Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florence Vacations

Pack those stellar shades. We have Florence vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Florence – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Florence vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Florence

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Florence vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Florence well.

Top Hotel Deals

See all 109 Hotels in Florence
Baymont Inn & Suites Florence by Wyndham

Baymont Inn & Suites Florence by Wyndham

1826 W Lucas Street, Florence
    2.0 out of 5.0
     
     

    Situated in Florence, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Florence Museum, and Florence Civic Center. Magnolia Mall and Darlington ...

    Baymont Inn & Suites Florence by Wyndham$52

    Baymont Inn & Suites Florence by Wyndham$52
    Red Roof Inn Florence - Civic Center

    Red Roof Inn Florence - Civic Center

    2690 David H McLeod Boulevard, Florence
      2.0 out of 5.0
       
       

      Situated near the airport, this hotel is within a 10-minute walk of Magnolia Mall and Florence Civic Center. Florence Museum and Mcleod Regional Medical Center ...

      Red Roof Inn Florence - Civic Center$58

      Red Roof Inn Florence - Civic Center$58
      Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327

      Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327

      2101 Florence Harllee Blvd, Florence
        2.5 out of 5.0
         
         

        Situated in Florence, this hotel is within 9 mi (15 km) of Francis Marion University, Eastern Carolina Agricultural Fairgrounds, and Florence Museum. Mcleod ...

        Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327$119

        Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327$119
        Ramada by Wyndham Florence Center

        Ramada by Wyndham Florence Center

        1819 West Lucas Street, Florence
           
           

          Situated in Florence, this hotel is within 6 mi (10 km) of Florence Museum, Mcleod Regional Medical Center, and Florence Civic Center. Magnolia Mall and Darlington ...

          Ramada by Wyndham Florence Center$67

          Ramada by Wyndham Florence Center$67
          Quality Inn And Suites Civic

          Quality Inn And Suites Civic

          150 Dunbarton Dr, Florence
            2.5 out of 5.0
             
             

            Located in the heart of Florence, this hotel is within a 15-minute walk of Magnolia Mall and Florence Civic Center. Florence Museum and Mcleod Regional Medical ...

            Quality Inn And Suites Civic$100

            Quality Inn And Suites Civic$100
            Days Inn by Wyndham Florence/I-95 North

            Days Inn by Wyndham Florence/I-95 North

            2111 West Lucas St/I-95, Florence
              2.0 out of 5.0
               
               

              Situated in Florence, this motel is within 6 mi (10 km) of Mcleod Regional Medical Center, Florence Museum, and Magnolia Mall. Florence Civic Center and Darlington ...

              Days Inn by Wyndham Florence/I-95 North$64

              Days Inn by Wyndham Florence/I-95 North$64
              Country Inn & Suites by Radisson, Florence, SC

              Country Inn & Suites by Radisson, Florence, SC

              1739 Mandeville Rd, Florence
                2.5 out of 5.0
                 
                 

                Situated in Florence, this hotel is within 6 mi (10 km) of Mcleod Regional Medical Center, Florence Museum, and Magnolia Mall. Florence Civic Center and Darlington ...

                Country Inn & Suites by Radisson, Florence, SC$93

                Country Inn & Suites by Radisson, Florence, SC$93
                Best Western Inn

                Best Western Inn

                1808 W Lucas Street, Florence
                  2.5 out of 5.0
                   
                   

                  Situated in Florence, this hotel is within 6 mi (10 km) of Florence Museum, Mcleod Regional Medical Center, and Florence Civic Center. Magnolia Mall and Darlington ...

                  Best Western Inn$76

                  Best Western Inn$76
                  TownePlace Suites by Marriott Florence

                  TownePlace Suites by Marriott Florence

                  2650 Hospitality Boulevard, Florence
                    3.5 out of 5.0
                     
                     

                    Situated in Florence, this hotel is within a 15-minute walk of Florence Civic Center and Magnolia Mall. Florence Museum and The Traces Golf Club are also within ...

                    TownePlace Suites by Marriott Florence$114

                    TownePlace Suites by Marriott Florence$114
                    SpringHill Suites by Marriott Florence

                    SpringHill Suites by Marriott Florence

                    2670 Hospitality Blvd, Florence
                      3.0 out of 5.0
                       
                       

                      Situated in Florence, this hotel is within a 10-minute walk of Florence Civic Center and Magnolia Mall. Florence Museum and Mcleod Regional Medical Center are ...

                      SpringHill Suites by Marriott Florence$134

                      SpringHill Suites by Marriott Florence$134

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.