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Featured Florence Family Hotels

Home2 Suites by Hilton Florence, SC
900 Woody Jones Blvd Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr Florence SC
Fully refundable
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Fairfield Inn by Marriott Hartsville
200 S 4th St Hartsville SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Days Inn by Wyndham Dillon
823 Radford Blvd Dillon SC
Stay at this hotel in Dillon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...

Quality Inn & Suites Florence Civic Center
150 Dunbarton Dr Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

La Quinta Inn & Suites by Wyndham Florence
2123 W Lucas St Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Hotel Florence, Tapestry Collection by Hilton
126 W Evans St Florence SC
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...

The Landmark Inn
1301 South 4th Street Hartsville SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Comfort Suites Florence I-95
2120 West Lucas Street Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Florence

Spark by Hilton Florence North I-95, SC
1739 Mandeville Rd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (34 reviews)
Estuvimos en Spark by Hilton Florence North I-95 de paso y fue una experiencia aceptable. La ubicación es muy conveniente justo saliendo de la I-95, el desayuno continental estaba incluido y la habitación era cómoda. Aceptan mascotas con cargo adicional, lo cual fue perfecto para nuestro perrito ...
Reviewed on Jan 4, 2026

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
2101 Florence Harllee Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,009 reviews)
Hotel is right off the highway, close to Buc-ee’s and the room was very spacious. Breakfast was fine with your standard staples. Front desk staff were very friendly and helpful.
Reviewed on Jan 2, 2026

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
3440 W Radio Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,002 reviews)
Excellent service and room were much better than RedRoof inn. Highly recommend it!!!
Reviewed on Dec 31, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Florence

Comfort Suites Florence I-95
2120 West Lucas Street Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Days Inn by Wyndham Florence/I-95 North
2111 West Lucas St/I-95 Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Days Inn by Wyndham Florence Near Civic Center
140 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Florence
- Hotels with a Pool in Florence
- Pet-friendly Hotels in Florence
- Beach Hotels in Florence
- Hotels with an Indoor Pool in Florence
- Luxury Hotels in Florence
- Hotels with Hot Tubs in Florence
- Resorts & Hotels with Spas in Florence
- Apartment Hotel in Florence
- Hotels with smoking rooms in Florence
Other Accommodation Types
Top Points of Interests in Florence
- Hotels near Florence Civic Center
- Hotels near Magnolia Mall
- Hotels near Francis Marion University
- Hotels near Mcleod Regional Medical Center
- Hotels near Eastern Carolina Agricultural Fairgrounds
- Hotels near Florence Museum
- Hotels near Florence National Cemetery
- Hotels near The Traces Golf Club
- Hotels near Oakdale Country Club
- Hotels near Florence Veterans Park
- Hotels near Columns Plantation
Cities near Florence
- Hartsville Hotels (21.27 mi)
- Dillon Hotels (27.21 mi)
- Southeastern United States Hotels (264.9 mi)
- The Carolinas Hotels (50.37 mi)
- Latta Hotels (21.48 mi)
- Darlington Hotels (9.59 mi)
- Lake City Hotels (22.42 mi)
- Cheraw Hotels (35.17 mi)
- Marion Hotels (21.04 mi)
- Hemingway Hotels (35.7 mi)
- Bennettsville Hotels (29.4 mi)
- Hamer Hotels (31.63 mi)
- Mullins Hotels (29.34 mi)
- Bishopville Hotels (27.46 mi)
- Timmonsville Hotels (10.89 mi)
- Aynor Hotels (35.18 mi)
- Sellers Hotels (17.89 mi)
- Lynchburg Hotels (19.91 mi)
- The South Hotels (584.78 mi)
- Turbeville Hotels (25.46 mi)
