites by Wyndham Florence
Microtel Inn & Suites by Wyndham Florence
Microtel Inn & Suites by Wyndham Florence
2 out of 5
1912 Enterprise Dr, Florence, SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.6/10 (1,001 reviews)
"Check in employee was great."

Reviewed on May 24, 2025

Microtel Inn & Suites by Wyndham Florence
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
  • 8 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,007 reviews)
"Quiet and clean"

Reviewed on May 26, 2025

Days Inn by Wyndham Florence Near Civic Center
Sleep Inn Florence North
Sleep Inn Florence North
2.5 out of 5
1833 Florence Park Dr, Florence, SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (616 reviews)
"Great for a overnight"

Reviewed on May 14, 2025

Sleep Inn Florence North
Tru by Hilton Florence I-95
Tru by Hilton Florence I-95
2.5 out of 5
2140 West Lucas Street, Florence, SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
"Easy check-in comfortable beds"

Reviewed on May 23, 2025

Tru by Hilton Florence I-95
Country Inn & Suites by Radisson, Florence, SC
Country Inn & Suites by Radisson, Florence, SC
2.5 out of 5
1739 Mandeville Rd, Florence, SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,008 reviews)
"Very convenient for a ball travel team. Clean and safe"

Reviewed on May 20, 2025

Country Inn & Suites by Radisson, Florence, SC
Days Inn by Wyndham Florence/I-95 North
Days Inn by Wyndham Florence/I-95 North
2 out of 5
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,005 reviews)
"Love the bed and sheets"

Reviewed on May 26, 2025

Days Inn by Wyndham Florence/I-95 North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Florence

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Florence hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Florence.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Florence’s 325 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Florence hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Florence. No matter your reason for visiting Florence, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Florence hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Florence for as low as $62.

How many hotels are there in Florence?

With over 325 hotels in Florence, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.

How to find cheap car rentals in Florence?

Finding a cheap car rental deal in Florence is as easy as scoring cheap hotels in Florence. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.