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Florence

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Florence Flights as Low as $344

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$344 Roundtrip, found 5 days ago
$344
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $344 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$424 Roundtrip, found 5 days ago
$424
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $424 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$458 Roundtrip, found 5 days ago
$458
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $458 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$490 Roundtrip, found 5 days ago
$490
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $490 found 5 days ago
American Airlines
Tue, Jun 9 - Sat, Jun 13
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$510 Roundtrip, found 3 hours ago
$510
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jun 9 from Newark Liberty Intl. Airport to Florence Regional, returning Sat, Jun 13, priced at $510 found 3 hours ago
American Airlines
Sat, Jun 6 - Thu, Jun 11
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$520 Roundtrip, found 3 hours ago
$520
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Jun 6 from Newark Liberty Intl. Airport to Florence Regional, returning Thu, Jun 11, priced at $520 found 3 hours ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$527 Roundtrip, found 5 days ago
$527
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $527 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$550 Roundtrip, found 5 days ago
$550
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $550 found 5 days ago
American Airlines
Sat, Jun 6 - Wed, Jun 10
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$552 Roundtrip, found 3 hours ago
$552
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, Jun 6 from Newark Liberty Intl. Airport to Florence Regional, returning Wed, Jun 10, priced at $552 found 3 hours ago
American Airlines
Mon, Jun 8 - Sat, Jun 13
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$610 Roundtrip, found 3 hours ago
$610
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Mon, Jun 8 from Newark Liberty Intl. Airport to Florence Regional, returning Sat, Jun 13, priced at $610 found 3 hours ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$616 Roundtrip, found 5 days ago
$616
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $616 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$616 Roundtrip, found 6 days ago
$616
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $616 found 6 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$619 Roundtrip, found 5 days ago
$619
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $619 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$645 Roundtrip, found 5 days ago
$645
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $645 found 5 days ago
American Airlines
Wed, Sep 30 - Sun, Oct 4
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$751 Roundtrip, found 5 days ago
$751
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Sep 30 from Newark Liberty Intl. Airport to Florence Regional, returning Sun, Oct 4, priced at $751 found 5 days ago
American Airlines
Tue, Jun 9 - Wed, Jun 10
EWR
Newark Liberty Intl. Airport
FLO
Florence Regional
$773 Roundtrip, found 3 hours ago
$773
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jun 9 from Newark Liberty Intl. Airport to Florence Regional, returning Wed, Jun 10, priced at $773 found 3 hours ago

Cheap Flights to Florence

Fall in love at first flight with your vacation to Florence by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DLL airport.

What is the cheapest month to fly to Florence?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence.

What airport is best to fly into Florence?

When you’re planning your trip to Florence, convenience is the name of the game. Luckily, Florence Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Florence must-do list.

How much are flights to Florence?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $344, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence?

The trick to saving a stack of cash on your flight to Florence? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $344 right now, why wait?

Florence Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$283

Last Minute Hotel Deals in Florence

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,292 reviews)
"The staff was friendly which made check in easier and check out was a smooth transaction. The room was comfy and clean. However, there are some areas of the hotel are already showing some wear already."

Reviewed on Jun 4, 2026

Get rates
Park Inn by Radisson Florence, SC
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (174 reviews)
"N/A"

Reviewed on Jun 4, 2026

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Quality Inn & Suites Florence Civic Center
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,680 reviews)
"Great staff"

Reviewed on Jun 4, 2026

Get rates
Howard Johnson by Wyndham Florence
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (140 reviews)
"Every thing good"

Reviewed on Jun 1, 2026

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Spark by Hilton Florence North I-95, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,298 reviews)
"Clean room and breakfast was great"

Reviewed on Jun 3, 2026

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Comfort Inn & Suites Florence Center Area
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
9/10 Wonderful! (1,007 reviews)
"Everything was clean, staff was friendly. A few random beggars on the street, but that’s downtown for you."

Reviewed on Jun 3, 2026

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Hyatt Place Florence Downtown
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

2.5 out of 5
3000 W Radio Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (894 reviews)
"Front desk was professional and friendly. Lounge chair in room appeared worm and dirty. All wooden surfaces in the roo9m were sticky, departure staff said it could be the wax they use... For the charge of #133.00 including tax my wife and I were disappointed in the room. Breakfast was OK, nothing ..."

Reviewed on Jun 4, 2026

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Hampton Inn & Suites Florence Center
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,589 reviews)
"Took 27 minutes to get checked in. I was the 8th person in line. Pool was closed. No hair dryer in the room, called front desk and they did not have any. Breakfast had eggs, biscuits and gravy but no meat."

Reviewed on Jun 2, 2026

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La Quinta Inn & Suites by Wyndham Florence
See all 393 properties in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.