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Featured De Soto Family Hotels

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
4800 U.S. Highway 67, De Soto, MO
Fully refundable
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
4800 U.S. Highway 67, De Soto, MO
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
Top Points of Interests in De Soto
- Hotels near Mississippi River
- Hotels near Meramec State Park
- Hotels near Meramec River
- Hotels near Bonne Terre Mine
- Hotels near Pickle Springs Natural Area
- Hotels near Hawn State Park
- Hotels near Big River
- Hotels near St. Francois State Park
- Hotels near St. Joe State Park
- Hotels near Washington State Park
- Hotels near Crown Pointe Golf Club
- Hotels near Villa Antonio Winery
Cities near De Soto
- Fenton Hotels (26.47 mi)
- Farmington Hotels (25.8 mi)
- Ozarks Hotels (126.1 mi)
- Eureka Hotels (25.38 mi)
- Ste Genevieve Hotels (29.75 mi)
- Arnold Hotels (22.42 mi)
- Festus Hotels (10.4 mi)
- Southern Illinois Hotels (95.67 mi)
- Sullivan Hotels (33.17 mi)
- Pacific Hotels (25.71 mi)
- St. Clair Hotels (26.71 mi)
- Potosi Hotels (18.89 mi)
- Union Hotels (32.61 mi)
- Bonne Terre Hotels (14.8 mi)
- Bourbon Hotels (37.42 mi)
- Waterloo Hotels (25.83 mi)
- Tesson Ferry Hotels (26.35 mi)
- Imperial Hotels (18.56 mi)
- Park Hills Hotels (19.8 mi)
- Prairie du Rocher Hotels (25.37 mi)
Car Rentals Near De Soto
- Car rentals in Fenton
- Car rentals in Farmington
- Car rentals in Ozarks
- Car rentals in Eureka
- Car rentals in Ste Genevieve
- Car rentals in Arnold
- Car rentals in Festus
- Car rentals in Southern Illinois
- Car rentals in Sullivan
- Car rentals in Pacific
- Car rentals in St. Clair
- Car rentals in Potosi
- Car rentals in Union
- Car rentals in Bonne Terre
- Car rentals in Bourbon
- Car rentals in Waterloo
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in De Soto
- Baymont Inn and Suites by Wyndham Farmington, MO
- Comfort Inn Festus - St Louis South
- Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
- Super 8 by Wyndham Bonne Terre
- Super 8 by Wyndham Farmington
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Quality Inn Farmington
- Crown Pointe Lodge, BW Signature Collection
- Hampton Inn Farmington
- Super 8 by Wyndham Potosi
- WoodSpring Suites St. Louis Arnold